Molecular & Structural Biology

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Mutations in histone regulator protein linked to rare neurodevelopmental disorder, cancers

Mutations in a histone regulator protein are linked to both a rare neurodevelopmental disorder and to some cancers, according to a study published in the journal Genes and Development.

16 Dec 2021

Novel imaging method used to map glycosylation patterns linked with Alzheimer’s disease

Using new methodology, University of Kentucky researchers have mapped the variations in sugar chains attached to brain proteins from deceased healthy individuals or individuals with Alzheimer's disease.

15 Dec 2021

SARS-CoV-2 VOCs dependent on IFITM2 for efficient infection establishment

Researchers demonstrate that the Alpha, Beta, Gamma, and Delta variants of SARS-CoV-2 require endogenous IFITM2 expression for efficient replication.

15 Dec 2021

Interaction between SARS-CoV-2 N-protein and Parkinson's protein speeds up amyloid formation

Case reports of relatively young COVID-19 patients who developed Parkinson's disease within weeks of contracting the virus have led scientists to wonder if there could be a link between the two conditions.

14 Dec 2021

Study reveals molecular players involved in the onset of leukemia

A new study led by João T. Barata from Instituto de Medicina Molecular João Lobo Antunes (iMM, Portugal), and J. Andrés Yunes from Centro Infantil Boldrini (Brazil), published now in the scientific journal Nature Communications, shows that changes in a protein called IL-7R are sufficient to initiate a type of leukemia.

14 Dec 2021

Scientists trace neuronal activity when the brain switches from hearing to listening

What happens in the brain when simply hearing becomes listening? To answer this question, researchers at the University of Basel have traced the neuronal fingerprint of the two types of sound processing in the mouse brain.

14 Dec 2021

Flawed genetic switches could be at the origin of malformations or developmental diseases

Embryonic development follows delicate stages: for everything to go well, many genes must coordinate their activity according to a very meticulous scheme and tempo. This precision mechanism sometimes fails, leading to more or less disabling malformations.

14 Dec 2021

Protein can protect the heart from damage following cancer treatment

Cancer treatment can be tough on the body, but for the patient to survive the cancer, it's often necessary to go through with the treatment anyway.

13 Dec 2021

Study demonstrates SARS-CoV-2 ORF6 localization and interferon antagonism as independent events

Researchers deploy mutagenesis studies to investigate the relationship between ORF6 localization and IFN antagonism.

12 Dec 2021

Effect of mutations on SARS-CoV-2 E protein interactions with cell junctions

In a recent study, ten human PDZ-containing proteins showed significant interactions with the SARS-CoV-2 E protein in a PBM-dependent manner.

12 Dec 2021

Study provides better understanding of the degenerative underpinnings of Parkinson’s disease

Northwestern investigators have discovered the molecular signature of a subset of dopaminergic neurons with an increased vulnerability to degeneration.

12 Dec 2021

Apterous protein plays a crucial double role in retaining memories, study reveals

Researchers from Tokyo Metropolitan University have gained insights into the biochemistry of long-term memory. Studying fruit flies, they found that the Apterous (Ap) protein plays a crucial double role in retaining memories.

12 Dec 2021

Researchers recapitulate the human form of arrhythmogenic cardiomyopathy in zebrafish model

The research groups of Jeroen Bakkers (Hubrecht Institute/UMC Utrecht) and Toon van Veen (UMC Utrecht) bring forward the first patient-specific model for the heart disease arrhythmogenic cardiomyopathy (ACM).

9 Dec 2021

SARS-CoV-2 Omicron variant may bind with ACE2 receptor more efficiently

A new study discusses the effect of the Omicron variant’s mutations on its binding efficiency to the ACE2 receptor.

9 Dec 2021

Scientists determine structure of the molecule associated with ALS for the first time

Scientists have determined for the first time the structure of the molecule associated with amyotrophic lateral sclerosis (ALS) and multiple other neurodegenerative diseases.

9 Dec 2021

Study reveals how a protein in the blood is attracted to key component of Adenovirus-based vaccines

A collaborative team from the School of Medicine at the University of Cardiff, Wales and a range of US institutions used the UK's national synchrotron, Diamond Light Source, to help reveal the details of how a protein in the blood is attracted to a key component of Adenovirus based vaccines.

8 Dec 2021

Molecular & Structural Biology

Mutations in histone regulator protein linked to rare neurodevelopmental disorder, cancers

Novel imaging method used to map glycosylation patterns linked with Alzheimer’s disease

SARS-CoV-2 VOCs dependent on IFITM2 for efficient infection establishment

Interaction between SARS-CoV-2 N-protein and Parkinson's protein speeds up amyloid formation

Study reveals molecular players involved in the onset of leukemia

Scientists trace neuronal activity when the brain switches from hearing to listening

Flawed genetic switches could be at the origin of malformations or developmental diseases

Protein can protect the heart from damage following cancer treatment

Study demonstrates SARS-CoV-2 ORF6 localization and interferon antagonism as independent events

Effect of mutations on SARS-CoV-2 E protein interactions with cell junctions

Study provides better understanding of the degenerative underpinnings of Parkinson’s disease

Apterous protein plays a crucial double role in retaining memories, study reveals

Researchers recapitulate the human form of arrhythmogenic cardiomyopathy in zebrafish model

SARS-CoV-2 Omicron variant may bind with ACE2 receptor more efficiently

Scientists determine structure of the molecule associated with ALS for the first time

Study reveals how a protein in the blood is attracted to key component of Adenovirus-based vaccines

Researchers identify a molecular culprit for COVID-19's seasonal nature

Researchers uncover the journey of microglia in developing zebrafish

SARS-CoV-2 Delta variant changes receptor binding domain conformation to escape host antibodies

Study shows the existence of efficient coding processes for visual stimuli in rodents

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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