Genomics

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New genetic discovery improves understanding of congenital heart disease

A new study led by the Masonic Medical Research Institute published in the journal Cells shows for the first time that a particular gene, called VGLL4, is required for embryo development but is dispensable for myocardial growth.

21 Sep 2022

Common genetic variants of APOE associated with COVID mortality

It may be the most baffling quirk of COVID: What manifests as minor, flu-like symptoms in some individuals spirals into severe disease, disability, and even death in others.

21 Sep 2022

Study finds telomeres can set damage thresholds for cancer cells above which they cannot continue to divide

A recent study hypothesized that ALT might compromise telomere integrity if not restricted appropriately.

21 Sep 2022

Evidence A.2 lineage of monkeypox is mutating

In a recent study posted to the bioRxiv* preprint server, a team of researchers from India analyzed the whole genome sequences of the monkeypox virus isolated from monkeypox patients with and without international travel histories to understand the phylogenetic relations and genomic evolution of the virus that could contribute to higher transmission rates.

21 Sep 2022

Humanized zebrafish could aid in the search for MS drugs

The zebrafish should be known to many aquarium enthusiasts mainly because of its striking pigmentation. However, the characteristic black-blue stripes, to which the animal owes its name, only form over time.

20 Sep 2022

Epigenetic treatment can promote neuronal regrowth in the spinal cord after injury

Currently, spinal cord injury does not have any effective treatments; physical rehabilitation can help patients regain some mobility, but for severe cases the outcomes are extremely limited by the failure of spinal neurons to regenerate naturally after injury.

20 Sep 2022

Study identifies genetic variation linked with posterior urethral valves in males

Genetic variation affecting developmental genes not previously linked to urethral development may contribute to a congenital condition that is the most common cause of kidney failure in young males, a study published today in eLife suggests.

20 Sep 2022

Study identifies common genetic variants associated with musical beat synchronization

The first large-scale genomic study of musicality - published on the cover of today's Nature Human Behaviour - identified 69 genetic variants associated with beat synchronization, meaning the ability to move in synchrony with the beat of music.

19 Sep 2022

Researchers use sea anemone to understand how behavior impacts body shape during early development

As humans, we know that an active lifestyle gives us some control over our form. When we hit the pavement, track our steps, and head to the gym, we can maintain muscle development and reduce body fat.

16 Sep 2022

Strains within gut microbial species codiversified with human populations, study finds

Strains within dozens of bacterial species in the gut microbiota codiversified with human populations as they spread across the globe, according to a new study. The findings underscore the importance of understanding the potential role of population-specific microbial strains in microbiome-mediated disease and microbiota-based therapeutics.

15 Sep 2022

Scientists unravel the molecular origin of rare genetic disease cystinosis

The rare genetic disease cystinosis is caused by mutations in the gene for a protein called cystinosin. A team of scientists has now solved the structure of cystinosin and determined how mutations interfere with its normal function, providing insights into the underlying mechanisms and suggesting a way to develop new treatments for the disease.

15 Sep 2022

COVID-19's future is uncertain as infections increase and tracking decreases

Researchers review how the SARS-CoV-2 genome has changed throughout the COVID-19 pandemic.

14 Sep 2022

NIH researchers identify specific network of proteins critical to restore hearing in zebrafish

National Institutes of Health researchers have discovered a specific network of proteins that is necessary to restore hearing in zebrafish through cell regeneration.

14 Sep 2022

Study explores the impact of genetic risk variants on overall disease burden and healthy life years

In a new study, researchers explored the genetic risk factors associated with various diseases to understand their impact on healthy life years.

14 Sep 2022

Brain organoids shed light into the evolution of the human brain

Animal studies on great apes have long been banned in Europe for ethical reasons. For the question pursued here, so-called organoids, i.e. three-dimensional cell structures a few millimeters in size that are grown in the laboratory, are an alternative to animal experiments.

13 Sep 2022

Scientists estimate the impact of genetic risk factors on the loss of healthy life years

Researchers have, for the first time, systematically estimated the impact of a range of different disease-associated genetic risk factors on the loss of healthy life years. Knowing the contribution of different genetic risk factors on disease burden can help prioritise and design interventions using genetic information.

12 Sep 2022

Jumping gene plays an important role in reducing depression, fear, and anxiety

First characterized in Prof. Tadashi Yamamoto's former lab in Japan in 1996, the gene Tob is well known for the role it plays in cancer. Previous research has also indicated that it has a hand in regulating the cell cycle and the body's immune response.

9 Sep 2022

UT Southwestern scientists identify genetic mutations that contribute to nonalcoholic fatty liver disease

Using a genetic screening platform developed by a UT Southwestern Nobel Laureate, scientists with the Center for the Genetics of Host Defense at UT Southwestern Medical Center have identified genetic mutations that contribute to nonalcoholic fatty liver disease (NAFLD), providing a potential future target for therapeutic interventions.

9 Sep 2022

NIH funds $3.35 million to enhance diversity in genomics training

The National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, will fund $3.35 million over five years to launch the Genome Research Experiences to Attract Talented Undergraduates into the Genomics Field to Enhance Diversity (GREAT) program.

9 Sep 2022

Single amino acid change in TKTL1 protein underlies greater neuron production in modern humans than Neandertals

Researchers from Dresden uncover a greater neuron production in the frontal lobe during brain development in modern humans than Neandertals, due to the change of a single amino acid in the protein TKTL1.

9 Sep 2022

Genomics

New genetic discovery improves understanding of congenital heart disease

Common genetic variants of APOE associated with COVID mortality

Study finds telomeres can set damage thresholds for cancer cells above which they cannot continue to divide

Evidence A.2 lineage of monkeypox is mutating

Humanized zebrafish could aid in the search for MS drugs

Epigenetic treatment can promote neuronal regrowth in the spinal cord after injury

Study identifies genetic variation linked with posterior urethral valves in males

Study identifies common genetic variants associated with musical beat synchronization

Researchers use sea anemone to understand how behavior impacts body shape during early development

Strains within gut microbial species codiversified with human populations, study finds

Scientists unravel the molecular origin of rare genetic disease cystinosis

COVID-19's future is uncertain as infections increase and tracking decreases

NIH researchers identify specific network of proteins critical to restore hearing in zebrafish

Study explores the impact of genetic risk variants on overall disease burden and healthy life years

Brain organoids shed light into the evolution of the human brain

Scientists estimate the impact of genetic risk factors on the loss of healthy life years

Jumping gene plays an important role in reducing depression, fear, and anxiety

UT Southwestern scientists identify genetic mutations that contribute to nonalcoholic fatty liver disease

NIH funds $3.35 million to enhance diversity in genomics training

Single amino acid change in TKTL1 protein underlies greater neuron production in modern humans than Neandertals

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