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How does penicillin work?

In this interview, we spoke to Dr. Bartlomiej Salamaga about his latest research that discovered how penicillin works in the body.

24 Nov 2021

Bat coronavirus ecology, evolution, and spillover

In a review published in Nature Reviews Microbiology, the authors collate information about the ecology and evolution of bat coronaviruses.

24 Nov 2021

Markers of SARS-CoV-2 shedding in vaccinated and unvaccinated individuals

The study uses serial mid-turbinate nasal specimens collected from a subset of incarcerated persons infected during this outbreak.

24 Nov 2021

Spread and evolution of SARS-CoV-2 lineages with possible recombination events

Researchers examined the dissemination and evolution of four SARS-CoV-2 lineages as well as the potential that one or more recombination events played a role in their evolution.

24 Nov 2021

Estimation of the SARS-CoV-2 infectious period

A new study focused on estimating the temporal dynamics of transmissibility of infected cases in the absence of intervention measures (unmitigated generation interval).

24 Nov 2021

Relaxation of COVID-19 restrictions led to the reemergence of seasonal respiratory viruses in Houston

A Houston Methodist study showed a rapid return of seasonal respiratory viruses after COVID-19 restrictions were relaxed in Texas, demonstrating the effectiveness of masking, distancing and other precautionary measures at stopping the spread of many respiratory illnesses, not just COVID-19.

24 Nov 2021

Limited immune responses three months after Pfizer-BioNTech vaccination among elderly

In this study, published on the medRxiv* preprint server, the humoral response to SARS-CoV-2 was assessed before and after three months of administration of the BNT162b2 mRNA COVID-19 vaccination (Pfizer-BioNTech). In addition, elders' humoral responses were compared to those of a younger group, and a functional neutralization experiment against the Wuhan-Hu-1 (WH1) virus and the Delta variant was carried out.

23 Nov 2021

Vaccine-induced immune responses for SARS-CoV-2 in patients receiving anti-CD20 B-cell depleting therapies

A new study published on the medRxiv* preprint server analyzed the trajectories of anti-SARS-CoV-2 antibodies in patients from the RituxiVac study were compared to healthy volunteers. In addition, they investigated the immunogenicity of a third vaccine dose in previously non-responding patients.

23 Nov 2021

CDC study finds Pfizer-BioNTech COVID vaccine provides high protection against hospitalization in adolescents

New research from the Centers for Disease Control & Prevention (CDC) suggest vaccines are highly protective against severe acute respiratory coronavirus 2 (SARS-CoV-2). Two doses of the Pfizer-BioNTech vaccine showed a 93% effectiveness against hospitalization. The findings add to a previous clinical trial that found vaccinated adolescents with 100% protection against SARS-CoV-2 infections.

23 Nov 2021

Higher antibody level correlates with greater vaccine protection against COVID-19

By measuring antibodies against the SARS-CoV-2 spike protein in participants in a phase 3 trial of the Moderna COVID-19 vaccine, researchers found that the higher the antibody level, the greater the vaccine protection against COVID-19.

23 Nov 2021

Discovery of a broad-spectrum antiviral activity in self-assembling immunostimulatory duplex RNAs

A new study, published on the bioRxiv* preprint server, has discovered a class of new immunostimulatory RNAs while studying influenza infection-associated host genes in human lung epithelial cells using small interfering RNAs (siRNAs). Scientists revealed that these short duplex RNAs could induce type I and type III interferons (IFN-I/III) in a wide variety of cells.

23 Nov 2021

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

A new study, published on the bioRxiv* preprint server, has focused on public clonotypes, i.e., clones found in multiple individuals, for the development of a novel reverse epitope discovery technique. This technique holds greater potential for population-wide applications.

23 Nov 2021

Mouthwash containing an antiviral phthalocyanine derivative shortens hospitalizations due to COVID-19

In a study published in the journal Scientific Reports, a research group from Brazil showed how antiviral anionic phthalocyanine derivative used in a mouthwash protocol may not only reduce the symptoms of coronavirus disease (COVID-19), but also hamper the spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

23 Nov 2021

Anti-inflammatory drug used to treat gout does not reduce the risk of COVID-19 mortality

Colchicine, a cheap anti-inflammatory drug normally used to treat gout, doesn't lessen COVID-19 severity or stave off the risk of death from the infection in hospital patients, finds a pooled analysis of the available evidence, published in the open access journal RMD Open.

23 Nov 2021

Disease/Infection News

How does penicillin work?

Bat coronavirus ecology, evolution, and spillover

Markers of SARS-CoV-2 shedding in vaccinated and unvaccinated individuals

Spread and evolution of SARS-CoV-2 lineages with possible recombination events

Estimation of the SARS-CoV-2 infectious period

Relaxation of COVID-19 restrictions led to the reemergence of seasonal respiratory viruses in Houston

Limited immune responses three months after Pfizer-BioNTech vaccination among elderly

Vaccine-induced immune responses for SARS-CoV-2 in patients receiving anti-CD20 B-cell depleting therapies

CDC study finds Pfizer-BioNTech COVID vaccine provides high protection against hospitalization in adolescents

Higher antibody level correlates with greater vaccine protection against COVID-19

Discovery of a broad-spectrum antiviral activity in self-assembling immunostimulatory duplex RNAs

A novel reverse epitope discovery approach to characterize SARS-CoV-2 public CD4+ αβ T cell clonotypes

Mouthwash containing an antiviral phthalocyanine derivative shortens hospitalizations due to COVID-19

Anti-inflammatory drug used to treat gout does not reduce the risk of COVID-19 mortality

Time of starting antiretroviral therapy can influence tumor development In HIV patients

Oral Hsp90 inhibitor SNX-5422 interferes with replication machinery of SARS-CoV-2

Study shows risk of MIS-C post mRNA vaccination against COVID-19 in children with autoimmune complications

Strong antibody responses against harmless coronaviruses may protect against SARS-CoV-2

SARS-CoV-2 moves between permissive cells and non-permissive neuronal cells via tunneling nanotubes (TNT)

Two-meter COVID-19 rule is not a concrete measurement of safety, say researchers

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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