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Antibiotics no longer effective in treating childhood infections in large parts of the world

Drugs to treat common infections in children and babies are no longer effective in large parts of the world, due to high rates of antibiotic resistance.

31 Oct 2023

Day-to-day painkiller use doesn't lower empathy levels, but misuse might, according to recent survey

The association between low empathy and prosocial behavior on the one hand and analgesic consumption.

30 Oct 2023

Stopping metformin early linked to higher dementia risk in older adults with type 2 diabetes

Early termination of metformin treatment in older adults with type 2 diabetes is associated with a higher risk of dementia, according to a cohort study. The research has significant implications for diabetes management, especially among those at higher risk for dementia.

29 Oct 2023

New study highlights risks of anti-ERBB2 cancer drugs during pregnancy

Study finds that anti-ERBB2 inhibitors used in breast cancer treatment pose significant risks to pregnancy and fetal health, including higher likelihoods of congenital defects and intrauterine growth restriction. Researchers recommend careful monitoring and possibly discontinuing these drugs during pregnancy despite their effectiveness against cancer.

29 Oct 2023

MHRA grants conditional marketing authorization for AbbVie's Tepkinly to treat aggressive blood cancer

AbbVie today announced that the UK Medicines and Healthcare products Regulatory Agency has granted conditional Marketing Authorisation for Tepkinly® (epcoritamab) as a monotherapy for the treatment of adults with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL), after two or more systemic therapies.

28 Oct 2023

Low-cost anti-inflammatory hydrogel could help treat chronic skin lesions in people with diabetes

Researchers in São Paulo state, Brazil, have developed a low-cost anti-inflammatory hydrogel that in future could help treat chronic skin lesions such as those often seen in people with diabetes.

27 Oct 2023

FDA approves a new steroidal-type anti-inflammatory drug for Duchenne muscular dystrophy

Boys with Duchenne muscular dystrophy (DMD) have a clinically proven, new treatment option with the Food and Drug Administration's approval Thursday of vamorolone, a steroidal-type, anti-inflammatory drug developed based on research performed at Children's National Hospital.

27 Oct 2023

AI-designed drug candidate shows promise for gastric acid inhibition

Researchers at Nagoya University in Japan created and improved artificial intelligence (AI) designs to synthesize a candidate compound for a new gastric acid inhibitor with a better binding affinity than existing drugs.

26 Oct 2023

Study finds link between industry payments to oncologists and non-recommended cancer treatments

Patients with cancer whose oncologist receives payments from industry appear more likely to receive some non-recommended and low value treatments, finds a US study published by The BMJ today.

25 Oct 2023

NF-κB activation during COVID-19 and its impact on patients with hypertension

Researchers review the role of NF-κB activation in the replication of SARS-CoV-2 and the impact of COVID-19 medications on NF-κB activation.

25 Oct 2023

Scientists achieve breakthrough in treating 'neglected' polymyalgia rheumatica

Scientists have found success in treating a 'neglected' inflammatory condition, polymyalgia rheumatica, with a drug that could provide an alternative to steroids for patients.

25 Oct 2023

Lack of direct comparisons prevents assessment of upadacitinib's benefit in Crohn's disease

Like several immunosuppressive biologics, the JAK inhibitor upadacitinib is also approved for the treatment of Crohn's disease. Commissioned by the Federal Joint Committee (G-BA), the Institute for Quality and Efficiency in Health Care (IQWiG) has now investigated in an early benefit assessment whether the drug offers an added benefit versus the appropriate comparator therapy to patients with moderate to severe active Crohn's disease who have had an inadequate response, lost response or are intolerant to conventional therapy or a biologic agent.

25 Oct 2023

Viral rebound common in lung transplant recipients treated with nirmatrelvir/ritonavir for COVID-19

Data on the viral rebound and safety of nirmatrelvir/ritonavir in lung transplant (LTx) recipients are limited.

24 Oct 2023

Study identifies predictors of opioid overdose after prescription for chronic pain

A large study published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.230459 identified 10 predictors of opioid overdose after prescription for chronic pain, which can help clinicians engage in shared decision-making with patients around opioid prescribing.

24 Oct 2023

University of Montana awarded $12.3 million contract to develop novel vaccine adjuvant for TB vaccine

The National Institutes of Health recently awarded a $12.3 million contract to the University of Montana to develop a novel vaccine adjuvant for use in a tuberculosis vaccine. Adjuvants are substances that boost the effectiveness of vaccines.

24 Oct 2023

Groundbreaking study reveals most effective adjunctive drug for Parkinson's disease

The efficacy, tolerability, and safety of various anti-Parkinson's drugs.

23 Oct 2023

Ketamine's long-lasting antidepressant effects unveiled in new study

Persistent blocking of NMDAR and burst-type firing by lateral habenula (LHb) neurons may offer a basis for the long-lasting antidepressant effects of ketamine.

22 Oct 2023

Novel GLP-1 receptor agonists offer hope for long-lasting diabetes treatment

In a study published in Scientific Reports, researchers engineer long-lasting GLP-1 receptor agonists by fusing GLP-1 with an HSA-binding protein. These chimeric molecules show promise for the treatment of type 2 diabetes due to their stability, functionality, and high affinity for the GLP-1 receptor and human serum albumin.

22 Oct 2023

How ketamine treatment elicits long-lasting anti-depressive effects

Researchers discuss the mechanisms responsible for the sustained antidepressant effects of ketamine by examining ketamine-NMDAR interactions.

20 Oct 2023

Steroid use linked to increased concussion risk in high school athletes

Higher body mass index and increased aggression caused by steroid use could increase the potential for sustaining a concussion, researchers say.

19 Oct 2023

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Pharmaceutical News

Antibiotics no longer effective in treating childhood infections in large parts of the world

Day-to-day painkiller use doesn't lower empathy levels, but misuse might, according to recent survey

Stopping metformin early linked to higher dementia risk in older adults with type 2 diabetes

New study highlights risks of anti-ERBB2 cancer drugs during pregnancy

MHRA grants conditional marketing authorization for AbbVie's Tepkinly to treat aggressive blood cancer

Low-cost anti-inflammatory hydrogel could help treat chronic skin lesions in people with diabetes

FDA approves a new steroidal-type anti-inflammatory drug for Duchenne muscular dystrophy

AI-designed drug candidate shows promise for gastric acid inhibition

Study finds link between industry payments to oncologists and non-recommended cancer treatments

NF-κB activation during COVID-19 and its impact on patients with hypertension

Scientists achieve breakthrough in treating 'neglected' polymyalgia rheumatica

Lack of direct comparisons prevents assessment of upadacitinib's benefit in Crohn's disease

Viral rebound common in lung transplant recipients treated with nirmatrelvir/ritonavir for COVID-19

Study identifies predictors of opioid overdose after prescription for chronic pain

University of Montana awarded $12.3 million contract to develop novel vaccine adjuvant for TB vaccine

Groundbreaking study reveals most effective adjunctive drug for Parkinson's disease

Ketamine's long-lasting antidepressant effects unveiled in new study

Novel GLP-1 receptor agonists offer hope for long-lasting diabetes treatment

How ketamine treatment elicits long-lasting anti-depressive effects

Steroid use linked to increased concussion risk in high school athletes

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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