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Novel vaccination strategy shows promise in boosting immunity and controlling influenza spread in pigs

Study demonstrates that a novel prime/boost vaccination protocol using live-attenuated influenza vaccines effectively induces strong immune responses in pigs, offering a promising approach for future influenza vaccination strategies.

13 Aug 2024

Dopaminergic drug levodopa linked to better sleep in Parkinson’s patients

A study involving 22 Parkinson's disease (PD) patients has shown that use of the dopaminergic drug levodopa improves sleep quality.

13 Aug 2024

New insights into the pharmacokinetics of remdesivir in treating SARS-CoV-2 in pregnant women

A new study provides important insights into the pharmacokinetics and safety of intravenous remdesivir in treating the SARS-CoV-2 coronavirus in pregnant women.

13 Aug 2024

AlphaFold accelerates discovery of potential antipsychotic drugs by outperforming traditional methods

Researchers used AlphaFold and homology modeling to identify potent TAAR1 agonists, showing AlphaFold's superior performance in drug discovery for neuropsychiatric conditions.

13 Aug 2024

Common antibiotics linked to severe skin reactions, study warns doctors to choose wisely

Research reveals that sulfonamides and cephalosporins significantly increase the risk of serious cutaneous adverse drug reactions, highlighting the importance of careful antibiotic selection in elderly patients.

12 Aug 2024

Childhood vaccinations save trillions in societal costs while preventing millions of illnesses and deaths

Routine childhood vaccinations among children born between 1994 and 2023 have prevented millions of illnesses and deaths in the U.S., saving $540 billion in direct costs and $2.7 trillion in societal costs.

12 Aug 2024

ATP regulation in ClC-3 exchangers linked to neurodegenerative diseases, study reveals

Researchers structurally analyzed adenine nucleotide control and neurodegenerative diseases in ClC-3 exchangers.

11 Aug 2024

Common oral antibiotics tied to increased risk of severe drug-induced rashes

Two classes of commonly prescribed oral antibiotics are associated with the greatest risk for severe drug rashes that can lead to emergency department visits, hospitalizations and even death, according to a new study.

8 Aug 2024

Insilico Medicine's pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven biotechnology company, today announced ISM6331, potential best-in-class pan-TEAD inhibitor, has received the U.S. Food and Drug Administration (FDA) Investigational New Drug (IND) clearance for the treatment of mesothelioma, following the grant of Orphan Drug Designation (ODD) in June 2024. It brings the total number of IND-approved molecules of Insilico to nine.

8 Aug 2024

Review reveals high rates of opioid dependence among chronic pain patients

A new scientific review of 148 studies enrolling over 4.3 million adult chronic pain patients treated with prescription opioid painkillers has found that nearly one in ten patients experiences opioid dependence or opioid use disorder and nearly one in three shows symptoms of dependence and opioid use disorder.

8 Aug 2024

How little Denmark got homegrown giant Novo Nordisk to lower ozempic prices

On May 13, Sen. Bernie Sanders (I-Vt.) published an open letter to Novo Nordisk on the front page of a leading Danish newspaper, urging the hometown company to live up to its altruistic standards by lowering U.S. prices for its blockbuster diabetes and weight loss drugs.

8 Aug 2024

Amyloid immunotherapy for early Alzheimer's: Promising but fraught with challenges

Researchers highlighted the complexities of using amyloid immunotherapy for early Alzheimer's disease, discussing its clinical benefits, challenges, and broader health implications. Despite some positive results, concerns over adverse effects, trial biases, and cost hinder widespread adoption.

7 Aug 2024

Recombinant shingles vaccine linked to lower dementia risk, especially in women

Study published in Nature Medicine found that the recombinant shingles vaccine is linked to a reduced risk of dementia. This protective effect was particularly notable in females, suggesting a potential advantage of the recombinant vaccine over the live vaccine.

7 Aug 2024

From discovery to approval: Vorasidenib approved by FDA for treatment of IDH-mutant gliomas

A new drug for treatment of a type of brain cancer, called IDH-mutant low-grade glioma, was approved Aug. 6 by the U.S. Food and Drug Administration (FDA).

7 Aug 2024

FDA approves vorasidenib for Grade 2 gliomas with IDH mutations

Vorasidenib has been approved by the U.S. Food and Drug Administration (FDA) for patients with Grade 2 gliomas with IDH1 or IDH2 mutations.

6 Aug 2024

Cambridge experts question efficacy and practicality of new amyloid immunotherapy drugs

Cambridge researchers have cast doubt on whether new amyloid immunotherapy drugs will have the desired effect of significantly reducing the impact of Alzheimer's disease.

6 Aug 2024

Enhancing nitrofurantoin solubility and bioavailability through solid dispersion formulation

Announcing a new article publication for BIO Integration journal. Nitrofurantoin is a BCS II drug with a low solubility and dissolution rate.

6 Aug 2024

Valproic acid shows promise in reducing COVID-19 severity and hospitalization

Researchers found that valproic acid (VPA), especially when combined with DHA, significantly reduces SARS-CoV-2 infection rates and severity, potentially activating antiviral mechanisms. Epidemiologic data support VPA's role in reducing COVID-19 severity and hospitalization rates.

6 Aug 2024

Study confirms cardiovascular safety of COVID-19 vaccines among millions of adults in England

A study confirms the cardiovascular safety of different COVID-19 vaccine doses, showing reduced risks of common cardiovascular events among vaccinated adults in England.

4 Aug 2024

Public insurance recipients less likely to receive diabetes and obesity drug, study reveals

A new USC study suggests that publicly insured individuals who are most likely to benefit from new drugs for diabetes and obesity are less likely to get them than those with private insurance.

2 Aug 2024

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Pharmaceutical News

Novel vaccination strategy shows promise in boosting immunity and controlling influenza spread in pigs

Dopaminergic drug levodopa linked to better sleep in Parkinson’s patients

New insights into the pharmacokinetics of remdesivir in treating SARS-CoV-2 in pregnant women

AlphaFold accelerates discovery of potential antipsychotic drugs by outperforming traditional methods

Common antibiotics linked to severe skin reactions, study warns doctors to choose wisely

Childhood vaccinations save trillions in societal costs while preventing millions of illnesses and deaths

ATP regulation in ClC-3 exchangers linked to neurodegenerative diseases, study reveals

Common oral antibiotics tied to increased risk of severe drug-induced rashes

Insilico Medicine's pan-TEAD inhibitor ISM6331 receives FDA IND clearance for mesothelioma treatment

Review reveals high rates of opioid dependence among chronic pain patients

How little Denmark got homegrown giant Novo Nordisk to lower ozempic prices

Amyloid immunotherapy for early Alzheimer's: Promising but fraught with challenges

Recombinant shingles vaccine linked to lower dementia risk, especially in women

From discovery to approval: Vorasidenib approved by FDA for treatment of IDH-mutant gliomas

FDA approves vorasidenib for Grade 2 gliomas with IDH mutations

Cambridge experts question efficacy and practicality of new amyloid immunotherapy drugs

Enhancing nitrofurantoin solubility and bioavailability through solid dispersion formulation

Valproic acid shows promise in reducing COVID-19 severity and hospitalization

Study confirms cardiovascular safety of COVID-19 vaccines among millions of adults in England

Public insurance recipients less likely to receive diabetes and obesity drug, study reveals

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