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Scientists find how APOBEC protein becomes dangerous when DNA replication process goes wrong

Cancer is caused by the growth of an abnormal cell which harbours DNA mutations, "copy errors" occurring during the DNA replication process. If these errors do take place quite regularly without having any damaging effect on the organism, some of them affect a specific part of the genome and cause the proliferation of the mutant cell, which then invades the organism.

25 Jan 2016

African-American pediatric lymphoma patients have inferior outcomes compared to white and Hispanic peers

Researchers from Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine today published a study showing that African-American pediatric Hodgkin lymphoma patients have inferior overall survival to their white and Hispanic peers.

25 Jan 2016

Chronic exposure to environmental toxin may up risk of neurodegenerative illness

A new study published today in the science journal Proceedings of the Royal Society B indicates that chronic exposure to an environmental toxin may increase risk of neurodegenerative illness. Conducted by scientists at the Institute for EthnoMedicine, a non-profit medical research organization, and the University of Miami Brain Endowment Bank, the study provides a foundation for future research in Alzheimer's disease, ALS and Parkinson's disease.

25 Jan 2016

Neurocutaneous disorders affect skin, nervous system

One of the most common genetic disorders is a condition called neurofibromatosis, which causes brown spots on the skin and benign tumors on the brain, spinal cord and other parts of the nervous system.

25 Jan 2016

CNIC researchers identify how two proteins control heart growth and adaptation to hypertension

Researchers at the Centro Nacional de Investigaciones Cardiovasculares Carlos III have identified how two proteins control the growth of the heart and its adaptation to high blood pressure (hypertension).

25 Jan 2016

Vascular risk factors implicated in normal pressure hydrocephalus

Researchers have found that vascular risk factors are associated with idiopathic normal pressure hydrocephalus and could be a possible target for intervention.

22 Jan 2016

$Parathyroid hormone may mediate antihypertensive fracture risk$

Parathyroid hormone may mediate antihypertensive fracture risk

Parathyroid hormone levels may be elevated by use of some antihypertensive agents but reduced by others, analysis of the Multi-Ethnic Study of Atherosclerosis suggests.

22 Jan 2016

Positive bosutinib response for elderly blast phase CML patient

A case study suggests that the third-generation tyrosine kinase inhibitor bosutinib may be considered as induction therapy for blast phase chronic myeloid leukaemia in older patients.

22 Jan 2016

Cardiovascular considerations crucial for CML TKI patients

A review of BCR–ABL1 tyrosine kinase inhibitors highlights the need to consider cardiovascular adverse event risk profiles when prescribing for patients with chronic myeloid leukaemia.

22 Jan 2016

Sunitinib versus everolimus trial highlights non-clear cell RCC patient response heterogeneity

Sunitinib offers significantly longer progression-free survival than everolimus for patients with metastatic non-clear cell renal cell carcinoma, phase II trial results indicate, but treatment effect appears to depend upon key patient characteristics.

22 Jan 2016

Physiotherapy ‘should be targeted’ in Parkinson’s disease

Physical and occupational therapy does not deliver quality of life benefits for patients with mild to moderate Parkinson’s disease, a randomised trial shows.

22 Jan 2016

Adjuvant Chemotherapy Colon Cancer Trials Should ‘Stratify By MSI, KRAS, BRAF’

A post hoc analysis of the PETACC-8 trial has revealed an interaction between microsatellite instability and BRAF and KRAS mutation status when determining the prognosis of patients with resected stage III colon adenocarcinoma.

22 Jan 2016

BCR–ABL transcript type linked to TKI response, outcomes

The type of BCR–ABL transcript could have an impact on tyrosine kinase inhibitor choice in patients with chronic myeloid leukaemia , according to research published in Blood.

22 Jan 2016

Audiologists investigating impact of remote care on cochlear implant users

Audiologists from the University of Southampton are investigating how a new patient-centred approach can help cochlear implant users manage their own care programme.

22 Jan 2016

UAB study shows IL-37 protein suppresses inflammatory response after spinal cord injury

Spinal cord injuries cause severe functional disabilities in those who sustain them, including paraplegia or tetraplegia, depending on the scale of the injury. This is due to the degeneration of the spinal pathways that carry nerve signals from the brain to the different parts of the body and vice versa, resulting in loss of mobility and sensitivity underneath the injured area.

22 Jan 2016

Oestrogen supplements could reduce dementia risk in women

Women who take oestrogen supplements from before or at the start of menopause and continue with them for a few years have better preserved brain structure, which may reduce the risk of dementia.

22 Jan 2016

Biomedical innovation in the UK: an interview with Zahid Latif

The biomedical research base is one of the UK's strengths; over 1500 companies in the Pharmaceuticals and biotechnology area are established in the UK employing over 70,000.

22 Jan 2016

Levels of mitochondrial DNA in the blood may predict chronic kidney disease risk

The health of blood cells' energy-producing mitochondria may predict a person's risk of developing chronic kidney disease (CKD), according to a study appearing in an upcoming issue of the Journal of the American Society of Nephrology.

22 Jan 2016

PGD model could provide policy guideposts for human genome editing

Human genome editing for both research and therapy is progressing, raising ethical questions among scientists around the world.

22 Jan 2016

Sensitive computational method could help reveal effect of the immune system on cancer

A study by researchers at Norris Cotton Cancer Center has shown that a very sensitive computational method can be used to reveal the human immune system's effect on cancer. The Dartmouth study was the first to perform an in-depth computational examination of how immune activity translates to prognosis in breast cancer.

22 Jan 2016

Medical Research News

Scientists find how APOBEC protein becomes dangerous when DNA replication process goes wrong

African-American pediatric lymphoma patients have inferior outcomes compared to white and Hispanic peers

Chronic exposure to environmental toxin may up risk of neurodegenerative illness

Neurocutaneous disorders affect skin, nervous system

CNIC researchers identify how two proteins control heart growth and adaptation to hypertension

Vascular risk factors implicated in normal pressure hydrocephalus

Parathyroid hormone may mediate antihypertensive fracture risk

Positive bosutinib response for elderly blast phase CML patient

Cardiovascular considerations crucial for CML TKI patients

Sunitinib versus everolimus trial highlights non-clear cell RCC patient response heterogeneity

Physiotherapy ‘should be targeted’ in Parkinson’s disease

Adjuvant Chemotherapy Colon Cancer Trials Should ‘Stratify By MSI, KRAS, BRAF’

BCR–ABL transcript type linked to TKI response, outcomes

Audiologists investigating impact of remote care on cochlear implant users

UAB study shows IL-37 protein suppresses inflammatory response after spinal cord injury

Oestrogen supplements could reduce dementia risk in women

Biomedical innovation in the UK: an interview with Zahid Latif

Levels of mitochondrial DNA in the blood may predict chronic kidney disease risk

PGD model could provide policy guideposts for human genome editing

Sensitive computational method could help reveal effect of the immune system on cancer

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