Molecular & Structural Biology

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Repurposed ALS drug could slow gradual brain cell loss in Niemann-Pick disease type C1

Riluzole, a drug approved to treat amyotrophic lateral sclerosis (ALS), a disease affecting nerve cells controlling movement, could slow the gradual loss of a particular brain cell that occurs in Niemann-Pick disease type C1 (NPC1), a rare genetic disorder affecting children and adolescents, suggests a study in mice by scientists at the National Institutes of Health.

20 Nov 2021

Study reveals complex interplay between diet, gut microbiota, and immune function

The cliché "you are what you eat" has been used for hundreds of years to illustrate the link between diet and health. Now, an international team of researchers has found the molecular proof of this concept, demonstrating how diet ultimately affects immunity through the gut microbiome.

17 Nov 2021

P681H mutation helps SARS-CoV-2 VOCs replicate faster and resist innate immunity

In the current study, researchers compare the IFITM sensitivities of major SARS-CoV-2 VOCs.

17 Nov 2021

Researchers identify new group of antibacterial molecules

Researchers at Karolinska Institutet, Umeå University, and the University of Bonn have identified a new group of molecules that have an antibacterial effect against many antibiotic-resistant bacteria.

17 Nov 2021

Study may help predict genomic changes that may happen in advanced cancers based on therapy

A novel way to look at cancer treatment resistance offers the possibility for identifying genetic mechanisms involved and alternative treatment approaches.

17 Nov 2021

Scientists predict structures of eukaryotic protein complexes using AI

UT Southwestern and University of Washington researchers led an international team that used artificial intelligence (AI) and evolutionary analysis to produce 3D models of eukaryotic protein interactions.

17 Nov 2021

Researchers shed light on how brain cells ‘navigate’ during the day and night

To navigate successfully in an environment, you need to continuously track the speed and direction of your head, even in the dark.

16 Nov 2021

Discovery of new receptor that interacts with SARS-CoV-2 spike, suppresses infection

Researchers recently conducted a study to identify host factors affecting cellular interactions of the SARS-CoV-2 spike protein.

16 Nov 2021

Histone mimicry as a mechanism through which SARS-CoV-2 disrupts host cell epigenetic regulation

A recent study investigates histone mimicry as a mechanism by SARS-CoV-2 for disrupting epigenetic regulation to evade host cell responses to infection.

15 Nov 2021

Machine learning analysis of long non-coding RNAs reveals new prognostic cancer biomarkers

A new batch of prognostic cancer biomarkers have been discovered in an area where few have gone looking before. Researchers have unveiled a catalogue of 166 prognostic biomarkers, generated by analyzing long non-coding RNAs (lncRNAs) – which are understudied in cancer research.

15 Nov 2021

Study analyzes the health effects of a patented DGA compound

A study conducted at the University of Jyväskylä analyzed the health effects of a patented DGA compound and compared them to the effects of exercise.

15 Nov 2021

Researchers discover new gene critical for daily behavioral rhythms

Life is organized on a 24-hour schedule. Central to this regular rhythm is the circadian clock, timekeepers that are present in virtually every organ, tissue and cell type. When a clock goes awry, sleep disruption or a variety of diseases can result.

15 Nov 2021

Scientists develop a single-cell chromatin atlas for the human genome

Researchers at University of California San Diego have produced a single-cell chromatin atlas for the human genome.

14 Nov 2021

Higher order protein catenation leads to the development of artificial antibodies

Chemical topology is a unique dimension for protein engineering. Over the past few years, the discovery of topological nontrivial proteins in nature has already revealed their many potential functional benefits, such as enhanced thermal/mechanical/chemical stability.

12 Nov 2021

Molecular & Structural Biology

Repurposed ALS drug could slow gradual brain cell loss in Niemann-Pick disease type C1

Study reveals complex interplay between diet, gut microbiota, and immune function

P681H mutation helps SARS-CoV-2 VOCs replicate faster and resist innate immunity

Researchers identify new group of antibacterial molecules

Study may help predict genomic changes that may happen in advanced cancers based on therapy

Scientists predict structures of eukaryotic protein complexes using AI

Researchers shed light on how brain cells ‘navigate’ during the day and night

Discovery of new receptor that interacts with SARS-CoV-2 spike, suppresses infection

Histone mimicry as a mechanism through which SARS-CoV-2 disrupts host cell epigenetic regulation

Machine learning analysis of long non-coding RNAs reveals new prognostic cancer biomarkers

Study analyzes the health effects of a patented DGA compound

Researchers discover new gene critical for daily behavioral rhythms

Scientists develop a single-cell chromatin atlas for the human genome

Higher order protein catenation leads to the development of artificial antibodies

Advanced technique reveals the ultrastructure of huntingtin inclusion bodies

GPR126 gene may play an essential role in placental development, study reveals

New study challenges the popular belief that gut microbiome drives autism

New discovery could lead to the creation of a pan-coronaviruses vaccine

Newly discovered RNA molecule protects mice from emerging SARS-CoV-2 variants

Ion channel mechanosensor plays a key role in regulating the speed of skin wound healing

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