Histology & Microscopy

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Gene-silencer study could pave the way for novel cancer therapeutics

Deep inside our cells - each one complete with an identical set of genes - a molecular machine known as PRC2 plays a critical role in determining which cells become heart cells, versus brain or muscle or skin cells.

26 Sep 2023

Study discovers a new endocytic pathway in budding yeast

Endocytosis is an important cellular process through which cells internalize substances such as water and nutrients.

25 Sep 2023

New insights into the molecular mechanism of protein degradation

Within the intricate molecular landscape inside of a cell, the orchestration of proteins demands precise control to avoid disease.

22 Sep 2023

A family of weird proteins hijacks plants’ cellular plumbing

Many of the bacteria that ravage crops and threaten our food supply use a common strategy to cause disease: they inject a cocktail of harmful proteins directly into the plant's cells.

13 Sep 2023

Elevated pressure in the bile canaliculi alters structure of the liver tissue

The liver produces bile, which the intestine uses for digestion. For the transport of bile, the liver relies on a network of microscopic tubings, known as bile canaliculi, formed by liver cells called hepatocytes.

7 Sep 2023

Researchers unearth secrets of zinc transporter protein

A group of researchers has unearthed the secrets behind a tiny but crucial protein that shuttles zinc ions (Zn2+) within our bodies. The discovery offers a deeper understanding of how our cells maintain optimal health.

31 Aug 2023

Ion channel proteins can transiently rearrange into larger structures

A member of an important class of ion channel proteins can transiently rearrange itself into a larger structure with dramatically altered properties, according to a study led by researchers at Weill Cornell Medicine.

30 Aug 2023

Researchers discover how proteins regulate 'treadmilling' in cells

Researchers at the Centre for Genomic Regulation (CRG) have discovered how proteins work in tandem to regulate 'treadmilling', a mechanism used by the network of microtubules inside cells to ensure proper cell division.

25 Aug 2023

New approach reveals spongelike properties of the skin’s dermis layer

Hydraulic permeability - the ability of water to move in all directions through a multicellular complex tissue - allows skin to maintain turgor and appear plump.

22 Aug 2023

The ancestral origins of the cardiovascular system

Coronary arteries are a vital part of the human heart, providing it with oxygen-rich blood so that it can work.

22 Aug 2023

Researchers decipher the mode of action of new antibiotic

More and more bacterial pathogens are developing resistance. There is an increasing risk that common drugs will no longer be effective against infectious diseases.

22 Aug 2023

Scientists map how worm brain encodes behavior

To understand the full relationship between brain activity and behavior, scientists have needed a way to map this relationship for all of the neurons across a whole brain - a so far insurmountable challenge.

21 Aug 2023

Scientists capture first images of ribosome-modifying enzymes in action

Bacteria draw from an arsenal of weapons to combat the drugs intended to kill them. Among the most prevalent of these weapons are ribosome-modifying enzymes.

14 Aug 2023

Cryo-EM structures and functions of potent bispecific antibodies against multiple Omicron sublineages

Researchers characterizes the structures and functions of potent bispecific antibodies against multiple Omicron subvariants using Cryo-EM.

3 Aug 2023

New technique revolutionizes protein-ligand interaction studies

Raman spectroscopy - a chemical analysis method that shines monochromatic light onto a sample and records the scattered light that emerges - has caused frustration among biomedical researchers for more than half a century.

28 Jul 2023

Cryo-EM study elucidates 3D structure and molecular mechanism of platelet drug transporter

A research team led by Prof. CHEN Yuxing and Prof. ZHOU Cong from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences (CAS) recently utilized single-particle cryogenic electron microscopy (cryo-EM) to decipher the 3D structure and molecular mechanism of the platelet drug transporter ABCC4.

28 Jul 2023

New nano-immune magnetic bead developed for efficient SARS-CoV-2 virus detection

A more efficient way to test SARS-CoV-2 Virus was developed recently by a research team led by Professor WANG Junfeng from Hefei Institutes of Physical Science (HFIPS), Chinese Academy of Science (CAS).

28 Jul 2023

Scientists map 3D structure of kappa opioid receptor

Opioids remain the most potent and effective pain relievers in medicine, but they're also among the most addictive drugs that can halt a person's ability to breathe during an overdose - which can be deadly.

27 Jul 2023

Scientists unravel step-by-step activation process of protein with deep evolutionary history

Scientists have unraveled the step-by-step activation process of a protein with a deep evolutionary history in all domains of life, opening the door to harnessing its functions for use as a biotechnology tool.

26 Jul 2023

Scientists discover new details about RNA editing in single-celled, disease-causing parasite

As molecular biologists at Boston University and as husband and wife, Ruslan Afasizhev and Inna Afasizheva, have worked together for decades. Together, they have published dozens of papers on the mechanics of mitochondrial DNA and RNA in a single-celled, disease-causing parasite called Trypanosoma brucei.

19 Jul 2023