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Immunomodulatory drugs improve the success rate of cancer therapies

Immunomodulatory drugs, including the Contergan derivatives lenalidomide and pomalidomide, have significantly improved the therapy of hematologic malignancies such as multiple myeloma.

15 Feb 2021

Study: Aspirin should be favored to prevent blood clots in children after complex heart surgery

Aspirin should be favored over warfarin to prevent blood clotting in children who undergo a surgery that replumbs their hearts, according to a new study.

14 Feb 2021

Poor and terminally ill Mexicans have less chance to get opioids intended for palliative care

If you're poor and terminally ill in southern Mexico, there's far less chance you'll get the painkillers you need for palliative care than your cousins in more prosperous regions, particularly those pharmacy-rich areas along Mexico-U.S. border, say UCLA researchers and colleagues who studied opioid dispensing levels across the country.

13 Feb 2021

FDA approves drug to reduce frequency of chemotherapy-induced bone marrow suppression

Today, the U.S. Food and Drug Administration approved Cosela (trilaciclib) as the first therapy in its class to reduce the frequency of chemotherapy-induced bone marrow suppression in adults receiving certain types of chemotherapy for extensive-stage (when the cancer has spread beyond the lungs) small cell lung cancer.

13 Feb 2021

How effective has the COVID-19 vaccination program been in Israel?

Using publicly available coronavirus disease 2019 (COVID-19) data from Israel, a study suggests the BioNTech-Pfizer BNT162b2 vaccine is proving highly effective in the real world.

12 Feb 2021

People previously infected with COVID-19 respond strongly to one dose of Pfizer vaccine

Although clinical trial data are encouraging, real-world evidence with regard to the COVID-19 vaccine remains scarce. In particular, response to the vaccine among those previously infected with SARS-CoV-2 is still not completely understood.

12 Feb 2021

Opioid use during pregnancy can cause long-lasting impairment in the infant's brain

As the number of pregnant women using opioid drugs continues to rise, questions have been raised about the long-term health effects on children exposed to these drugs in the womb.

12 Feb 2021

New gut microbiome-based approach may have translational potential for cancer immunotherapy

Scientists from Nanjing University and the University of Macau have devised a new approach to extend the survival of transplanted probiotics in vivo, enhancing the efficacy of cancer chemo-/immunotherapies in mice.

11 Feb 2021

MD Anderson and Mirati Therapeutics collaborate to expand evaluation of potent KRAS inhibitors

The University of Texas MD Anderson Cancer Center and Mirati Therapeutics, Inc. today announced a strategic research and development collaboration to expand the evaluation of Mirati's two investigational small molecules, potent and selective KRAS inhibitors - adagrasib (MRTX849), a G12C inhibitor in clinical development, and MRTX1133, a G12D inhibitor in preclinical development, as monotherapy and in combination with other agents - which target two of the most frequent KRAS mutations in cancer.

10 Feb 2021

Orally administered experimental drug halts SARS-CoV-2 replication, prevents infection

Publishing their work in Nature, scientists at the UNC School of Medicine and UNC Gillings School of Global Public Health found that the orally administered experimental drug EIDD-2801 halts SARS-CoV-2 replication and prevents infection of human cells in a new in vivo lab model containing human lung tissue.

10 Feb 2021

New method of producing drug candidates may lead to better medicines in the future

A lot of our medicines and other bioactive drugs are based on chemical structures called "enantiomers"-- molecules that are mirror images of each other and are non-superimposable. Notable among them are chiral N,N-acetals contained in diuretic drugs like bendroflumethiazide and thiabutazide, used to treat high blood pressure and edema.

10 Feb 2021

FDA issues EUA for bamlanivimab and etesevimab for COVID-19 treatment

Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for bamlanivimab and etesevimab administered together for the treatment of mild to moderate COVID-19 in adults and pediatric patients (12 years of age or older weighing at least 40 kilograms [about 88 pounds]) who test positive for SARS-CoV-2 and who are at high risk for progressing to severe COVID-19.

10 Feb 2021

Acceptance of COVID-19 vaccine has increased significantly under Biden administration

Under the Biden Administration, New Yorkers' acceptance of the Covid-19 vaccine has increased significantly. In September, 55% of residents reported they would take the vaccine when it became available and this January, 64% reported they would take it.

9 Feb 2021

COVID-19 vaccination associated with 3- to 5-fold reduction in viral load

Researchers in Israel report a reduction in viral load in vaccinated individuals.

9 Feb 2021

Inhibition of protein glycosylation successfully prevents SARS-CoV-2 infection in vitro

A new study provides direct evidence that the oligosaccharides attached to the viral surface spike protein are essential for viral infection, offering new approaches to preventive and therapeutic drugs.

9 Feb 2021

Commentary on severe allergic reaction to mRNA SARS-CoV-2 vaccines

A commentary by John M. Kelso, Division of Allergy, Asthma and Immunology, Scripps Clinic, published in the latest issue of the journal Vaccines, discusses anaphylactic reactions to these novel mRNA SARS-CoV-2/COVID-19 vaccines.

8 Feb 2021

$FDA approves cell-based gene therapy to treat adults with relapsed or refractory large-B-cell lymphoma$

FDA approves cell-based gene therapy to treat adults with relapsed or refractory large-B-cell lymphoma

Today, the U.S. Food and Drug Administration approved Breyanzi (lisocabtagene maraleucel), a cell-based gene therapy to treat adult patients with certain types of large B-cell lymphoma who have not responded to, or who have relapsed after, at least two other types of systemic treatment.

5 Feb 2021

SGD Pharma Takes Lead in Sustainability, Awarded Platinum EcoVadis Rating for The First Time

SGD Pharma, a leading supplier of glass primary packaging in the pharmaceutical industry, has been awarded a ‘platinum’ rating by EcoVadis, positioning it in the top 1% of all companies rated worldwide.

From SGD Pharma 5 Feb 2021

FDA schedules meeting to discuss EUA request for Janssen’s COVID-19 vaccine

The U.S. Food and Drug Administration has scheduled a meeting of its Vaccines and Related Biological Products Advisory Committee (VRBPAC) on Feb. 26, 2021, to discuss the request for emergency use authorization (EUA) for a COVID-19 vaccine from Janssen Biotech Inc.

5 Feb 2021

Study calls for continuous monitoring of dark web marketplaces in view of vaccines shortage

New research carried out by City data scientist, Dr. Andrea Baronchelli, and colleagues, into the dark web marketplace (DWM) trade in products related to COVID-19, has revealed the need for the continuous monitoring of dark web marketplaces (DWMs), especially in light of the current shortage and availability of coronavirus vaccines.

5 Feb 2021

Pharmaceutical News

Immunomodulatory drugs improve the success rate of cancer therapies

Study: Aspirin should be favored to prevent blood clots in children after complex heart surgery

Poor and terminally ill Mexicans have less chance to get opioids intended for palliative care

FDA approves drug to reduce frequency of chemotherapy-induced bone marrow suppression

How effective has the COVID-19 vaccination program been in Israel?

People previously infected with COVID-19 respond strongly to one dose of Pfizer vaccine

Opioid use during pregnancy can cause long-lasting impairment in the infant's brain

New gut microbiome-based approach may have translational potential for cancer immunotherapy

MD Anderson and Mirati Therapeutics collaborate to expand evaluation of potent KRAS inhibitors

Orally administered experimental drug halts SARS-CoV-2 replication, prevents infection

New method of producing drug candidates may lead to better medicines in the future

FDA issues EUA for bamlanivimab and etesevimab for COVID-19 treatment

Acceptance of COVID-19 vaccine has increased significantly under Biden administration

COVID-19 vaccination associated with 3- to 5-fold reduction in viral load

Inhibition of protein glycosylation successfully prevents SARS-CoV-2 infection in vitro

Commentary on severe allergic reaction to mRNA SARS-CoV-2 vaccines

FDA approves cell-based gene therapy to treat adults with relapsed or refractory large-B-cell lymphoma

SGD Pharma Takes Lead in Sustainability, Awarded Platinum EcoVadis Rating for The First Time

FDA schedules meeting to discuss EUA request for Janssen’s COVID-19 vaccine

Study calls for continuous monitoring of dark web marketplaces in view of vaccines shortage

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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