Pharmacology News and Research

Latest Pharmacology News and Research

Researchers identify long-sought enzyme that prevents cancer

Researchers have found a long-sought enzyme that prevents cancer by enabling the breakdown of proteins that drive cell growth, and that causes cancer when disabled.

14 Apr 2021

Biology of single-celled organisms reveals potential treatment target for COPD

In a series of experiments that began with amoebas -- single-celled organisms that extend podlike appendages to move around -- Johns Hopkins Medicine scientists say they have identified a genetic pathway that could be activated to help sweep out mucus from the lungs of people with chronic obstructive pulmonary disease a widespread lung ailment.

13 Apr 2021

Research could lead to better treatment for aggressive prostate cancer

New research from CU Cancer Center member Scott Cramer, PhD, and his colleagues could help in the treatment of men with certain aggressive types of prostate cancer.

12 Apr 2021

Toward a transformative therapy for sickle cell patients

For the millions of people worldwide who have sickle cell disease, there are only a few treatment options, which include risky bone marrow transplants, gene therapy or other treatments that address a subset of symptoms.

9 Apr 2021

Novel PF74 molecule effectively targets HIV capsid protein

Of all known small molecules targeting human immunodeficiency virus (HIV) capsid protein (CA), PF74 represents by far the best characterized chemotype, due to its ability to confer antiviral phenotypes in both early and late phases of viral replication.

9 Apr 2021

Novel diarylamides show promise as orally active diuretics to treat hyponatremia

Urea transporters (UT) play a vital role in the mechanism of urine concentration and are recognized as novel targets for the development of salt-sparing diuretics. Thus, UT inhibitors are promising for development as novel diuretics.

8 Apr 2021

Research offers an efficient approach to mine the chemical diversity of endophytic fungi

Endophytic fungi are promising producers of bioactive small molecules. Bioinformatic analysis of the genome of an endophytic fungus Penicillium dangeardii revealed 43 biosynthetic gene clusters, exhibited its strong ability to produce numbers of secondary metabolites.

8 Apr 2021

Acrylamide-based novel DHODH inhibitors as potential treatment for rheumatoid arthritis

Human dihydroorotate dehydrogenase (DHODH) is a viable target for the development of therapeutics to treat cancer and immunological diseases, such as rheumatoid arthritis (RA), psoriasis and multiple sclerosis (MS).

8 Apr 2021

Acrylamide-based DHODH inhibitors are potential agents for treating rheumatoid arthritis

Human dihydroorotate dehydrogenase(DHODH) is a viable target for the development of therapeutics to treat cancer andimmunological diseases, such asrheumatoid arthritis(RA), psoriasis andmultiple sclerosis(MS).

8 Apr 2021

Antifungal and antidepressant drugs can effectively inhibit COVID-19 virus

New research published in the British Journal of Pharmacology indicates that two currently available medications--an antifungal drug and an antidepressant--can effectively inhibit the virus that causes COVID-19 in laboratory cells.

7 Apr 2021

UCI receives $4.2 million grant to study sporadic inclusion body myositis affecting aging adults

The National Institute of Arthritis and Musculoskeletal and Skin Diseases has awarded UCI a 5-year, $4.2 million grant to study sporadic inclusion body myositis (sIBM), which affects aging adults causing asymmetric muscle weakness and severe disability. The disease is currently untreatable and poorly understood.

6 Apr 2021

Mother's stress levels during conception could be a determinant of fetal sex

A study carried out by scientists from the University of Granada has revealed that women who experience stress both before becoming pregnant and during conception are almost twice as likely to have a girl as a boy.

6 Apr 2021

Researchers define genetic landscape of uterine leiomyosarcomas

In a new study, Yale Cancer Center researchers have defined the genetic landscape of uterine leiomyosarcomas (uLMS).

6 Apr 2021

Temple, Case Western scientists receive $3 million NIH grant to study pathway behind heart failure

Like a bad water pump that fails to circulate coolant in a car engine, a failing heart struggles to pump blood through the body, causing symptoms of fatigue, shortness of breath, and swelling in the legs and feet.

5 Apr 2021

Massive X-ray screening identifies several candidates for drugs against novel coronavirus

A team of researchers has identified several candidates for drugs against the coronavirus SARS-CoV-2 at DESY´s high-brilliance X-ray lightsource PETRA III.

3 Apr 2021

UCI-led team to address health impacts of adverse childhood experiences using precision medicine

A collaborative team centered in the University of California, Irvine and including Children's Hospital Orange County and Chapman University has been awarded a three-year grant totaling in excess of $2.3 million, to address the health impacts of adverse childhood experiences using precision medicine.

1 Apr 2021

Study sheds new light on the role of oxygen deprivation in cancer development

A team of University of Colorado School of Medicine researchers recently published a paper offering new insight into the role that oxygen deprivation, or hypoxia, plays in cancer development.

1 Apr 2021

New study may lead to GRK5-based therapies to prevent heart failure

The human heart works under high demand, constantly pumping oxygen-rich blood through the body. When faced with disease, however, fulfilling this demand can become increasingly difficult and harmful.

31 Mar 2021

Diabetes drug appears to exploit vulnerability of AIDS-causing retrovirus HIV

A team led by scientists at the UNC School of Medicine discovered an important vulnerability of the AIDS-causing retrovirus HIV, and has shown in preclinical experiments that a widely used diabetes drug, metformin, seems able to exploit this vulnerability.

29 Mar 2021

Study: Common medications are often derived from animal byproducts

More physicians and pharmacists are advocating for patients to be made aware of animal byproducts contained in common medications, according to new research in the Journal of Osteopathic Medicine.

29 Mar 2021