Genomics

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Benefits of endurance exercise in primary mitochondrial disease depend on the underlying mutation

Mitochondria serve as the main source of energy production in our cells, and endurance exercise is generally known to improve the function of mitochondria.

4 May 2022

Experts develop new method to control gene expression using electrical signals

Researchers have created an improved method for turning genes on and off using electrical signals.

4 May 2022

Study offers a path to closing the knowledge gap about differences in breast cancer genes

Too many women are getting unnecessary mastectomies and other invasive procedures because of a knowledge gap about differences in cancer genes. A new study offers a path to closing the gap.

4 May 2022

Novel genetic mapping study traces links between DNA variations and blood proteins

A new genetic mapping study led by researchers at the Johns Hopkins Bloomberg School of Public Health traces links between DNA variations and thousands of blood proteins in two large and distinct populations. The results should help researchers better understand the molecular causes of diseases and identify proteins that could be targeted to treat these diseases.

3 May 2022

New technology to make temporary genetic modifications tested in mosquitoes

Texas A&M AgriLife Research scientists have tested a technology to make temporary genetic modifications in mosquitoes. The modifications self-delete over time.

3 May 2022

New method increases efficiency of gene editing while minimizing DNA deletion sizes

Wake Forest Institute for Regenerative Medicine (WFIRM) scientists working on CRISPR/Cas9-mediated gene editing technology have developed a method to increase efficiency of editing while minimizing DNA deletion sizes, a key step toward developing gene editing therapies to treat genetic diseases.

2 May 2022

Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

Understanding the molecular mechanisms that specify and maintain the identities of more than 200 cell types of the human body is arguably one of the most fundamental problems in molecular and cellular biology, with critical implications for the treatment of human diseases. Central to the cell fate decision process are stem cells residing within each tissue of the body.

29 Apr 2022

New workflow identifies hidden genetic connections that could improve personalized medicine for IBD

All humans carry genetic variations in their DNA, called Single Nucleotide Polymorphisms (SNPs) that can underlie susceptibility to diseases such as diabetes and cancer.

28 Apr 2022

Genetic bottlenecks could impact Wyoming toads' ability to respond to new pathogens

A new study from North Carolina State University examines immune system diversity in the critically endangered Wyoming toad and finds that genetic bottlenecks could impact a species' ability to respond to new pathogens.

28 Apr 2022

Specific genes that play important role in schizophrenia identified

Schizophrenia is a serious psychiatric disorder that starts in late adolescence or early adulthood and affects around 1 in 300 people worldwide, according to the World Health Organization.

28 Apr 2022

DGP student investigates sexual dysmorphism in mice

Isabella Salamone is an eighth-year student in the Driskill Graduate Program in Life Sciences (DGP) who is studying sexual dysmorphism in mice in the laboratory of Elizabeth McNally, MD, PhD, the Elizabeth J. Ward Professor of Genetic Medicine and director of the Center for Genetic Medicine.

28 Apr 2022

Misexpression of non-cardiac genes may lead to congenital heart disease

Inside embryonic cells, specific proteins control the rate at which genetic information is transcribed from DNA to messenger RNA – a crucial regulatory step before proteins are created. Then, organs develop and hopefully function properly.

27 Apr 2022

Researchers use a systems biology approach to parse the genetic diversity of C. difficile

Researchers at University of California San Diego School of Medicine and Jacobs School of Engineering, with colleagues at Baylor College of Medicine, have used a systems biology approach to parse the genetic diversity of Clostridioides difficile, a particularly problematic pathogen in health care settings.

27 Apr 2022

Genetic cause of lupus identified

An international team of researchers has identified DNA mutations in a gene that senses viral RNA, as a cause of the autoimmune disease lupus, with the finding paving the way for the development of new treatments.

27 Apr 2022

Gut virome may warn of a serious and often fatal disease in preterm infants

Immediately after birth, human infants begin to develop a complex, interwoven fabric of microbes in their gut.

26 Apr 2022

Genetic variations in critical mitochondrial enzyme play a role in age-related mobility changes

Age-related changes in strength and mobility may depend on genetic variations in a critical mitochondrial enzyme, suggests a study published today in eLife.

26 Apr 2022

Researchers develop new platform capable of mitochondrial DNA editing

Researchers from the Center for Genome Engineering within the Institute for Basic Science developed a new gene-editing platform called transcription activator-like effector-linked deaminases, or TALED.

25 Apr 2022

DNA analysis of tumors uncovers a 'treasure trove' of clues about the causes of cancer

DNA analysis of thousands of tumors from NHS patients has found a 'treasure trove' of clues about the causes of cancer, with genetic mutations providing a personal history of the damage and repair processes each patient has been through.

21 Apr 2022

Researchers discover more needles in the haystack in the quest to unravel Alzheimer’s disease

21 million. That's the number of genetic variations in the human genome that researchers are sifting to identify patterns predisposing people to Alzheimer's disease.

20 Apr 2022

Single-cell genome sequencing provides a new way to think about Alzheimer’s disease

Alzheimer's disease is marked by a loss of functional neurons in the brain. But what causes this loss? Through single-cell genome sequencing, researchers at Boston Children's Hospital, Brigham and Women's Hospital, and the Broad Institute show that people with Alzheimer's have an abundance of newly acquired mutations in their neurons -; more than people of the same age without Alzheimer's, and enough to disable genes important to brain function.

20 Apr 2022

Genomics

Benefits of endurance exercise in primary mitochondrial disease depend on the underlying mutation

Experts develop new method to control gene expression using electrical signals

Study offers a path to closing the knowledge gap about differences in breast cancer genes

Novel genetic mapping study traces links between DNA variations and blood proteins

New technology to make temporary genetic modifications tested in mosquitoes

New method increases efficiency of gene editing while minimizing DNA deletion sizes

Study illustrates how a protein complex controls genome organization to maintain lineage fidelity

New workflow identifies hidden genetic connections that could improve personalized medicine for IBD

Genetic bottlenecks could impact Wyoming toads' ability to respond to new pathogens

Specific genes that play important role in schizophrenia identified

DGP student investigates sexual dysmorphism in mice

Misexpression of non-cardiac genes may lead to congenital heart disease

Researchers use a systems biology approach to parse the genetic diversity of C. difficile

Genetic cause of lupus identified

Gut virome may warn of a serious and often fatal disease in preterm infants

Genetic variations in critical mitochondrial enzyme play a role in age-related mobility changes

Researchers develop new platform capable of mitochondrial DNA editing

DNA analysis of tumors uncovers a 'treasure trove' of clues about the causes of cancer

Researchers discover more needles in the haystack in the quest to unravel Alzheimer’s disease

Single-cell genome sequencing provides a new way to think about Alzheimer’s disease

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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