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Anti-cancer prodrug can benefit cancer patients

Unlike conventional cancer drugs that attack and kill cancer cells directly, anti-cancer immunotherapy, which kills cancer cells by strengthening the body's immunity, is a novel type of cancer treatment currently attracting increased attention. Unfortunately, a minority of cancer patients who have some degree of pre-existing immunity only benefit from anti-cancer immunotherapy.

28 Jun 2021

An oral pill for COVID-19? Molnupiravir shows promise

Recently, researchers reported molnupiravir as the first oral and direct-acting antiviral that is highly effective at reducing SARS-CoV-2 levels.

27 Jun 2021

Performance-enhancing substance use is longitudinally associated with criminal offending

Despite research showing associations between anabolic steroid use and criminal offending, the possibility of a similar association between legal performance-enhancing substance use, such as creatine, and criminal offending remained unknown.

25 Jun 2021

Comprehensive reference on the science, technology, and applications of postbiotics

Postbiotics: Science, Technology, and Applications explains essential and practical knowledge about postbiotics. Chapters cover the definition and classification of postbiotics, principal methods for preparing them, information about the main post biotic constituents and their biological activities and their clinical health benefits.

25 Jun 2021

Over-the-counter antacids may improve glucose levels in people with diabetes

Antacids improved blood sugar control in people with diabetes but had no effect on reducing the risk of diabetes in the general population, according to a new meta-analysis published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

25 Jun 2021

Remdesivir caused dangerously low heart rate in COVID-19 patients

After beginning treatment with remdesivir for COVID-19, a patient experienced significant bradycardia, or low heart rate. Her physicians used a dopamine infusion to stabilize her through the five-day course of remdesivir treatment, and her cardiac condition resolved itself at the end of the treatment.

25 Jun 2021

Many people with fibromyalgia substitute CBD for opioids and pain medications, finds study

Fibromyalgia is one of many chronic pain conditions that remains stubbornly difficult to treat.

24 Jun 2021

Antidepressants taken during pregnancy do not increase risk for autism spectrum disorder

Women with depression and other mood disorders are generally advised to continue taking antidepressant medications during pregnancy.

24 Jun 2021

Researchers reanalyze COVID RECOVERY trial data on tocilizumab

A Bayesian analysis of the RECOVERY trial suggests the immunosuppressive drug tocilizumab can reduce deaths in hospitalized COVID-19 patients taking corticosteroids as well as patients on oxygen or non-invasive ventilation and likely increases hospital discharge rates. However, it is not clear if patients on invasive ventilation also benefit.

24 Jun 2021

Bivalent DNA SARS-CoV-2 vaccine induces strong humoral and cellular immunity in mice

A team of UK-based scientists has developed and validated a DNA vaccine against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that encodes both spike receptor-binding domain (RBD) and nucleocapsid of the virus as vaccine immunogens.

24 Jun 2021

Scientists use new technology to optimize drug development for brain diseases

Dr. Hayder Amin and Dr. Caghan Kizil from the DZNE's Dresden site aim to speed up developing drugs against brain diseases through cutting-edge technology.

24 Jun 2021

Repurposing immunomodulatory drugs to treat COVID-19

EULAR has released new points to consider on the use of immunomodulatory drugs in the fight against severe COVID-19.

23 Jun 2021

Vaccine side effects should be viewed as a sign of efficacy, say immunologists

The rapid development of safe and efficacious vaccines against SARS-CoV-2 has offered hope that the global COVID-19 pandemic may soon be under control. However, vaccinations remain incomplete in many developed nations, and lag further still in the developing world.

23 Jun 2021

First spatial scan analysis helps identify hotspots of undervaccinated children

The map of Montana Kayla Irish pulls up is peppered with red circles, each cluster providing details behind one of today's timely topics - childhood vaccination.

23 Jun 2021

Statin use among heart failure patients can reduce cancer risk

Statin use among patients with heart failure is associated with a 16% lower risk of developing cancer compared with non-statin users during an average of four years of follow-up, according to new research published today (Wednesday) in the European Heart Journal.

23 Jun 2021

mRNA COVID-19 vaccines may increase patients' concerns about side effects

Vivid photos of the red "COVID arm" rash and reports of facial swelling in patients who have received dermatological fillers after Pfizer-BioNTech or Moderna vaccination for COVID-19 may increase patients' concerns about mRNA vaccine side effects and contribute to vaccine hesitancy.

23 Jun 2021

Clinicians report cases of rare neurological disorder following COVID-19 vaccination

In two separate articles in the Annals of Neurology, clinicians in India and England report cases of a rare neurological disorder called Guillain-Barre? syndrome after individuals were vaccinated against COVID-19.

22 Jun 2021

FDA approves oral pellets to treat children with venous thromboembolism

Today, the U.S. Food and Drug Administration approved Pradaxa (dabigatran etexilate) oral pellets to treat children 3 months to less than 12 years old with venous thromboembolism (a condition where blood clots form in the veins) directly after they have been treated with a blood thinner given by injection for at least five days.

21 Jun 2021

Effect of national tender system on the costs of biologic and targeted drugs in Norway

At the 2021 EULAR congress, Brkic and colleagues presented data from people with rheumatoid arthritis (RA)treated at Norwegian rheumatology outpatient clinics between 2010 and 2019.

21 Jun 2021

More research needed to clarify effects of cannabis on brain development of young adults with ADHD

At least so far, the currently limited research base does not establish that cannabis has additional adverse effects on brain development or functioning in adolescents or young adults with attention-deficit/hyperactivity disorder (ADHD), concludes a review in the July/August issue of Harvard Review of Psychiatry. The journal is published in the Lippincott portfolio by Wolters Kluwer.

21 Jun 2021

Pharmaceutical News

Anti-cancer prodrug can benefit cancer patients

An oral pill for COVID-19? Molnupiravir shows promise

Performance-enhancing substance use is longitudinally associated with criminal offending

Comprehensive reference on the science, technology, and applications of postbiotics

Over-the-counter antacids may improve glucose levels in people with diabetes

Remdesivir caused dangerously low heart rate in COVID-19 patients

Many people with fibromyalgia substitute CBD for opioids and pain medications, finds study

Antidepressants taken during pregnancy do not increase risk for autism spectrum disorder

Researchers reanalyze COVID RECOVERY trial data on tocilizumab

Bivalent DNA SARS-CoV-2 vaccine induces strong humoral and cellular immunity in mice

Scientists use new technology to optimize drug development for brain diseases

Repurposing immunomodulatory drugs to treat COVID-19

Vaccine side effects should be viewed as a sign of efficacy, say immunologists

First spatial scan analysis helps identify hotspots of undervaccinated children

Statin use among heart failure patients can reduce cancer risk

mRNA COVID-19 vaccines may increase patients' concerns about side effects

Clinicians report cases of rare neurological disorder following COVID-19 vaccination

FDA approves oral pellets to treat children with venous thromboembolism

Effect of national tender system on the costs of biologic and targeted drugs in Norway

More research needed to clarify effects of cannabis on brain development of young adults with ADHD

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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