Molecular & Structural Biology

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Study reveals the underlying mechanism by which TKI cancer drugs cause inflammation

Tyrosine kinase inhibitors are a type of targeted cancer medicine that can attack specific types of cancer cells and prevent them from multiplying.

17 Mar 2023

How the structural and functional effects of mutations on androgen receptor lead to prostate cancer

The androgen receptor is a key transcriptional factor for the proper sex development —specially in males— and the physiological balance of all the tissues that express this receptor.

17 Mar 2023

Structure of cellular shredders varies according to cell type, study shows

"Miniature shredders" are at work in each cell, disassembling and recycling cell components that are defective or no longer required.

16 Mar 2023

Chemists reveal a whole new role for molecular mirroring

With the aid of some sea slugs, University of Nebraska–Lincoln chemists have discovered that one of the smallest conceivable tweaks to a biomolecule can elicit one of the grandest conceivable consequences: directing the activation of neurons.

15 Mar 2023

Research reveals the modulatory effect of anti-inflammatory metabolite on immune cells

Researchers have revealed the modulatory effect of the anti-inflammatory metabolite itaconate on T helper and T regulatory cells, which may lead to new therapeutic approaches to treating some autoimmune diseases.

15 Mar 2023

Reversing infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein

Houston Methodist scientists reversed infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein, showing further evidence that links high cholesterol to female infertility.

15 Mar 2023

Study paves way for developing effective ASO therapies for brain diseases with fewer side effects

A promising therapy for a range of brain diseases involves antisense oligonucleotides (ASOs)-;specialized molecules that can modulate RNA and alter protein production-;directly injected into the cerebrospinal fluid, in the space around the brain and spinal cord.

14 Mar 2023

Super-resolution microscopy method for faster imaging of molecular structures in 3D

LMU researchers have developed a super-resolution microscopy method for the rapid differentiation of molecular structures in 3D.

10 Mar 2023

Study reveals molecular basis of how CAMSAP3 protein stabilizes microtubules within cells

Like poles support a tent, microtubules-;hollow cylindrical structures made of tubulin protein-;support eukaryotic cells.

9 Mar 2023

UVA scientists identify a detox approach to delay aging

University of Virginia scientists have identified a promising approach to delay aging by detoxifying the body of glycerol and glyceraldehyde, harmful by-products of fat that naturally accumulate over time.

9 Mar 2023

Newly found protein complex plays a crucial role in messenger RNA stability

Two proteins come together to protect and stabilize RNA as it carries muscle-forming code through the cell. Further understanding this RNA-stabilizing complex may have implications for influencing muscle recovery and disease treatment.

9 Mar 2023

C-reactive protein has a beneficial function in systemic lupus erythematosus

The biological function of the C-reactive protein, CRP, has long been unknown. Researchers at Linköping University in Sweden now show that this protein has a beneficial function in systemic lupus erythematosus, SLE, an inflammatory disease.

9 Mar 2023

Connection between mitochondrial metabolite and activation of inflammatory response revealed

A new study shows for the first time a connection between a mitochondrial metabolite and the activation of an inflammatory response.

8 Mar 2023

Novel molecular mechanism responsible for common form of acquired hydrocephalus discovered

Mass General researchers have discovered a novel molecular mechanism responsible for the most common forms of acquired hydrocephalus, potentially opening the door to the first-ever nonsurgical treatment for a life-threatening disease that affects about a million Americans.

8 Mar 2023

Study unveils a key factor involved in the DNA damage response and repair

A research team, affiliated with UNIST has unveiled a key factor involved in the DNA damage response (DDR), homologous recombination (HR) and DNA interstrand crosslink (ICL) repair.

8 Mar 2023

Newfound mechanism helps the heart to toggle between maintenance and energy-boost mode

Researchers at the Centre for Genomic Regulation in Barcelona have discovered a mechanism involving ribosomes which helps the heart toggle between a 'regular maintenance mode' for day-to-day function and an 'energy-boost mode' which aids recovery for high-demand situations including heart attacks.

7 Mar 2023

Mutant mice models created for studying bipolar disorder

Bipolar disorder (BD) is a debilitating condition characterized by alternating states of depression (known as depressive episodes) and abnormal excitement or irritability (known as manic episodes).

7 Mar 2023

Researchers investigate the potential effect of folic acid supplementation on DNA mutation rates

It is well established that folic acid supplementation can significantly reduce the risk of birth defects, including neural tube defects like spina bifida, the most common birth defect of the central nervous system and the second most common of all structural birth defects.

6 Mar 2023

Researchers synthesize fluorescent molecularly imprinted polymeric nanoparticles to detect neurotransmitters

The animal brain consists of tens of billions of neurons or nerve cells that perform complex tasks like processing emotions, learning, and making judgments by communicating with each other via neurotransmitters.

3 Mar 2023

New method enables direct observation of bee brains

An international team of bee researchers involving Heinrich Heine University Düsseldorf has integrated a calcium sensor into honey bees to enable the study of neural information processing including response to odors.

3 Mar 2023

Molecular & Structural Biology

Study reveals the underlying mechanism by which TKI cancer drugs cause inflammation

How the structural and functional effects of mutations on androgen receptor lead to prostate cancer

Structure of cellular shredders varies according to cell type, study shows

Chemists reveal a whole new role for molecular mirroring

Research reveals the modulatory effect of anti-inflammatory metabolite on immune cells

Reversing infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein

Study paves way for developing effective ASO therapies for brain diseases with fewer side effects

Super-resolution microscopy method for faster imaging of molecular structures in 3D

Study reveals molecular basis of how CAMSAP3 protein stabilizes microtubules within cells

UVA scientists identify a detox approach to delay aging

Newly found protein complex plays a crucial role in messenger RNA stability

C-reactive protein has a beneficial function in systemic lupus erythematosus

Connection between mitochondrial metabolite and activation of inflammatory response revealed

Novel molecular mechanism responsible for common form of acquired hydrocephalus discovered

Study unveils a key factor involved in the DNA damage response and repair

Newfound mechanism helps the heart to toggle between maintenance and energy-boost mode

Mutant mice models created for studying bipolar disorder

Researchers investigate the potential effect of folic acid supplementation on DNA mutation rates

Researchers synthesize fluorescent molecularly imprinted polymeric nanoparticles to detect neurotransmitters

New method enables direct observation of bee brains

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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