Molecular & Structural Biology

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CRISPR screening tool pinpoints new therapeutic target to treat acute myeloid leukemia

A CRISPR screening tool identified a new therapeutic target to treat acute myeloid leukemia (AML) that has the potential to leave patients with fewer side effects than current approaches, according to a new study from Penn Medicine published online in Molecular Cell.

18 Aug 2021

Scientists propose innovative method to test the effectiveness of coronavirus medicines

South Ural State University scientists have proposed an innovative method for testing the effectiveness of medicines for coronavirus. According to the researchers, it is necessary to focus on the maximum coincidence of the ligand and the receptor. The results of the work have been published in the highly-rated journal "Molecules"(Q1).

18 Aug 2021

Protein implicated in tumor growth may protect against neurodegenerative diseases

Cells translate their genetic material at rapid rates with exquisite precision to reproduce, repair damage or even combat disease.

17 Aug 2021

Making the nanobody big again for Cryo-EM

Researchers describe the method that allows high-resolution structure determination of small proteins by single-particle cryo-EM using a Legobody.

17 Aug 2021

Study provides insight into fitness effects of genomic structural variants in natural populations

Molecular geneticists have known for about a decade that genomic structural variants can play important roles in the adaptation and speciation of both plants and animals, but their overall influence on the fitness of plant populations is poorly understood.

16 Aug 2021

SFI researchers take a broader view of life’s multiple origins

The history of life on Earth has often been likened to a four-billion-year-old torch relay. One flame, lit at the beginning of the chain, continues to pass on life in the same form all the way down.

16 Aug 2021

Brain’s structural and functional alignment can vary with sex, age and may be genetic, study suggests

The degree to which the brain's wiring aligns with its patterns of activity can vary with sex and age, and may be genetic, suggests a study published by Weill Cornell Medicine investigators. The study finds that this alignment may also have implications on cognition.

16 Aug 2021

Small protein prevents immune system from destroying pancreatic cells in type 1 diabetes-prone mice

A new study has shown that treating type 1 diabetes-prone mice with the small protein MOTS-c prevented the immune system from destroying insulin-producing pancreatic cells, effectively preventing the onset of the autoimmune disease.

16 Aug 2021

UH researcher set to explore how testosterone works in the brain

Most people have some idea about the hormone testosterone –how it regulates male behavior or how too little of it might cause a decrease in libido and too much might cause aggressive and irritable behavior. Turns out, no one yet knows how testosterone really does all that.

16 Aug 2021

Researchers assess the genetic features of T-cell immunity development to SARS-CoV-2 variants

The continuing emergence of new SARS-CoV-2 mutations allows the virus to spread more effectively and evade antibodies. However, it is unclear whether new strains are capable of evading T-cell immunity-; one of the body's main lines of defense against COVID-19.

16 Aug 2021

New system combines computer software and cryo-EM to determine 3D structures of RNA-only molecules

The single-stranded genetic material RNA is best known for guiding the assembly of proteins in our cells and carrying the genetic code for viruses like SARS-CoV-2 and HIV.

16 Aug 2021

Structure of BRCA2 protein complex critical for DNA repair solved

The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA.

13 Aug 2021

Novel CRISPR-based technique could inspire a new class of medical diagnostics

Scientists have repurposed the genetic modification technology CRISPR to identify antibodies in patient blood samples in a move that could inspire a new class of medical diagnostics in addition to a host of other applications.

13 Aug 2021

Study uncovers a subset of human short introns spliced out by a distinct mechanism

The interrupted non-coding regions in pre-mRNAs, termed “introns,” are excised by “splicing” to generate mature coding mRNAs that are translated into proteins.

13 Aug 2021

Innovative therapeutic platform for blood-to-brain delivery of antisense oligonucleotide therapy

Antisense oligonucleotide (ASO) therapy has the potential to ameliorate many neurodegenerative diseases at the genetic level to suppress the production of harmful proteins or non-coding RNAs.

12 Aug 2021

Study finds four circulating miRNAs which could effectively inhibit SARS-CoV-2 replication

In a new study, Chen-Yu Zhang's group from Nanjing University presents a rather striking finding that four circulating miRNAs, which are high in healthy people and much lower in older people and diabetic patients, could effectively inhibit SARS-CoV-2 replication by directly targeting the S protein.

12 Aug 2021

Researchers determine the structure of receptor involved in type 2 diabetes and other pathologies

Researchers from the University of Southern California, Merck & Co., Skoltech, MIPT, UCLA, and the Université de Sherbrooke have determined the structure of the human leukotriene B4 receptor 1, involved in inflammatory, infectious, allergic, and tumorigenic diseases.

12 Aug 2021

Molecular & Structural Biology

CRISPR screening tool pinpoints new therapeutic target to treat acute myeloid leukemia

Scientists propose innovative method to test the effectiveness of coronavirus medicines

Protein implicated in tumor growth may protect against neurodegenerative diseases

Making the nanobody big again for Cryo-EM

Study provides insight into fitness effects of genomic structural variants in natural populations

SFI researchers take a broader view of life’s multiple origins

Brain’s structural and functional alignment can vary with sex, age and may be genetic, study suggests

Small protein prevents immune system from destroying pancreatic cells in type 1 diabetes-prone mice

UH researcher set to explore how testosterone works in the brain

Researchers assess the genetic features of T-cell immunity development to SARS-CoV-2 variants

New system combines computer software and cryo-EM to determine 3D structures of RNA-only molecules

Structure of BRCA2 protein complex critical for DNA repair solved

Novel CRISPR-based technique could inspire a new class of medical diagnostics

Study uncovers a subset of human short introns spliced out by a distinct mechanism

Innovative therapeutic platform for blood-to-brain delivery of antisense oligonucleotide therapy

Study finds four circulating miRNAs which could effectively inhibit SARS-CoV-2 replication

Researchers determine the structure of receptor involved in type 2 diabetes and other pathologies

Study finds novel approach to attenuate mitochondrial dysfunction that drives diet-induced obesity

Skin cells could provide better understanding of molecular mechanisms of frontotemporal dementia

Brain memory signals may influence blood sugar levels, rat study finds

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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