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CCTP focuses on identifying, testing drugs for cancer stem cell treatment

Cancer and stem cell biology researchers at the University of Colorado are launching the nation's first program focused on identifying and testing drugs that target and destroy cells thought to be at the root of cancer-cancer stem cells (CSCs).The Cancer Stem Cell-Directed Clinical Trials Program (CCTP) is a collaboration between the University of Colorado Cancer Center and the Charles C. Gates Center for Regenerative Medicine and Stem Cell Biology, both located at the University of Colorado School of Medicine.

17 Jul 2010

AMPK may regulate epigenetic mechanism: Research

AMP-activated protein kinase, or AMPK, is a master regulator protein of metabolism that is conserved from yeast to humans. When a cell is low on fuel, AMPK shuts down processes that use energy and turns on processes that produce energy.Biologists have been studying how AMPK works for several decades and know that once it is activated, AMPK turns on a large number of genes by passing the "make more energy" message through numerous signaling cascades in the cell. What was not known, until now, was that AMPK also works via an epigenetic mechanism to slow down or stop cell growth.

17 Jul 2010

InformedDNA named finalist for Best Practices in Health Care Consumer Empowerment and Protection Awards

Informed Medical Decisions, Inc. (InformedDNA) has been selected as one of 30 finalists for the Best Practices in Health Care Consumer Empowerment and Protection Awards. URAC, the nation's leading accreditation organization, will honor the finalists during their 11th Annual Quality Summit, October 5-7, 2010 in Chicago, IL.

17 Jul 2010

Proton therapy treatment for anal canal cancer performed for first time in US

The INTEGRIS Cancer Institute of Oklahoma and the ProCure Proton Therapy Center announce a breakthrough treatment approach for anal canal cancer. For the first time in the United States proton therapy is now being used to treat this type of cancer.

17 Jul 2010

Florida Institute of Technology assists licensing CDNI-Glu compound to UK company

As a national research university, Florida Institute of Technology not only involves its students in research, but also seeks to license and patent its many innovations. An example of recently licensed university technology is a chemical compound that facilitates the work of neuroscientists in the laboratory.Associate Professor Nasri Nesnas was familiar as a chemist with the chemical compound CDNI-Glu, a commonly used laboratory research tool. Most often, neuroscientists use it to study the brain's neural networks by improving the localization of synaptic stimulation

17 Jul 2010

Resveratrol concentration impacts cancer risk mitigation: Study

Agricultural Research Service (ARS) chemist Thomas Wang, who specializes in cancer prevention research, has reported evidence that for some dietary compounds, length of exposure over time may be key to whether or not ingestion leads to a beneficial, or detrimental, effect.Scientists do not know exactly why one person develops cancer and another does not. But they do know that certain nutrients might increase or decrease cancer risk. There are "layers" of factors involved in the development of cancer, and Wang is studying the layers involving peoples' diet complexity and gene expression.

17 Jul 2010

Cage type affects laboratory mice brain

Researchers at the University of Colorado's Anschutz Medical Campus have found the brains of mice used in laboratories worldwide can be profoundly affected by the type of cage they are kept in, a breakthrough that may require scientists to reevaluate the way they conduct future experiments.

17 Jul 2010

Epizyme publishes two new review papers on epigenetics

Epizyme, Inc., a company leading the discovery and development of first-in-class, targeted cancer therapeutics against epigenetic targets, announced today the publication of two new review papers in the area of epigenetics. Together, the articles provide an overview of the major epigenetic enzyme classes, as well as chemical biology approaches for discovering small molecule inhibitors of these epigenetic enzymes, and demonstrate Epizyme's scientific leadership in the area of epigenetics.

17 Jul 2010

ArmaGen uses BBB molecular Trojan horse platform technology to create brain penetrating form of human EPO

Human erythropoietin (EPO) is a potent neuroprotective agent for multiple brain disorders, including stroke, brain and spinal cord injury, and Parkinson's disease. However, EPO drug development for the brain is limited, because EPO does not cross the blood-brain barrier (BBB). In acute stroke or brain injury, the BBB is intact in the early hours after the insult when neuroprotection is still possible. Therefore, large molecule biopharmaceuticals such as EPO must be re-engineered to enable BBB transport.

17 Jul 2010

Researchers discover potential way to stop tumor growth

Washington State University researchers have discovered a way to help cancer cells age and die, creating a promising avenue for slowing and even stopping the growth of tumors. "Hopefully, we can make cancer cells die like normal cells," says Weihang Chai, an assistant professor in the WSU School of Molecular Biosciences and WWAMI medical education program in Spokane. "Basically, you make the cancer cell go from immortal to mortal."

17 Jul 2010

FDA can promote personalized medicine by identying gaps in laboratory operations: ACLA

The Food and Drug Administration can promote progress toward personalized medicine by approaching the oversight of laboratory developed tests (LDTs) in a focused, flexible, and balanced way according to the American Clinical Laboratory Association (ACLA). ACLA, which represents the nation's leading clinical laboratories, says that the factors supporting this approach include the growing role that such tests play in clinical decision making, especially in the area of new advanced diagnostics that derive from the mapping of the human genome and help fulfill the promise of personalized medicine.

17 Jul 2010

Opinions: Science communication for development; International disaster response

"Helping developing countries communicate and use science is essential to international aid and diplomacy. The biggest single factor limiting developing countries' potential for achieving sustainable economic growth - or even attaining the Millennium Development Goals - is their ability to access and apply the fruits of modern science and technology," David Dickson, the director of SciDev.Net, writes in an editorial on the website.

17 Jul 2010

Research findings may help identify human TOR kinase inhibitors

A parasite estimated to afflict as many as 12 million people worldwide relies on a family of genes that should make it vulnerable to compounds developed to treat cancer and other disorders, researchers at Washington University School of Medicine in St. Louis have found.

17 Jul 2010

Largest effort to find gene-environment interactions underlying schizophrenia risk

At the 23rd ECNP Congress 2010 in Amsterdam, Professor Dr. Jim van Os, Chairman of the Department of Psychiatry and Neuropsychology at Maastricht University Medical Centre, The Netherlands, will present the EU-GEI project, involving more than 7,500 patients and their families, which brings together a multidisciplinary research team from 15 countries in the largest effort to date to find gene-environment interactions underlying schizophrenia risk.

16 Jul 2010

Lab-on-Bead technology helps researchers cut years from drug development

New research accepted by the Journal of Molecular Recognition confirms that a revolutionary technology developed at Wake Forest University will slash years off the time it takes to develop drugs - bringing vital new treatments to patients much more quickly.

16 Jul 2010

Human impact on health of soil, and impact of unhealthy soil on society are intertwined, says LSU researcher

It may sound counterintuitive, but LSU Associate Professor of Chemistry Robert Cook has made a career out of studying the ways organic materials found in the environment, including soils, can either get dirty or stay clean. In fact, the National Science Foundation, or NSF, was so impressed with his efforts that the funding institute awarded Cook one of its most prestigious awards - the NSF CAREER award.

16 Jul 2010

Study finds unhappy families unhappy in two distinct ways

Contrary to Leo Tolstoy's famous observation that "happy families are all alike; every unhappy family is unhappy in its own way," a new psychology study confirms that unhappy families, in fact, are unhappy in two distinct ways. And these dual patterns of unhealthy family relationships lead to a host of specific difficulties for children during their early school years.

16 Jul 2010

Study on how cellular defence systems keep themselves in check from damaging cells themselves

When cells are attacked by bacteria they use all means at their disposal to defend themselves. But cellular defence systems can damage the cells themselves and so need to be kept tightly in check. Recent results help us to understand how this is done and give pointers to new ways of combating disease. Matthias Farlik in the group of Thomas Decker at the Centre for Molecular Biology of the University of Vienna (Max F. Perutz Laboratories) and Mathias Müller of the University of Veterinary Medicine, Vienna have published these findings in the current issue of the journal "Immunity".

16 Jul 2010

Study compares denture stomatitis genes with whole transcriptome for salivary biomarker analysis

The goal of the study was to compare whole-transcriptome, mucosal gene expression in Candida albicans (a parasitic fungus that can infect the mouth) associated chronic denture stomatitis to that of healthy oral mucosa and perform proteomic analyses of potential salivary biomarkers. Denture stomatitis is a condition in which the mucosa underneath a denture becomes inflamed and sometimes painful.

16 Jul 2010

Severe exposure to trauma, loss of family members, and domestic violence very stressful on Sri Lankan children

Two studies on children in Sri Lanka who survived the 2004 tsunami and ongoing civil war there found that it's not these stressful events alone that contributed to the youths' psychological health, but also daily stressors like domestic violence that are exacerbated by traumatic events and continue after the disasters.

16 Jul 2010

Medical Science News

CCTP focuses on identifying, testing drugs for cancer stem cell treatment

AMPK may regulate epigenetic mechanism: Research

InformedDNA named finalist for Best Practices in Health Care Consumer Empowerment and Protection Awards

Proton therapy treatment for anal canal cancer performed for first time in US

Florida Institute of Technology assists licensing CDNI-Glu compound to UK company

Resveratrol concentration impacts cancer risk mitigation: Study

Cage type affects laboratory mice brain

Epizyme publishes two new review papers on epigenetics

ArmaGen uses BBB molecular Trojan horse platform technology to create brain penetrating form of human EPO

Researchers discover potential way to stop tumor growth

FDA can promote personalized medicine by identying gaps in laboratory operations: ACLA

Opinions: Science communication for development; International disaster response

Research findings may help identify human TOR kinase inhibitors

Largest effort to find gene-environment interactions underlying schizophrenia risk

Lab-on-Bead technology helps researchers cut years from drug development

Human impact on health of soil, and impact of unhealthy soil on society are intertwined, says LSU researcher

Study finds unhappy families unhappy in two distinct ways

Study on how cellular defence systems keep themselves in check from damaging cells themselves

Study compares denture stomatitis genes with whole transcriptome for salivary biomarker analysis

Severe exposure to trauma, loss of family members, and domestic violence very stressful on Sri Lankan children

How can microdialysis benefit drug development

Global and Local Efforts to Take Action Against Hepatitis

Addressing Important Cardiac Biology Questions with Shotgun Top-Down Proteomics

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