Genomics

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Novel method for gene editing of hPSCs yields up to 84% knockout efficiency

A Penn State-led team of interdisciplinary researchers has developed techniques to improve the efficiency of CRISPR-Cas9, the genome editing technique that earned the Nobel Prize in 2020.

9 Sep 2022

New data analysis approach could help uncover the genetic basis of many diseases

In the era of Big Data, obtaining a huge amount of information is the easy part; knowing what to do with it is another story entirely.

9 Sep 2022

A single genomic change may have given modern humans an advantage over Neanderthals

A single amino acid change in the transketolase-like 1 (TKTL1) protein may have given modern humans an advantage over more ancient contemporaries like Neanderthals by enabling increased neocortical neurogenesis, researchers report.

9 Sep 2022

Comprehensive genetic architecture atlas compiled for mutant RAS genes in cancers

Researchers at the Johns Hopkins Kimmel Cancer Center, three other cancer centers and the Johns Hopkins Bloomberg School of Public Health compiled a comprehensive genetic architecture atlas for mutant RAS genes in human cancers.

8 Sep 2022

Researchers identify DNA regions associated with physical activity or leisure screen time

In a large international study, researchers at Uppsala University have identified DNA regions that are associated with physical activity or leisure screen time.

7 Sep 2022

Clock gene-dependent glutamate signaling responsible for seasonal regulation of reproduction in bean bugs

Did you know that not only does organism's body have a biological clock that can tell the time of the day, it can also tell the time of the year? Now, researchers from Japan have found that one capable little molecule may be behind the mechanism by which the biological clock keeps track of the seasons.

6 Sep 2022

Single-cell Stereo-seq reveals new insights into axolotl brain regeneration

The axolotl Ambystoma mexicanum is a popular pet due to its unique and cute appearance. Unlike other salamanders undergoing metamorphosis, axolotls (pronounced ACK-suh-LAH-tuhl) never outgrow their larval, juvenile stage, a phenomenon called neoteny.

6 Sep 2022

Researchers use 3D mapping techniques to identify multiple genes implicated in type 2 diabetes

Researchers from Children's Hospital of Philadelphia used advanced three-dimensional mapping techniques at a microscopic level to identify a multitude of genetic variants and corresponding target gene pairings in the pancreas that are implicated in type 2 diabetes.

6 Sep 2022

Novel method can be used to study the resistance profile of bacteria that cause meningitis

A study published in the journal PLOS ONE could one day help health workers determine whether bacteria of the species Streptococcus pneumoniae, which cause meningitis – an inflammation of the membranes that envelop the brain and spinal cord – are resistant to antibiotics.

6 Sep 2022

New method accurately analyzes genomics data in cancer archival biopsies

A new paper from University of Helsinki, published today on Nature Communications, suggests a method for accurately analyzing genomics data in cancer archival biopsies.

6 Sep 2022

Neonatal ketone body plays key role in primordial follicle pool formation and regulates ovarian aging

Premature ovarian aging (POA) refers to an early decline in ovarian function; it is the main cause of infertility in elder women and is characterized by a markedly reduced ovarian reservoir.

5 Sep 2022

Researchers use Viking poop to genetically map one of the oldest human parasites

Using stool samples from Viking latrines, researchers at the University of Copenhagen have genetically mapped one of the oldest human parasites – the whipworm.

5 Sep 2022

Motion of chromatin can help facilitate effective repair of DNA damage in the nucleus

A multidisciplinary team of Indiana University researchers have discovered that the motion of chromatin, the material that DNA is made of, can help facilitate effective repair of DNA damage in the human nucleus -- a finding that could lead to improved cancer diagnosis and treatment.

2 Sep 2022

Research shows how orderly regeneration is activated after injury

The phenomenon of regeneration was discovered over 200 years ago in the freshwater polyp Hydra. Until now, however, it was largely unclear how the orderly regeneration of lost tissues or organs is activated after injury.

2 Sep 2022

Study provides a comprehensive view of the genomics of all childhood ALL subtypes

Scientists have created a roadmap of the genetic mutations present in the most common childhood cancer, acute lymphoblastic leukemia (ALL).

1 Sep 2022

Integrating recent advances in multi-omics tumor profiling into precision cancer treatment

Tumors have significant differences depending on the person affected, even if they are the same cancer, such as breast cancer.

1 Sep 2022

dsDNA Quantification for NGS Quality Control

Andrew Jones discusses the importance of quality control in NGS and the effect that a poorly followed protocol can have on experimental results.

From DeNovix Inc. 1 Sep 2022

Moffitt study uses computer modeling to demonstrate the impact of skin homeostasis on driver and passenger mutations

All normal human tissues acquire mutations over time. Some of these mutations may be driver mutations that promote the development of cancer through increased proliferation and survival, while other mutations may be neutral passenger mutations that have no impact on cancer development.

30 Aug 2022

Popular genetic method is deeply flawed, study reveals

The most common analytical method within population genetics is deeply flawed, according to a new study from Lund University in Sweden.

30 Aug 2022

Genetic screening before pregnancy detects the risk in 44% of couples

Are would-be parents carrying a genetic risk of serious illnesses that they could potentially pass on to their children? In the USA, doctors recommend that couples have genetic screening before trying to conceive.

30 Aug 2022

Genomics

Novel method for gene editing of hPSCs yields up to 84% knockout efficiency

New data analysis approach could help uncover the genetic basis of many diseases

A single genomic change may have given modern humans an advantage over Neanderthals

Comprehensive genetic architecture atlas compiled for mutant RAS genes in cancers

Researchers identify DNA regions associated with physical activity or leisure screen time

Clock gene-dependent glutamate signaling responsible for seasonal regulation of reproduction in bean bugs

Single-cell Stereo-seq reveals new insights into axolotl brain regeneration

Researchers use 3D mapping techniques to identify multiple genes implicated in type 2 diabetes

Novel method can be used to study the resistance profile of bacteria that cause meningitis

New method accurately analyzes genomics data in cancer archival biopsies

Neonatal ketone body plays key role in primordial follicle pool formation and regulates ovarian aging

Researchers use Viking poop to genetically map one of the oldest human parasites

Motion of chromatin can help facilitate effective repair of DNA damage in the nucleus

Research shows how orderly regeneration is activated after injury

Study provides a comprehensive view of the genomics of all childhood ALL subtypes

Integrating recent advances in multi-omics tumor profiling into precision cancer treatment

dsDNA Quantification for NGS Quality Control

Moffitt study uses computer modeling to demonstrate the impact of skin homeostasis on driver and passenger mutations

Popular genetic method is deeply flawed, study reveals

Genetic screening before pregnancy detects the risk in 44% of couples

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