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Nasal delivery of single-domain antibodies improves SARS-CoV-2 symptoms in animal model

In a recent study published in the journal PLOS Pathogens, scientists showed that nasal administration of a single-domain antibody (VHH), named K-874A, brought about inhibition of SARS-CoV-2 titers in infected lungs of Syrian hamsters.

19 Oct 2021

Scientists scan 110 natural compounds for SARS-CoV-2 antiviral potential

Phytochemicals are plant-derived molecules from medicinal plants that act as a prominent reservoir for treating a wide range of viral infections. In a new study, published in the journal Scientific Reports, scientists adopted a computational approach to identify Mpro inhibitors.

19 Oct 2021

Waning COVID vaccine efficacy especially against reinfection

A new study in American veterans posted to the medRxiv* preprint server suggests severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are less effective in preventing infection after six months. The decline was most significant with the Johnson & Johnson vaccine, with vaccine effectiveness plummeting from 88% to 3%.

19 Oct 2021

Factors contributing to a weak antibody response to the Pfizer COVID-19 vaccine

A new study discusses risk factors for the failure of seroconversion following full vaccination with the COVID-19 Pfizer vaccine.

18 Oct 2021

Watch: Going beyond the script of ‘Dopesick’ and America’s real-life opioid crisis

KHN and policy colleagues at our parent organization KFF teamed up with Hulu for a discussion of America’s opioid crisis, following the Oct. 13 premiere of the online streaming service's new series "Dopesick."

18 Oct 2021

New class of CXCR4 antagonists could prevent airway inflammation and atopic dermatitis

Aberrant CXCR4/CXCL12 signaling is involved in many pathophysiological processes such as cancer and inflammatory diseases. A natural fragment of serum albumin, named EPI-X4, has previously been identified as endogenous peptide antagonist andinverse agonistof CXCR4 and is a promising compound for the development of improved analogues for the therapy of CXCR4-associated diseases.

18 Oct 2021

Researchers identify common side effects of three COVID-19 vaccines

COVID-19 vaccines remain the best tool in the pandemic toolbox against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). But they are not perfect; reports have surfaced of mild to severe side effects after vaccination. A new study from researchers in the Lampe & Company GmbH & Co. KG compared the severity of adverse events from each coronavirus vaccine.

17 Oct 2021

Researchers explore how opioids may have become so widely abused

Researchers may have uncovered new answers on how to create safer opioids. Design a new opioid to bypass the part of brain that feels pleasure, but retain the analgesic properties, which make opioids one of the most effective pain relievers.

15 Oct 2021

Aspirin use daily by healthy adults could be harmful

Scientists determine if the daily use of aspirin prolongs a healthy life span that is defined as being free from dementia and physical disability.

14 Oct 2021

Anti-rheumatic drug as a potential candidate for treating COVID-19

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) produces inflammatory cytokine storms. But an FDA-approved anti-rheumatic drug, Auranofin, used to treat autoimmune and infectious diseases, may also help serve as an antiviral treatment for COVID-19 infection.

13 Oct 2021

‘Risky’ medicines should be stopped before patients leave hospital, researchers say

Hospital doctors and pharmacists should stop ‘risky’ medicines before patients leave hospital - according to researchers at the University of East Anglia.

13 Oct 2021

Medicinal plant extract could potentially help curb the opioid epidemic

The extract of the plant Corydalis yanhusuo prevents morphine tolerance and dependence while also reversing opiate addiction, according to a recent study led by the University of California, Irvine. The findings were published in the October issue of the journal Pharmaceuticals.

12 Oct 2021

Scientists develop an extremely potent siRNA with broad activity against SARS-CoVs

Researchers in Germany have developed a promising approach to suppressing the viral replication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19).

12 Oct 2021

Rapid measurement of SARS-CoV-2 spike T-cells

Researchers measure SARS-CoV-2 T-cell responses in individuals vaccinated or in those who developed immunity from a prior natural infection.

12 Oct 2021

The public backs Medicare Rx price negotiation even after hearing both sides’ views

As Congress debates cutting prescription drug costs, a poll released Tuesday found the vast majority of adults — regardless of their political party or age — support letting the federal government negotiate drug prices for Medicare beneficiaries and those in private health insurance plans.

12 Oct 2021

Pharmaceutical News

Nasal delivery of single-domain antibodies improves SARS-CoV-2 symptoms in animal model

Scientists scan 110 natural compounds for SARS-CoV-2 antiviral potential

Waning COVID vaccine efficacy especially against reinfection

Factors contributing to a weak antibody response to the Pfizer COVID-19 vaccine

Watch: Going beyond the script of ‘Dopesick’ and America’s real-life opioid crisis

New class of CXCR4 antagonists could prevent airway inflammation and atopic dermatitis

Researchers identify common side effects of three COVID-19 vaccines

Researchers explore how opioids may have become so widely abused

Aspirin use daily by healthy adults could be harmful

Anti-rheumatic drug as a potential candidate for treating COVID-19

‘Risky’ medicines should be stopped before patients leave hospital, researchers say

Medicinal plant extract could potentially help curb the opioid epidemic

Scientists develop an extremely potent siRNA with broad activity against SARS-CoVs

Rapid measurement of SARS-CoV-2 spike T-cells

The public backs Medicare Rx price negotiation even after hearing both sides’ views

COVID-19 vaccination elicits broader antibody response to SARS-CoV-2 spike than infection

Qatari study finds BNT162b2 vaccine effectiveness waning 6 months after second dose

Low risk of severe COVID-19 after first dose of Pfizer and AstraZeneca vaccines in Scotland

Quantifying the Impact of Powder Properties on Pharmaceutical Powders

Moderna COVID vaccine booster dose results in immune memory

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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