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GLP-1 weight loss drugs linked to heightened GI risks, says new study

Study from JAMA reveals that users of GLP-1 agonists, recent drugs for weight management, show a heightened risk of gastrointestinal complications like intestinal obstruction, gastroparesis, and pancreatitis. Though these effects are rare, those considering these drugs for weight loss should weigh the benefits against potential risks, especially if not using them for diabetes.

5 Oct 2023

GLP-1 agonists linked to higher risk for gastrointestinal complications

They're being hailed as an effective way to lose weight, but diabetes drugs like Ozempic may come with a heightened risk of severe gastrointestinal problems.

5 Oct 2023

Can falsified or substandard antimicrobials increase antimicrobial resistance?

The association between substandard or falsified (SF) antibiotics and antimicrobial resistance (AMR).

5 Oct 2023

Esketamine nasal spray superior in achieving remission in patients with treatment-resistant depression

Both severe depression and treatment-resistant depression are common. Up to one third of patients do not respond to conventional therapy with antidepressants such as selective serotonin reuptake inhibitors (SSRIs) or serotonin-norepinephrine reuptake inhibitors (SNRIs).

5 Oct 2023

New drug tirzepatide equally effective in early-onset and later-onset type 2 diabetes

Tirzepatide is as effective at treating early-onset type 2 diabetes (T2D), a more aggressive form of the condition that normally responds less well to treatment, as it is at treating T2D diagnosed later in life, new research being presented at the Annual Meeting of the European Association for the Study of Diabetes (EASD) in Hamburg, Germany (2-6 Oct) has found.

4 Oct 2023

Prioritising Lung Health: How FeNO can help to tackle Lung Conditions, the UK's 3rd Largest Threat

A new report from PwC commissioned by Asthma+Lung UK has highlighted the alarming crisis surrounding Lung Health in the UK.

From NObreath 4 Oct 2023

Octopus-inspired suction patch revolutionizes drug delivery, promising an injection-free future

Scientists develop an octopus sucker-inspired buccal mucosa suction patch, enhancing systemic absorption of macromolecular drugs. This innovative, non-invasive delivery platform, validated on porcine and human subjects, presents a potential alternative to intravenous injections for better drug bioavailability and patient compliance.

4 Oct 2023

Antiviral treatment emerges as a potential game-changer in curbing type 1 diabetes progression

New research from the University of Oslo reveals antiviral drugs could help preserve insulin production in children newly diagnosed with type 1 diabetes, potentially slowing down or even preventing the disease. The study, building on earlier findings linking enterovirus to type 1 diabetes, showed that antiviral treatment led to maintained insulin production, proposing a new therapeutic avenue to treat and mitigate the progression of type 1 diabetes.

3 Oct 2023

Mogrify extends Series A financing to $46 million USD

Mogrify Limited (Mogrify®), a biopharmaceutical company transforming the lives of patients through a novel class of in vivo reprogramming therapies, announced today an additional $10 million USD closing of its Series A financing.

From Mogrify 2 Oct 2023

Optibrium releases powerful metabolism prediction capability in next generation StarDrop software

Optibrium, a leading developer of software and AI solutions for drug discovery, today launched the latest version of its drug discovery platform, StarDrop.

From Optibrium Ltd. 2 Oct 2023

Maternal COVID-19 shots significantly lowered infant hospitalizations during Omicron wave

Study found that maternal COVID-19 vaccination during pregnancy significantly reduces the risk of COVID-19-related hospitalizations in infants under six months, particularly boosting protection during the first three months of life. With 78% of the hospitalized infants born to unvaccinated mothers, the research emphasizes the crucial role of maternal vaccination in safeguarding infants too young for vaccination.

2 Oct 2023

Extending FDA-approved cancer drug indications requires high patient numbers, study finds

Number of patient participants needed for secondary approval of a new cancer drug.

29 Sep 2023

Aerosolized ACE2 neutralizes COVID-19 variants in lab and mice tests

Researchers from the University of Texas Southwestern have developed an aerosolized, mutated form of ACE2 that effectively neutralizes various SARS-CoV-2 variants in both cell cultures and mice. The study suggests that this modified ACE2 has promising preventive and therapeutic potential against COVID-19, especially with its easy aerosolized administration.

28 Sep 2023

Vaxzevria vaccine boosts mucosal immunity in COVID-19 recovered

Study highlights the ability of the Vaxzevria vaccine in inducing robust mucosal antibody responses, especially in COVID-19-recovered individuals, showcasing a notable defense against various SARS-CoV-2 variants. However, it emphasizes the need for booster doses to enhance anti-SARS-CoV-2 mucosal immunity, especially in infection-naïve individuals, to broaden protection against emerging viral variants.

28 Sep 2023

Commonly used anti-viral drugs reduce risk of hospitalization, death in patients with mild COVID-19

New Cleveland Clinic-led research shows commonly used COVID-19 anti-viral drugs Paxlovid (nirmatrelvir) and Lagevrio (molnupiravir) reduce risk of hospitalization and death in high-risk patients with mild disease, even with Omicron subvariants.

28 Sep 2023

How does taking a pause on the oral contraceptive pill impact mental health?

Users of combination oral contraceptive agents experience one time per month (pill break) was connected with mood changes.

28 Sep 2023

Could next-generation antimicrobial agents act as an alternative to standard antibiotics?

Next-generation antimicrobial agents (NGAs) as a potential alternative to standard antibiotics

26 Sep 2023

One health wake-up call: London's river data highlights environmental perils

The largest-ever spatiotemporal monitoring of chemicals/contaminants of emerging concern (CECs) in London waterways.

26 Sep 2023

Monkeypox mimics smallpox vaccine's immune response, new study reveals

The study in Nature Communications reveals that MPOX infection triggers an anti-viral antibody response akin to that from smallpox vaccination. Utilizing a comprehensive array of ELISAs, scientists found a high level of specificity and sensitivity in detecting antibodies against both MPOX and smallpox, offering a new, accurate way to measure immune responses.

26 Sep 2023

Intranasal vaccine shows promise against COVID variants in hamsters

Intranasal mRNA-LNP vaccines show promise in Syrian golden hamsters, effectively reducing SARS-CoV-2 viral loads and lung pathology. The study suggests potential efficacy against new variants, setting the stage for future research in human applications.

25 Sep 2023

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Pharmaceutical News

GLP-1 weight loss drugs linked to heightened GI risks, says new study

GLP-1 agonists linked to higher risk for gastrointestinal complications

Can falsified or substandard antimicrobials increase antimicrobial resistance?

Esketamine nasal spray superior in achieving remission in patients with treatment-resistant depression

New drug tirzepatide equally effective in early-onset and later-onset type 2 diabetes

Prioritising Lung Health: How FeNO can help to tackle Lung Conditions, the UK's 3rd Largest Threat

Octopus-inspired suction patch revolutionizes drug delivery, promising an injection-free future

Antiviral treatment emerges as a potential game-changer in curbing type 1 diabetes progression

Mogrify extends Series A financing to $46 million USD

Optibrium releases powerful metabolism prediction capability in next generation StarDrop software

Maternal COVID-19 shots significantly lowered infant hospitalizations during Omicron wave

Extending FDA-approved cancer drug indications requires high patient numbers, study finds

Aerosolized ACE2 neutralizes COVID-19 variants in lab and mice tests

Vaxzevria vaccine boosts mucosal immunity in COVID-19 recovered

Commonly used anti-viral drugs reduce risk of hospitalization, death in patients with mild COVID-19

How does taking a pause on the oral contraceptive pill impact mental health?

Could next-generation antimicrobial agents act as an alternative to standard antibiotics?

One health wake-up call: London's river data highlights environmental perils

Monkeypox mimics smallpox vaccine's immune response, new study reveals

Intranasal vaccine shows promise against COVID variants in hamsters

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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