Molecular & Structural Biology

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Cryo-EM reveals how the DNA replication machinery assembles at DNA damage sites

Cryogenic electron microscopy (cryo-EM) has enabled researchers to study how the DNA replication machinery assembles at sites where DNA is damaged.

22 Nov 2021

Other molecules may have greater potential as cancer therapies than gold complex auranofin

The gold complex auranofin has traditionally been used for treating rheumatism but is also being evaluated as a treatment for certain forms of cancer.

22 Nov 2021

Researchers identify mechanism behind regulation of large exon splicing during vertebrate evolution

In vertebrates, large exons often skip splicing events and are evolutionarily conserved. Scientists from Nagoya University, Japan, led by Associate Professor Akio Masuda, have recently identified the mechanism behind regulated splicing of large constitutive exons which are rich in disordered regions, and their potential involvement in the assembly of transcription factors.

21 Nov 2021

New study uncovers a mechanism of sleep in zebrafish

Why do humans spend a third of their lives sleeping? Why do animals sleep? Throughout evolution sleep has remained universal and essential to all organisms with a nervous system, including invertebrates such as flies, worms, and even jellyfish.

21 Nov 2021

A trio of proteins found to drive inflammation in psoriasis

About 7.5 million Americans suffer from psoriasis, an autoimmune disease that shows up as patches of red, inflamed skin and painful, scaly rashes. Although there are effective treatments for psoriasis, not everyone responds to these therapies-;and for many, the relief is temporary.

21 Nov 2021

Novel technique solves structure of the HIV capsid alone and in complex with host factors

A new technique using electron tomography and subtomogram averaging at Diamond's electron Bio-Imaging Centre (eBIC), has solved the structure of the HIV capsid alone and in complex with host factors.

21 Nov 2021

Study reveals molecular architecture of fungal cell walls and structural responses to stress

In a new study published in Nature Communications, Associate Professor Tuo Wang and his research team from the Department of Chemistry at Louisiana State University revealed the molecular architecture of fungal cell walls and the structural responses to stresses, aiding the development of antifungal drugs targeting cell wall components.

21 Nov 2021

Scientists unravel near-atomic-scale structure of depression-linked brain receptor

Scientists at Scripps Research, Florida have determined the near-atomic-scale structure of an unusual brain-cell receptor called GPR158, which has been linked to depression and anxiety.

20 Nov 2021

Repurposed ALS drug could slow gradual brain cell loss in Niemann-Pick disease type C1

Riluzole, a drug approved to treat amyotrophic lateral sclerosis (ALS), a disease affecting nerve cells controlling movement, could slow the gradual loss of a particular brain cell that occurs in Niemann-Pick disease type C1 (NPC1), a rare genetic disorder affecting children and adolescents, suggests a study in mice by scientists at the National Institutes of Health.

20 Nov 2021

Study reveals complex interplay between diet, gut microbiota, and immune function

The cliché "you are what you eat" has been used for hundreds of years to illustrate the link between diet and health. Now, an international team of researchers has found the molecular proof of this concept, demonstrating how diet ultimately affects immunity through the gut microbiome.

17 Nov 2021

P681H mutation helps SARS-CoV-2 VOCs replicate faster and resist innate immunity

In the current study, researchers compare the IFITM sensitivities of major SARS-CoV-2 VOCs.

17 Nov 2021

Researchers identify new group of antibacterial molecules

Researchers at Karolinska Institutet, Umeå University, and the University of Bonn have identified a new group of molecules that have an antibacterial effect against many antibiotic-resistant bacteria.

17 Nov 2021

Study may help predict genomic changes that may happen in advanced cancers based on therapy

A novel way to look at cancer treatment resistance offers the possibility for identifying genetic mechanisms involved and alternative treatment approaches.

17 Nov 2021

Scientists predict structures of eukaryotic protein complexes using AI

UT Southwestern and University of Washington researchers led an international team that used artificial intelligence (AI) and evolutionary analysis to produce 3D models of eukaryotic protein interactions.

17 Nov 2021

Researchers shed light on how brain cells ‘navigate’ during the day and night

To navigate successfully in an environment, you need to continuously track the speed and direction of your head, even in the dark.

16 Nov 2021

Discovery of new receptor that interacts with SARS-CoV-2 spike, suppresses infection

Researchers recently conducted a study to identify host factors affecting cellular interactions of the SARS-CoV-2 spike protein.

16 Nov 2021

Histone mimicry as a mechanism through which SARS-CoV-2 disrupts host cell epigenetic regulation

A recent study investigates histone mimicry as a mechanism by SARS-CoV-2 for disrupting epigenetic regulation to evade host cell responses to infection.

15 Nov 2021

Machine learning analysis of long non-coding RNAs reveals new prognostic cancer biomarkers

A new batch of prognostic cancer biomarkers have been discovered in an area where few have gone looking before. Researchers have unveiled a catalogue of 166 prognostic biomarkers, generated by analyzing long non-coding RNAs (lncRNAs) – which are understudied in cancer research.

15 Nov 2021

Study analyzes the health effects of a patented DGA compound

A study conducted at the University of Jyväskylä analyzed the health effects of a patented DGA compound and compared them to the effects of exercise.

15 Nov 2021

Researchers discover new gene critical for daily behavioral rhythms

Life is organized on a 24-hour schedule. Central to this regular rhythm is the circadian clock, timekeepers that are present in virtually every organ, tissue and cell type. When a clock goes awry, sleep disruption or a variety of diseases can result.

15 Nov 2021

Molecular & Structural Biology

Cryo-EM reveals how the DNA replication machinery assembles at DNA damage sites

Other molecules may have greater potential as cancer therapies than gold complex auranofin

Researchers identify mechanism behind regulation of large exon splicing during vertebrate evolution

New study uncovers a mechanism of sleep in zebrafish

A trio of proteins found to drive inflammation in psoriasis

Novel technique solves structure of the HIV capsid alone and in complex with host factors

Study reveals molecular architecture of fungal cell walls and structural responses to stress

Scientists unravel near-atomic-scale structure of depression-linked brain receptor

Repurposed ALS drug could slow gradual brain cell loss in Niemann-Pick disease type C1

Study reveals complex interplay between diet, gut microbiota, and immune function

P681H mutation helps SARS-CoV-2 VOCs replicate faster and resist innate immunity

Researchers identify new group of antibacterial molecules

Study may help predict genomic changes that may happen in advanced cancers based on therapy

Scientists predict structures of eukaryotic protein complexes using AI

Researchers shed light on how brain cells ‘navigate’ during the day and night

Discovery of new receptor that interacts with SARS-CoV-2 spike, suppresses infection

Histone mimicry as a mechanism through which SARS-CoV-2 disrupts host cell epigenetic regulation

Machine learning analysis of long non-coding RNAs reveals new prognostic cancer biomarkers

Study analyzes the health effects of a patented DGA compound

Researchers discover new gene critical for daily behavioral rhythms

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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