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Gene transfer technology may lead to an HIV vaccine

A research team may have broken the stubborn impasse that has frustrated the invention of an effective HIV vaccine, by using an approach that bypasses the usual path followed by vaccine developers.

17 May 2009

Genetic basis for environmental and occupational respiratory diseases

Exposure to particulate matter has been recognized as a contributing factor to lung cancer development for some time, but a new study indicates inhalation of certain particulates can actually cause some genes to become reprogrammed, affecting both the development and the outcome of cancers and other diseases.

17 May 2009

Could sleep be a critical component to maintaining a healthy body weight?

Could sleep be a critical component to maintaining a healthy body weight? According to new research to be presented on Sunday, May 17, at the American Thoracic Society's 105th International Conference in San Diego, body mass index (BMI) is linked to length and quality of sleep in a surprisingly consistent fashion.

17 May 2009

Transplant patients experience worse outcomes from cancer

After comparing two patient cancer registries - one featuring transplant patients and the other the general population - researchers at the University of Cincinnati (UC) have found that transplant patients experience worse outcomes from cancer.

17 May 2009

Pazopanib shows promise for aggressive thyroid cancer

A medication that helps stop the growth of new blood vessels has produced dramatic benefits for some patients with aggressive thyroid cancer, research from Mayo Clinic indicates.

17 May 2009

Biological timekeeper studies reveal new temperature regulator and track clock protein across a day

Dartmouth Medical School geneticists have made new inroads into understanding the regulatory circuitry of the biological clock that synchronizes the ebb and flow of daily activities, according to two studies published May 15.

17 May 2009

Amino acid glutamine show promise in treating stomach ulcers

Nearly 20 years ago, it was discovered that bacteria known as Helicobacter pylori were responsible for stomach ulcers. Since then, antibiotics have become the primary therapy used to combat the H. pylori infection, which affects approximately six percent of the world population and is also a primary cause of stomach cancer. But today the bacteria is growing increasingly resistant to antibiotics.

17 May 2009

A link found between atrial fibrillation and Alzheimer's disease

Researchers at Intermountain Medical Center in Salt Lake City believe that they have made a breakthrough connection between atrial fibrillation, a fairly common heart rhythm disorder, and Alzheimer's disease, the leading form of dementia among Americans.

17 May 2009

Study compares aspirin types

For many years, it has been known that aspirin is beneficial to patients suffering heart attacks and near-heart attacks. But which of the many different types of aspirin is likely to help the most?

17 May 2009

New system to deliver siRNA into primary cells

In technology that promises to one day allow drug delivery to be tailored to an individual patient and a particular cancer tumor, researchers at the University of California, San Diego School of Medicine, have developed an efficient system for delivering siRNA into primary cells.

17 May 2009

Genetic signature may predict patient response to GIST therapy

Researchers at Fox Chase Cancer Center uncovered a genetic pattern that may help predict how gastrointestinal stromal tumor (GIST) patients respond to the targeted therapy imatinib mesylate (Gleevec). Moreover, their findings point to genes that could be suppressed in order to make these tumors respond more readily to imatinib.

15 May 2009

Researchers unravel key mechanism in pathogenesis of osteoporosis

Osteoporosis, or bone loss, is a disease that is most common in the elderly population, affecting women more often than men. Until now, it was not clear exactly how the disease develops.

15 May 2009

A relationship found between cancer stem cells and prognosis in primary breast cancer

Breast cancer patients who received chemotherapy prior to surgery had heightened levels of cancer-initiating stem cells in their bone marrow, and the level of such cells correlated to a tumor's lymph node involvement, according to research from The University of Texas M. D. Anderson Cancer Center.

15 May 2009

Chronic infection clearly linked to key immunity protein

The reason deadly infections like human immunodeficiency virus (HIV) and hepatitis C never go away is because these viruses disarm the body's defense system.

15 May 2009

Determining success or failure in cholesterol-controlling drugs

Researchers at the University of California, San Diego have discovered that a complex network of interactions between drugs and the proteins with which they bind can explain adverse drug effects. Their findings suggest that adverse drug effects might be minimized by using single or multiple drug therapies in order to fine-tune multiple off-target interactions.

15 May 2009

Ginger reduces post-chemotherapy nausea

People with cancer can reduce post-chemotherapy nausea by 40 percent by using ginger supplements, along with standard anti-vomiting drugs, before undergoing treatment, according to scientists at the University of Rochester Medical Center.

15 May 2009

New therapy improves chances of living disease-free with neuroblastoma

A phase III study has shown that adding an antibody-based therapy that harnesses the body's immune system resulted in a 20 percent increase in the number of children living disease-free for at least two years with neuroblastoma.

15 May 2009

Cytomegalovirus may cause high blood pressure

A new study suggests for the first time that cytomegalovirus (CMV), a common viral infection affecting between 60 and 99 percent of adults worldwide, is a cause of high blood pressure, a leading risk factor for heart disease, stroke and kidney disease.

15 May 2009

The end of the line for existing stem cell research?

Time is short for scientists to respond to the call for comments on the National Institutes of Health (NIH) proposed guidelines for the use of human embryonic stem (ES) cell lines and their eligibility for federal funds. On May 26, the window to provide feedback will close, and the drafted rules leave the possibility that funding for almost all existing cell lines will disappear.

15 May 2009

Old diabetes drug Metformin teaches experts new tricks

Research from the Johns Hopkins Children's Center reveals that the drug most commonly used in type 2 diabetics who don't need insulin works on a much more basic level than once thought, treating persistently elevated blood sugar - the hallmark of type 2 diabetes - by regulating the genes that control its production.

15 May 2009