Histology & Microscopy

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Study uncovers novel mechanisms underlying plant immunity against major root disease

Researchers led by CHEN Yuhang and ZHOU Jianmin from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences have shown how plants resist clubroot, a major root disease that threatens the productivity of Brassica crops such as rape.

8 Jun 2023

Teaming up with the patient’s immune system to combat cancer

The fact that our immune systems capture and destroy nanoparticles and the drugs they carry has been a problem in the field of nanomedicine for some time. But, in the fight against cancer, researchers are now attempting to exploit this problem to their advantage.

8 Jun 2023

New process can help to design drugs with fewer or no side effects

Have you ever wondered how drugs reach their targets and achieve their function within our bodies? If a drug molecule or a ligand is a message, an inbox is typically a receptor in the cell membrane.

7 Jun 2023

Innovative platform helps observe the fine details of luminal flow around the villi

Science is well aware of the important role that gut bacteria and their interactions with the gastrointestinal tract play in our overall health.

30 May 2023

New method to study the ultra-fast movements of proteins

Proteins are biological molecules that perform almost all biochemical tasks in all forms of life. In doing so, the tiny structures perform ultra-fast movements.

30 May 2023

Defective proteins involved in ER-phagy can cause neurodegenerative diseases

Our cells are crisscrossed by a system of membrane tubes and pockets called the endoplasmic reticulum (ER). It is crucial for the production of biomolecules and is continuously built up and degraded.

26 May 2023

Fast and accurate automatic neuron reconstruction using 3D images

Dr. Shuiwang Ji, a professor in the Department of Computer Science and Engineering at Texas A&M University, is part of a collaborative research community that recently had its paper titled "BigNeuron: a resource to benchmark and predict performance of algorithms for automated tracing of neurons in light microscopy datasets" published in the April issue of the journal Nature Methods.

26 May 2023

Bridging the Gap between Academia and Industry: The Power of Collaboration in Life Sciences

In this behind-the-scenes interview, we speak to Dr. Sinead Knight, chair of SLAS Europe 2023, about this years programme, highlighting the key topics and speakers.

From Society for Laboratory Automation and Screening (SLAS) 25 May 2023

$Using 3D-electron diffraction to determine the structure of Levocetirizine dihydrochloride$

Using 3D-electron diffraction to determine the structure of Levocetirizine dihydrochloride

For pharmaceuticals, knowing the chemical composition is not enough - molecular geometry and crystal structure also play an important role in a drug's activity.

23 May 2023

Understanding the cause for suboptimal germinal center response in aged mice

Understanding the ways our immune response changes as we age holds the key to designing better vaccines and boosting protection for people most at risk.

22 May 2023

Novel tool paves the way for automated identification and localization of proteins in cells

Electron cryo-tomography (cryo-ET) is emerging as a powerful technique to provide detailed 3D images of cellular environments and enclosed biomolecules.

15 May 2023

Researchers create a 3D model to better understand bacteria movement

The spiral-shaped bacteria Helicobacter pylori are common and troublesome.

12 May 2023

AI used to build a 3D model of the Commander complex

University of Queensland researchers have used artificial intelligence to build a 3D map of key cell components to better understand dementia and infectious diseases including COVID-19.

11 May 2023

New advanced AI system shows accuracy and speed in identifying protein patterns

A new advanced artificial intelligence (AI) system has shown world-leading accuracy and speed in identifying protein patterns within individual cells.

10 May 2023

New drug delivery system delivers antioxidant directly to mitochondria in the liver

A new drug delivery system delivers an antioxidant directly to mitochondria in the liver, mitigating the effects of oxidative stress.

10 May 2023

Ultra-long protein fibrils are a signature of severe Alzheimer’s disease, study shows

During the course of Alzheimer's disease, protein fibrils appear in the spinal fluid of affected individuals. Empa researchers, together with the Department of Neurology at the Cantonal Hospital in St. Gallen, have now visualized the wide spectrum of protein aggregates from oligomers, protofibrils to fibrils in the spinal fluid.

9 May 2023

High-resolution atlas illustrates the development of human retina

What cell types are found in which human tissue, and where? Which genes are active in the individual cells, and which proteins are found there?

8 May 2023

Powerful two-photon microscopy for imaging fast biological processes

Two-photon microscopy (TPM) has revolutionized the field of biology by enabling researchers to observe complex biological processes in living tissues at high resolution.

4 May 2023

Researchers develop a deep learning model to classify cancer cells by type

Cancer cells that initiate metastasis, or the spread of the disease from its primary location, are different from cancer cells that stay in the original tumor. Distinguishing metastasis-initiating cell types can determine the severity of cancer and help medical practitioners decide on a course of treatment.

2 May 2023

African psychedelic plant medicine inspires new drug candidates for treating addiction and depression

Scientists have developed two new drug candidates for potentially treating addiction and depression, modeled on the pharmacology of a traditional African psychedelic plant medicine called ibogaine.