Molecular & Structural Biology

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Study reveals a previously unknown mechanism for DNA folding

A hitherto unknown mechanism for DNA folding is described in a study in Nature published by researchers from Karolinska Institutet and the Max Planck Institute for Biophysics.

19 Apr 2023

New drug could effectively disarm multidrug-resistant bacteria

A new type of drug could provide a way to treat multidrug-resistant bacteria, according to a study published in Nature Communications.

19 Apr 2023

Study reveals DCAF1 protein's role in colon cancer development through EZH2 phosphorylation

A recent study reveals that DCAF1 is overexpressed and phosphorylates EZH2 in colon cancer cells.

18 Apr 2023

U-M researcher launches new project to identify the full range of RNA building blocks inside human cells

University of Michigan pediatric neurologist Vivian Cheung is launching an international project to identify the full range of RNA building blocks inside human cells.

18 Apr 2023

Researchers discover the molecule responsible for guiding T cells toward tumors

Immunotherapy, particularly CAR T-Cell treatment for cancer, is extending the lives of many patients. But sometimes the therapy randomly migrates to places it shouldn't go, tucking into the lungs or other noncancerous tissue and causing toxic side effects.

18 Apr 2023

Scientists discover a protein domain that could lead to new COVID-19 treatments

Oak Ridge National Laboratory scientists exploring bioenergy plant genetics have made a surprising discovery: a protein domain that could lead to new COVID-19 treatments.

18 Apr 2023

Study shows how a biological clock molecule contributes to lung scarring

Abnormal sleep patterns, like those of night-shift workers, disrupt the body's natural biological clock and have been linked to lung health issues.

17 Apr 2023

Study reveals molecular mechanisms that give bacteria its 'superpowers' against antibiotics

A species of ordinary gut bacteria that we all carry flourishes when the intestinal flora is knocked out by a course of antibiotics. Since the bacteria is naturally resistant to many antibiotics, it causes problems, particularly in healthcare settings.

17 Apr 2023

Study offers novel insights into reducing adverse effects of antibiotics on the gut microbiome

Antibiotics help to fight bacterial infections, but they can also harm the helpful microbes living in the gut, which can have long-lasting health consequences.

17 Apr 2023

How SARS-CoV-2 Omicron subvariants have evolved to evade host T-cell immunity

Researchers investigate whether SARS-CoV-2 and its variants have evolved to evade CD8+ T cell-mediated immunity.

15 Apr 2023

Study uncovers a novel fold within the SARS-CoV-2 replication co-factor non-structural protein 9

Researchers present the crystal structure of an anti-non-structural protein 9 specific nanobody in complex with the SARS-CoV-2 nsp9.

15 Apr 2023

Study uncovers hallmarks to improving pancreatic cancer therapy

Scientists from the University of California, Irvine, the University of Michigan and the University of Texas MD Anderson Cancer Center have made a significant contribution to the field of pancreatic cancer research.

13 Apr 2023

Genomic study reveals Babesia duncani's pathogenicity and virulence

'Tis the season for hiking now that spring has arrived and temperatures are on the upswing. But with hikes come insect bites and on the increase in North America is babesiosis, a malaria-like disease spread especially between May and October by a tick.

13 Apr 2023

Research reveals molecular features of rare mtDNA mutations

A high-throughput single-cell single-mitochondrial genome sequencing technology known as iMiGseq has provided new insights into mutations of mitochondrial DNA (mtDNA) and offers a platform for assessing mtDNA editing strategies and genetic diagnosis of embryos prior to their implantation.

13 Apr 2023

From Sanger Sequencing to the Human Genome Project: The Evolution of DNA Sequencing Technology

In this inspiring interview, we speak to Dr. Radoje Drmanac, co-founder of Complete Genomics, about the past, present, and future of genomics research.

From MGI 13 Apr 2023

The virological characteristics of XBB.1.16

Researchers perform extensive multiscale investigations to explore virological characteristics of the SARS-CoV-2 Omicron XBB subvariant, XBB.1.16.

12 Apr 2023

Salk study opens an entirely new way of thinking about cognitive decline

Brains are like puzzles, requiring many nested and codependent pieces to function well. The brain is divided into areas, each containing many millions of neurons connected across thousands of synapses.

12 Apr 2023

Transcription of genes is fast but sloppy in old age

In a large joint project, a total of six research groups from the University of Cologne Cluster of Excellence on Cellular Stress Responses in Age-Associated Diseases (CECAD), the Max Planck Institute for Biology of Aging (MPI) in Cologne and the University of Göttingen have demonstrated the following findings which apply across the animal kingdom: with increasing age, the transcriptional elongation speed of genes increases, whereby the quality of the gene products suffers.

12 Apr 2023

Researchers conduct experiments comparing de novo proteins with computer-generated proteins

Proteins are components of every cell. How they have changed in the course of evolution for the purpose of taking on new functions in the body, has long been a subject of research.

12 Apr 2023

UC-led research team receives NIH grant to study the role of an enzyme in lysosome function

Once thought of as having one simple job within cells, researchers continue to learn more about the importance of organelles called lysosomes.

11 Apr 2023

Molecular & Structural Biology

Study reveals a previously unknown mechanism for DNA folding

New drug could effectively disarm multidrug-resistant bacteria

Study reveals DCAF1 protein's role in colon cancer development through EZH2 phosphorylation

U-M researcher launches new project to identify the full range of RNA building blocks inside human cells

Researchers discover the molecule responsible for guiding T cells toward tumors

Scientists discover a protein domain that could lead to new COVID-19 treatments

Study shows how a biological clock molecule contributes to lung scarring

Study reveals molecular mechanisms that give bacteria its 'superpowers' against antibiotics

Study offers novel insights into reducing adverse effects of antibiotics on the gut microbiome

How SARS-CoV-2 Omicron subvariants have evolved to evade host T-cell immunity

Study uncovers a novel fold within the SARS-CoV-2 replication co-factor non-structural protein 9

Study uncovers hallmarks to improving pancreatic cancer therapy

Genomic study reveals Babesia duncani's pathogenicity and virulence

Research reveals molecular features of rare mtDNA mutations

From Sanger Sequencing to the Human Genome Project: The Evolution of DNA Sequencing Technology

The virological characteristics of XBB.1.16

Salk study opens an entirely new way of thinking about cognitive decline

Transcription of genes is fast but sloppy in old age

Researchers conduct experiments comparing de novo proteins with computer-generated proteins

UC-led research team receives NIH grant to study the role of an enzyme in lysosome function

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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