Molecular & Structural Biology

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Understanding Mtb's nitrogen metabolism could pave the way for more effective TB treatments

Development of new drugs to effectively target the bacterium that causes tuberculosis (TB) could be one step closer following an important discovery from the University of Surrey.

27 Mar 2023

New technology can rapidly analyze the metabolic state of lipids in cells

Professor Itaru Hamachi, Lecturer Tomonori Tamura, and Assistant Professor Masaki Tsuchiya of Kyoto University have developed a new technology called O-ClickFC (Organelle-selective click labeling with flow cytometry), which can, at a very high speed, analyze the metabolic state of lipids in cells.

27 Mar 2023

Mea6 elimination in oligodendrocytes impairs white matter structure and lipid content

More than half amount in adult human brain is made up of white matter. Lipid-rich myelin is a special structure formed by oligodendrocytes wrapping neuronal axons to form the major components of white matter.

27 Mar 2023

Cryo-EM provides structural insights into a specific protein involved in Hailey-Hailey disease

Hailey-Hailey disease is a rare, inherited condition characterized by patches of blisters appearing mainly in the skin folds of the arm pits, groin and under the breasts.

24 Mar 2023

Antibodies produced by newly developed mRNA vaccines are transferred from pregnant rabbits to offspring

Newly developed mRNA vaccines against Zika virus and HIV-1 produced strong antibody responses that transferred from pregnant rabbits to their offspring, researchers report March 24th in the journal Molecular Therapy.

24 Mar 2023

New high resolution model of the human hippocampus CA1 area developed

A new high resolution model of the CA1 region of the human hippocampus has been developed by the Institute of Biophysics of the Italian National Research Council and University of Modena e Reggio Emilia, part of the Human Brain Project.

24 Mar 2023

Candida auris escapes innate immunity through metabolic reprogramming

A team of scientists from Australia and Israel demonstrates that Candida auris, a fungus associated with life-threatening and drug-resistant infections, escapes the host's innate immune response by destroying macrophages through metabolic reprogramming. The fungus is also capable of escaping antimicrobial inflammatory response.

23 Mar 2023

Genes known to control eye color are essential for retinal health

Metabolic pathways consist of a series of biochemical reactions in cells that convert a starting component into other products.

23 Mar 2023

Modulating the function of immune cells to recover aging muscle's regenerative capacity

Muscle is able to regenerate through a process that involves multiple steps and players, including the immune system.

23 Mar 2023

New way to safely, sustainably synthesize a molecule with remarkable anticancer properties

Plants produce all types of curious chemicals. Some deter predators. Some smell wonderful. Some even have medicinal value.

23 Mar 2023

Study outlines a meta-scale approach to quantifying the human proteome

A major puzzle of biology is that while the human genome contains roughly 20,000 genes, many comparatively primitive organisms -; including the universally-studied worm C. elegans -; have almost the same number of genes.

23 Mar 2023

Understanding the structure of CFTR could help design more effective therapies for cystic fibrosis

Scientists at St. Jude Children's Research Hospital and Rockefeller University have combined their expertise to gain a better understanding of the cystic fibrosis transmembrane conductance regulator (CFTR).

23 Mar 2023

Study discovers a protein controlling resistance to chemotherapy

Despite the recent development of new targeted therapies, chemotherapies remain the most frequently used treatment to treat patients suffering from advanced cancers.

22 Mar 2023

Researchers discover how a single mechanosensitive protein induces fibrosis

Researchers from Kyushu University have found how a single mechanosensitive protein induces the process that thickens and scars tissue, known as fibrosis. The protein, called VGLL3, was shown to contribute to fibrosis in multiple organs.

22 Mar 2023

New insights into how the brain's 'internal compass' works

Scientists have gained new insights into the part of the brain that gives us a sense of direction, by tracking neural activity with the latest advances in brain imaging techniques.

22 Mar 2023

Age-induced methylation changes in the sperm epigenome contribute to offspring's medical problems

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, "Age-related methylation changes in the human sperm epigenome."

21 Mar 2023

AI-based design method synthesizes polymers that mimic blood plasma

Most life on Earth is based on polymers of 20 amino acids that have evolved into hundreds of thousands of different, highly specialized proteins. They catalyze reactions, form backbone and muscle and even generate movement.

20 Mar 2023

Using unsupervised machine learning algorithms to classify osteosarcoma

A new editorial paper was published in Oncotarget's Volume 14 on February 11, 2023, entitled, "Unlocking the potential of molecular-driven stratification for osteosarcoma treatment and prognosis."

20 Mar 2023

Novel RNA sense-and-respond circuit harnesses the force of enzymes to develop better drugs

More than twelve billion doses of mRNA vaccines have been administered globally since the start of the COVID pandemic, saving millions of lives. But RNA-based therapies for other diseases have so far proven more challenging to develop.

20 Mar 2023

Decreased viral infection severity in females may be due to extra copy of X chromosome-linked gene

It has long been known that viral infections can be more severe in males than females, but the question as to why has remained a mystery – until possibly now.

17 Mar 2023

Molecular & Structural Biology

Understanding Mtb's nitrogen metabolism could pave the way for more effective TB treatments

New technology can rapidly analyze the metabolic state of lipids in cells

Mea6 elimination in oligodendrocytes impairs white matter structure and lipid content

Cryo-EM provides structural insights into a specific protein involved in Hailey-Hailey disease

Antibodies produced by newly developed mRNA vaccines are transferred from pregnant rabbits to offspring

New high resolution model of the human hippocampus CA1 area developed

Candida auris escapes innate immunity through metabolic reprogramming

Genes known to control eye color are essential for retinal health

Modulating the function of immune cells to recover aging muscle's regenerative capacity

New way to safely, sustainably synthesize a molecule with remarkable anticancer properties

Study outlines a meta-scale approach to quantifying the human proteome

Understanding the structure of CFTR could help design more effective therapies for cystic fibrosis

Study discovers a protein controlling resistance to chemotherapy

Researchers discover how a single mechanosensitive protein induces fibrosis

New insights into how the brain's 'internal compass' works

Age-induced methylation changes in the sperm epigenome contribute to offspring's medical problems

AI-based design method synthesizes polymers that mimic blood plasma

Using unsupervised machine learning algorithms to classify osteosarcoma

Novel RNA sense-and-respond circuit harnesses the force of enzymes to develop better drugs

Decreased viral infection severity in females may be due to extra copy of X chromosome-linked gene

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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