Histology & Microscopy

RSS

Super-resolution imaging reveals how disease causes cells to reorder their DNA incorrectly

Imagine you're trying to do a job and all of the information you need to do it is in a few books at the library.

22 Aug 2022

UT Southwestern's cryo-EM images shed light on the mechanisms behind Wnt signaling activation

Using UT Southwestern's Cryo-Electron Microscopy Facility, researchers have captured images of an enzyme for Wnt lipidation, which is pivotal to human development and cancer and crucial for Wnt signaling activation.

16 Aug 2022

Study finds genetic alterations in healthy cells that match with the tumor cells

A new study offers the possibility of unmasking genetic mutations in an organ well before commonly-used screening techniques detect signs of cancer.

10 Aug 2022

Study demonstrates the success rate of gene analysis using cytological specimens to be extremely high

Personalized medicine for lung cancer using molecular-targeted drugs is common but there have been no prospective validation studies done on the usefulness of lung cancer gene panel testing using cytology samples.

8 Aug 2022

Sustainable Science; What does the future look like?

We speak to Ali Safavi, CEO and Founder of Grenova about sustainable science, the impact life sciences research is having on our planet, and the solutions they offer for laboratories to help reduce their plastic waste.

From Grenova 8 Aug 2022

Researchers develop new method for visualizing single cell protein secretion with stunning resolution

We have recently witnessed the stunning images of distant galaxies revealed by the James Webb telescope, which were previously visible only as blurry spots.

5 Aug 2022

Researchers unravel mechanism of action of bacterial Tc toxin in fatal attacks

A harmful and often deadly substance made by bacteria, a bacterial toxin manipulates host cell functions and disrupts vital cell processes in a living organism.

3 Aug 2022

Innovative microscopy method reveals how neurons struggle to reach their destination in Rett syndrome models

Using an innovative microscopy method, scientists at The Picower Institute for Learning and Memory at MIT observed how newborn neurons struggle to reach their proper places in advanced human brain tissue models of Rett syndrome, producing new insight into how developmental deficits observed in the brains of patients with the devastating disorder may emerge.

29 Jul 2022

Researchers report near-atomic-resolution images of nitrogenase during catalysis using cryo-EM

Previously, it has been impossible to capture the high-resolution images of nitrogenase, the only enzyme capable of reducing nitrogen into ammonia, during catalytic action.

29 Jul 2022

New ultra-thin photoacoustic endomicroscopy probe can be easily integrated with medical devices

Researchers have created a photoacoustic imaging endoscope probe that can fit inside a medical needle with an inner diameter of just 0.6 millimeters.

28 Jul 2022

Researchers develop new kind of Atomic Force Microscopy probes in true 3D shapes

A team of researchers from NYU Abu Dhabi's Advanced Microfluidics and Microdevices Laboratory (AMMLab) have developed new kind of Atomic Force Microscopy (AFM) probes in true three-dimensional shapes they call 3DTIPs. AFM technology allows scientists to observe, measure, and manipulate samples and micro and nanoscale entities with unprecedented precision.

26 Jul 2022

Genome arrangement of tree ferns offers insights into its evolution

Land plants evolved 470 million years ago from algae and have since reshaped our world. Throughout their evolution, ferns have undergone a series of changes that have helped them survive on land.

25 Jul 2022

Stopping 'budding' viruses in their tracks

Paramyxoviruses have the potential to trigger a devastating pandemic. This family of viruses includes measles, Nipah virus, mumps, Newcastle disease and canine distemper.

20 Jul 2022

Simple, effective method can detect protein misfolding at an early stage of neurodegenerative disease

Neurodegenerative diseases like Alzheimer's disease or Parkinson's disease are caused by folding errors (misfolding) in proteins or peptides, i.e. by changes in their spatial structure.

20 Jul 2022

Researchers use high-speed atomic force microscopy to explore the binding mechanism of cadherins

Cell, tissue, and organ structure is maintained by cell-cell adhesion molecules that connect opposing cells. Cadherins are a class of essential cell-cell adhesion molecules for tissue formation and integrity, and defects in cadherin function cause various diseases (e.g., cancer invasion).

19 Jul 2022

Pox viruses deliver proteins that directly interfere with the body's innate immune system

Pox viruses are able to get a head start on infecting a host by delivering a package of proteins that directly interferes with the body's innate immune system.

15 Jul 2022

Prion imaging could lead to better understanding of what causes fatal neurological disorders

Prion diseases are incurable, deadly neurological disorders that can affect both humans and animals–including Creutzfeldt-Jakob Disease (CJD) in people, Bovine Spongiform Encephalopathy (also known as Mad Cow Disease) and Chronic Wasting Disease found in deer.

13 Jul 2022

UT Southwestern researchers reveal the physical mechanism behind a neurological autoimmune disease

Using UT Southwestern's Cryo-Electron Microscopy Facility, researchers for the first time have captured images of an autoantibody bound to a nerve cell surface receptor, revealing the physical mechanism behind a neurological autoimmune disease.

11 Jul 2022

Knowledge of HIV Pol polyprotein's structure could spur the development of new therapies

In a discovery that could spur the development of new therapies for more than 40 million HIV patients worldwide, scientists from Rutgers University and the Salk Institute determined the molecular structure of the HIV Pol polyprotein, a protein that plays a critical role in helping the virus propagate itself and spread throughout the body.

7 Jul 2022

Shapeshifting behavior of E. coli may offer clues to combat urinary tract infections

Urinary tract infections are both very common and potentially very dangerous. More than half of all Australian women will suffer from a UTI in their lifetime, and nearly one in three women will have an infection requiring treatment with antibiotics before the age of 24.

28 Jun 2022