Genomics

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Novel targets for treating sorafenib-resistant hepatocellular carcinoma found using CRISPR-Cas9 screening

This study is led by Xiujun Cai (Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University School of Medicine). Professor Xiujun Cai's research team screened the whole genome of hepatocellular carcinoma cells (HepG2) through CRISPR / cas9 system under sorafenib treatment, and screened the dominant gene in sorafenib resistance.

20 Apr 2022

Small genetic differences can affect the ability to utilize energy of various nutrients, study finds

Carbohydrates, proteins and fats are essential nutrients to all animals. Yet dietary variation between species, populations and individuals can vary dramatically.

19 Apr 2022

Researchers develop and validate polygenic risk scores for six common diseases

A person's risk of developing diseases such as type 2 diabetes or breast cancer may be influenced by thousands of genetic differences.

18 Apr 2022

Research shines light on the effects of genomic variation on gut microbiome function

New research from Cornell scientists is exploring how human genetics impacts functions of the gut microbiome, and is expanding awareness of the role human genetics plays in shaping the microbiome.

18 Apr 2022

Two strains of TB bacterium attack the lungs in completely different fashion, study finds

Two strains of the bacterium causing tuberculosis have only minor genetic differences but attack the lungs in completely different fashion, according to Rutgers researchers.

18 Apr 2022

RNA interference triggers that target SARS-CoV-2 genome

Researchers screened ribonucleic acid interference against SARS-CoV-2.

18 Apr 2022

Manipulating a specific gene from yeast could lead a new approach to combatting drug resistance

A recent study that shows manipulating and deleting a specific gene (AMN1) from yeast could provide a foundation for a new approach to combatting drug resistance when treating microbial infections or cancer.

18 Apr 2022

Yale research demonstrates the cancer relevance of known human genes

Following an analysis of over 12,000 human genes, research from Yale Cancer Center indicates there is cancer-relevant importance in a much larger proportion of human genes than current cancer research models suggest.

14 Apr 2022

Bioprinting for bone repair enhanced with two growth factor encoding genes

Given enough time and energy, the body will heal, but when doctors or engineers intervene, the processes do not always proceed as planned because chemicals that control and facilitate the healing process are missing.

13 Apr 2022

Researchers construct first single-cell atlas of postnatal lung development in humans and mice

How do the lungs develop after taking their first breaths outside the womb? What cellular events and changes early in life give rise to lung malfunction and disease? To help answer these questions, scientists have constructed the first single-cell atlas of postnatal lung development in humans and mice.

12 Apr 2022

Vaccine-induced blood clots may be the result of genetics, study finds

The rare blood clot side-effect associated with some COVID-19 vaccines could be the result of genetics, new research has found, paving the way for a potential genetic screening test.

11 Apr 2022

Shared gene expression signatures in type 1 diabetics treated with IL-2 and COVID-19 patients

Researchers assess the impact of interval administration of LD-IL-2 was examined in 18 T1D patients who received a three-day dosing interval.

10 Apr 2022

MOFs could help improve the delivery of genetic cargo into target cells

Hybrid material helps ferry genetic cargo to target cells. An emerging type of material called a metal-organic framework(MOF) could help improve the delivery of genetic material for treating disease.

10 Apr 2022

UNSW research improves fundamental understanding of the mechanism behind sickle cell disease

UNSW researchers have used CRISPR gene editing – a type of 'molecular scissors' – to understand how deletions in one area of the genome can affect the expression of nearby genes.

8 Apr 2022

Large-scale study sheds more light on the genetic basis of schizophrenia

What is the role of genetics in schizophrenia? To address this question, an international group of researchers led by Charité – Universitätsmedizin Berlin and Cardiff University developed and conducted the largest-ever genetic study on schizophrenia.

7 Apr 2022

Unique immune cell fingerprint can help rapidly identify better treatment for autoimmune disease

Most autoimmune diseases are easy to diagnose but hard to treat. A paper published today in Science proposes using your unique immune cell fingerprint to rapidly identify which treatments will work for your autoimmune disease.

7 Apr 2022

Researchers develop universal AI algorithm to "clean" noisy single-cell RNA sequencing data

Just as asking a single person about their health will provide tailored, personalized information impossible to glean from a large poll, an individual cell's genome or transcriptome can provide much more information about their place in living systems than sequencing a whole batch of cells.

7 Apr 2022

Researchers discover over 40 new genetic markers for Alzheimer’s disease

A new Nature Genetics study describes over 70 gene markers that appear to be significantly associated with AD risk using translational genomics.

6 Apr 2022

Human genome sequenced in its entirety for the first time

An international team of almost one hundred scientists has uncovered the complete, gap-free human genome by deciphering the remaining and hitherto unknown sequences – opening the door for novel approaches to treat various diseases. This seminal, historical study is published in the renowned journal Science.

3 Apr 2022

TLR7 and MARK1 genomic variants impact COVID-19 prognosis

Researchers conduct a massive exome-wide genome study to explore the connections between gene variants/deleterious mutations and COVID-19 outcomes.

3 Apr 2022

Genomics

Novel targets for treating sorafenib-resistant hepatocellular carcinoma found using CRISPR-Cas9 screening

Small genetic differences can affect the ability to utilize energy of various nutrients, study finds

Researchers develop and validate polygenic risk scores for six common diseases

Research shines light on the effects of genomic variation on gut microbiome function

Two strains of TB bacterium attack the lungs in completely different fashion, study finds

RNA interference triggers that target SARS-CoV-2 genome

Manipulating a specific gene from yeast could lead a new approach to combatting drug resistance

Yale research demonstrates the cancer relevance of known human genes

Bioprinting for bone repair enhanced with two growth factor encoding genes

Researchers construct first single-cell atlas of postnatal lung development in humans and mice

Vaccine-induced blood clots may be the result of genetics, study finds

Shared gene expression signatures in type 1 diabetics treated with IL-2 and COVID-19 patients

MOFs could help improve the delivery of genetic cargo into target cells

UNSW research improves fundamental understanding of the mechanism behind sickle cell disease

Large-scale study sheds more light on the genetic basis of schizophrenia

Unique immune cell fingerprint can help rapidly identify better treatment for autoimmune disease

Researchers develop universal AI algorithm to "clean" noisy single-cell RNA sequencing data

Researchers discover over 40 new genetic markers for Alzheimer’s disease

Human genome sequenced in its entirety for the first time

TLR7 and MARK1 genomic variants impact COVID-19 prognosis

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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