Huntington's Disease News and Research

Latest Huntington's Disease News and Research

New CRISPR technology may help eliminate mutated gene sequence

In a new study in cells, University of Illinois researchers have adapted CRISPR gene-editing technology to cause the cell's internal machinery to skip over a small portion of a gene when transcribing it into a template for protein building.

17 Aug 2018

OHSU researchers discover disease in monkeys that mimics childhood neurodegenerative disorder

OHSU scientists have discovered a naturally occurring disease in monkeys that mimics a deadly childhood neurodegenerative disorder in people - a finding that holds promise for developing new gene therapies to treat Batten disease.

27 Jul 2018

Scientists use new drug discovery system to target Huntington’s Disease

Scientists have used a new drug discovery system to specifically target phosphatases in Huntington's, which were previously thought to be undruggable.

27 Jul 2018

Scientists use new drug discovery system to target Huntington’s Disease

Scientists have used a new drug discovery system to specifically target phosphatases in Huntington's, which were previously thought to be undruggable.

27 Jul 2018

New drug discovery system allows scientists to target ‘undruggable’ enzymes

A new drug discovery system allows scientists to specifically target members of an important family of enzymes, called phosphatases, which were previously considered mostly "undruggable".

27 Jul 2018

Scientists take important step to understand mechanisms that cause Huntington's disease

The neuroscientist Dr David Vilchez and his team at CECAD, the University of Cologne's Cluster of Excellence for Aging Research, have made an important step towards understanding the mechanisms that cause the neurodegenerative disorder Huntington's disease.

27 Jul 2018

Researchers investigate recessive genetic disorder that leads to childhood blindness

Our genome is made up of 20,000 genes, all of which may cause disease. At present, 4,141 genes have been identified as being responsible for genetic abnormalities, leaving around 16,000 genes with unknown implication in disease.

23 Jul 2018

New theory on Huntington's disease shows promise to open new avenues of drug development

McMaster University researchers have developed a new theory on Huntington's disease which is being welcomed for showing promise to open new avenues of drug development for the condition.

10 Jul 2018

Single-cell RNA sequencing reveals how complex brain circuit works

The complexity of the human brain presents scientists with immense challenges as they try to find new treatments for a host of diseases and conditions. But the advent of a new technology known as single-cell RNA sequencing is opening a window into how the brain works.

6 Jul 2018

CRISPR technique reduces repetitive behavior in fragile X syndrome mouse models

Scientists have used CRISPR-Cas9 gene editing to lessen some autism symptoms in mice with a form of fragile X syndrome, the most common known single-gene cause of autism spectrum disorder.

25 Jun 2018

Researchers use gene editing to reduce autism symptoms in mice

Researchers have used CRISPR-Cas9 gene editing to treat symptoms of autism in mice. It is hoped that the tool could one day be used to help humans.

25 Jun 2018

Researchers outline a connection between subplate neurons and brain disorders

The disappearance of an entire brain region should be cause for concern. Yet, for decades scientists have calmly maintained that one brain area, the subplate, simply vanishes during the course of human development.

22 Jun 2018

Study unravels new piece of information in the Huntington’s disease puzzle

In a new study, researchers from the University of Copenhagen have discovered a hitherto unknown error in the transport of glutamine between astrocytes and neurons in the brain of mice with Huntington's disease.

21 Jun 2018

Study unravels how nuclear pore complexes transport mRNAs out of the nucleus

Standing guard between a cell's nucleus and its main chamber, called the cytoplasm, are thousands of behemoth protein structures called nuclear pore complexes, or NPCs.

13 Jun 2018

Scientists find overlap between causes of RA and Huntington’s disease

Using new analytic tools, researchers at University of California San Diego School of Medicine and the Icahn School of Medicine at Mount Sinai have decoded the epigenetic landscape for rheumatoid arthritis (RA), a common autoimmune disease that affects more than 1.3 million Americans.

15 May 2018

CRISPR-based treatment can restore retinal function in mice with eye disease

Researchers from Columbia University have developed a new technique for the powerful gene editing tool CRISPR to restore retinal function in mice afflicted by a degenerative retinal disease, retinitis pigmentosa.

11 May 2018

Salk researchers clarify relationship of two neuron types to psychiatric and movement disorders

If 95 percent of your neighbors are chatty and outgoing, you probably know more about them than the 5 percent who are reclusive and shy.

3 May 2018

Key signaling protein in Huntington's disease found to have deleterious effects on heart function, shows study

Researchers investigating a key signaling protein in Huntington's disease describe deleterious effects on heart function, going beyond the disease's devastating neurological impact.

25 Apr 2018

Higher consumption of fish linked to better neurological health

A new study from Chalmers University of Technology, Sweden, shines more light on the link between consumption of fish and better long-term neurological health.

23 Apr 2018

Scientists use CRISPR tool to make multiple edits to DNA samples 'in vitro'

Scientists at Christiana Care Health System's Gene Editing Institute have developed a potentially breakthrough CRISPR gene-editing tool. It could allow researchers to take fragments of DNA extracted from human cells, put them into a test tube, and quickly and precisely engineer multiple changes to the genetic code, according to a new study published today in the CRISPR Journal.

20 Apr 2018