Molecular & Structural Biology

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Hyperactive microglia can have a protective effect in the course of neurodegenerative diseases

Findings by researchers from Germany support the view that hyperactive immune cells in the brain can have a protective effect in the course of neurodegenerative diseases.

14 Feb 2022

Hundreds of new proteins that could play a role in cystic fibrosis discovered

Researchers at the University of Toronto have identified hundreds of new proteins that could play a role in cystic fibrosis, and which may shed light on why some patients respond better than others to current therapies.

14 Feb 2022

Physicists investigate the usefulness of gene expression tests for cancer therapy

Following surgery, patients with breast cancer are faced with the question of whether additional chemotherapy is necessary and really effective.

14 Feb 2022

Molecular cage helps researchers to get atomic-level details of key cancer protein

Acute myeloid leukemia (AML), the American Cancer Institute estimates, will affect more than 20,000 Americans this year and kill more than 11,000 of them.

11 Feb 2022

Circadian cycle controls the brain's ability to clear a protein linked to Alzheimer's disease

The brain's ability to clear a protein closely linked to Alzheimer's disease is tied to our circadian cycle, according to research published today in PLOS Genetics.

11 Feb 2022

Research reveals key role of p53 protein in epithelial migration and tissue repair

New research led by the University of Bristol has found the protein p53 plays a key role in epithelial migration and tissue repair.

11 Feb 2022

Novel molecule shows ability to inhibit the replication of all coronaviruses

Uppsala researchers have succeeded in designing a molecule that inhibits the replication of coronaviruses and that has great potential for development into a drug suitable for treating COVID-19.

10 Feb 2022

Researchers identify and characterize a previously unrecognized key player in cancer evolution

Researchers led by bioengineers at the University of California San Diego have identified and characterized a previously unrecognized key player in cancer evolution: clusters of mutations occurring at certain regions of the genome.

9 Feb 2022

Impact of genetic changes in Omicron variant on an immunodominant T-cell epitope

Researchers describe the impact of changes in the Omicron variant on a uniquely immunodominant spike-encoded CD8+ T-cell epitope.

9 Feb 2022

Researchers discover a molecular indicator and regulator of social isolation in female mice

As we have experienced during the COVID pandemic, loneliness, or perceived social isolation, is a major stress for social animals and increases the risk of various mental and physical health issues such as depression, substance abuse, obesity, and premature death.

9 Feb 2022

Reducing mucin secretion provides a way to control chemoresistance of colorectal cancers

Drugs which are commonly-used as the first line of treatment for colorectal cancer cause the tumor cells to oversecrete proteins known as mucins, according to a new study published today in the journal eLife.

9 Feb 2022

Defective mitochondrial DNA could be modified using gene-editing techniques

Defective mitochondria – the 'batteries' that power the cells of our bodies – could in future be repaired using gene-editing techniques.

8 Feb 2022

New method decodes the role of DDX41 protein in preventing double-strand breaks in DNA

There are many different ways in which the genetic material DNA can be damaged, resulting in the development of diseases such as cancer. Certain forms of DNA damage are associated with so-called R-loops.

8 Feb 2022

Genetically informed brain atlases help identify hundreds of genomic loci

An international team of scientists has used atlases of the human brain informed by genetics to identify hundreds of genomic loci. Loci is plural for locus, and in genetics indicates the physical location of a gene or variant on a chromosome.

7 Feb 2022

Dopamine signaling promotes the development of compulsive reward seeking behavior

Northwestern investigators have discovered that dopamine signaling in the brain's dorsomedial striatum promotes the development of compulsive behaviors in animal models, according to findings published in Current Biology.

7 Feb 2022

USP22 crucial for type III interferon signaling and SARS-CoV-2 infection

In a recent study posted to the bioRxiv* pre-print server, a team of researchers demonstrated that ubiquitin-specific peptidase 22 (USP22) is a crucial regulator of basal interferon (IFN) signaling in native human intestinal epithelial cells (hIECs).

7 Feb 2022

A novel approach to predict mutations within the SARS-CoV-2 spike

A study posted recently to the bioRxiv* preprint server demonstrated that the emergence of new spike variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) can be predicted.

6 Feb 2022

Scientists reveal how droplets of transcription factors collectively read DNA regions to switch on genes

Life starts with one cell. When an organism develops, dividing cells specialize to form the variety of tissues and organs that build up the adult body, while keeping the same genetic material – contained in our DNA.

6 Feb 2022

Researchers investigate how messenger substances signal inflammation during damaged cell removal

A research team from Cologne and Osnabrück has investigated in detail how messenger substances signal inflammation during the removal of damaged cells in the body.

4 Feb 2022

Scientists elucidate the structure of central cellular inflammatory switch

Researchers at the Universities of Bonn and Regensburg have elucidated the structure of a central cellular inflammatory switch.

4 Feb 2022

Molecular & Structural Biology

Hyperactive microglia can have a protective effect in the course of neurodegenerative diseases

Hundreds of new proteins that could play a role in cystic fibrosis discovered

Physicists investigate the usefulness of gene expression tests for cancer therapy

Molecular cage helps researchers to get atomic-level details of key cancer protein

Circadian cycle controls the brain's ability to clear a protein linked to Alzheimer's disease

Research reveals key role of p53 protein in epithelial migration and tissue repair

Novel molecule shows ability to inhibit the replication of all coronaviruses

Researchers identify and characterize a previously unrecognized key player in cancer evolution

Impact of genetic changes in Omicron variant on an immunodominant T-cell epitope

Researchers discover a molecular indicator and regulator of social isolation in female mice

Reducing mucin secretion provides a way to control chemoresistance of colorectal cancers

Defective mitochondrial DNA could be modified using gene-editing techniques

New method decodes the role of DDX41 protein in preventing double-strand breaks in DNA

Genetically informed brain atlases help identify hundreds of genomic loci

Dopamine signaling promotes the development of compulsive reward seeking behavior

USP22 crucial for type III interferon signaling and SARS-CoV-2 infection

A novel approach to predict mutations within the SARS-CoV-2 spike

Scientists reveal how droplets of transcription factors collectively read DNA regions to switch on genes

Researchers investigate how messenger substances signal inflammation during damaged cell removal

Scientists elucidate the structure of central cellular inflammatory switch

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