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High single-dose efficacy of Pfizer vaccine against SARS-CoV-2 in older adults

In British Columbia (BC), Canada, vaccination against coronavirus disease 2019 (COVID-19) began with the Pfizer/Moderna mRNA (messenger ribonucleic acid) vaccines began with nursing home residents and frontline healthcare workers. These are known to have a high protective efficacy of 92-93% after a single dose, but this data comes from younger and healthy adults, for the most part.

11 Jun 2021

New Astra-Zeneca B.1.351 vaccine AZD2816 strongly immunogenic against multiple SARS-CoV-2 variants of concern

A new study, released on the bioRxiv* preprint server, supports the efficacy of the wildtype ChAdOx1 nCoV-19 (AZD1222) vaccine against B.1.351, B.1.617.1 and B.1.617.2, while showing that a booster dose of vaccine based on the B.1.351 spike induces further increase in antibody titers.

11 Jun 2021

Has COVID-19 vaccine confidence dropped following the pause of Johnson & Johnson/Janssen?

A new study, which was conducted by Vishala Mishra and Joseph P. Dexter at Madras Medical College, Chennai, India, suggests that the infamous pause in the administration of the Johnson & Johnson (J&J)/Janssen COVID-19 vaccine, advised by the FDA, has left doubt about the veracity of vaccine safety claims. This is a development that may have engendered vaccine hesitancy in a segment of the population.

11 Jun 2021

Scientists detect delayed and reduced antibody responses after BioNTech/Pfizer COVID-19 vaccination in older adults

Researchers at the U.S. Centers for Disease Control and Prevention (CDC) detected delayed and reduced antibody and T cell responses after immunization with BNT162b2 or the Pfizer-BioNTech COVID-19 vaccine in older adults compared with healthcare workers in Germany.

11 Jun 2021

SARS-CoV-2 infection detected in a poodle living with a COVID-19 positive family

Researchers in Italy identified a case of reverse zoonosis wherein animals contract the virus from humans. The team detected SARS-CoV-2 in a healthy poodle living with four family members who had COVID-19.

11 Jun 2021

NCCN experts provide new guidance on COVID-19 vaccines for cancer patients

The National Comprehensive Cancer Network® (NCCN®) today announced the publication of new guidance on COVID-19 vaccines for people with cancer, intended to clear up confusion for patients and caregivers. The new four-page patient guide is based on the latest expert review of evolving evidence.

11 Jun 2021

HEPA air purifier can significantly reduce airborne COVID-19 particles

As COVID-19 restrictions ease nationwide and more people host indoor gatherings, investing in a high efficiency particulate air (HEPA) purifier might not be a bad idea, says a University of Cincinnati College of Medicine researcher.

11 Jun 2021

Study identifies mechanisms by which COVID-19 can lead to Alzheimer's disease-like dementia

A new Cleveland Clinic-led study has identified mechanisms by which COVID-19 can lead to Alzheimer's disease-like dementia.

11 Jun 2021

Statins associated with reduced COVID-19 mortality and decreased need for ventilator support

Statins are medications widely used in the management of cardiovascular diseases and metabolic syndrome. Statins help lower serum lipids by blocking HMG-CoA reductase (3-hydroxy-3-methyl-glutaryl-coenzyme A reductase), the rate-limiting enzyme of cholesterol biosynthesis.

11 Jun 2021

Metformin prevents pulmonary or lung inflammation in animals infected with SARS-CoV-2

Metformin is a widely prescribed blood sugar-lowering drug. It is often used as an early therapy (in combination with diet and lifestyle changes) for type 2 diabetes, which afflicts more than 34 million Americans.

11 Jun 2021

Nanobodies from nanomice and llamas show potent neutralizing activity against SARS-CoV-2 variants

While several COVID-19 vaccines have been approved to date, the constant evolution of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) receptor-binding domain (RBD) has challenged the efficacy of these vaccines.

11 Jun 2021

Leaders call for renewed global solidarity to eradicate polio

Today, the Global Polio Eradication Initiative (GPEI) will launch the Polio Eradication Strategy 2022-2026: Delivering on a Promise at a virtual event, to overcome the remaining challenges to ending polio, including setbacks caused by COVID-19.

11 Jun 2021

Cross-sectional study explores differences in biomarkers in fulminant and non-fulminant COVID-19 myocarditis

Researchers from the US recently conducted a study to examine the clinical course and echocardiographic and lab testing across clinically defined fulminant and non-fulminant COVID-19 myocarditis. This study is published on the preprint server, medRxiv.*

11 Jun 2021

Largest U.S. study shares first results on effects of COVID-19 on cancer patients

In the largest study of its kind to date, researchers analyzing national data from more than 63,000 patients with cancer and a positive COVID-19 diagnosis report an increased risk of death among those who were older, male, had a higher number of comorbidities, and had hematologic cancers and recent chemotherapy treatments.

11 Jun 2021

In vivo protection from emerging SARS-CoV-2 variants by protein nanoparticle vaccine

Researchers in the United States have developed a new coronavirus disease 2019 (COVID-19) vaccine that induced potent neutralizing antibodies against variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in animal models.

10 Jun 2021

Shark vNAR antibodies inhibit SARS-CoV-2 variants in vitro

Researchers in the UK and Austria have identified a novel class of antibodies that is highly effective at neutralizing the original strain of severe acute respiratory syndrome (SARS-CoV-2) and maintaining blocking activity against certain viral variants that have emerged.

10 Jun 2021

Compound may block COVID-19 virus from entering lung cells, study reports

Research conducted at LSU Health New Orleans Neuroscience Center of Excellence reports that Elovanoids, bioactive chemical messengers made from omega-3 very-long-chain polyunsaturated fatty acids discovered by the Bazan lab in 2017, may block the virus that causes COVID-19 from entering cells and protect the air cells (alveoli) of the lung.

10 Jun 2021

Changes in community networks impact the ensuing spread of disease

The COVID-19 pandemic has made clear the importance of understanding precisely how diseases spread throughout networks of transportation. However, rigorously determining the connection between disease risk and changing networks--which either humans or the environment may alter--is challenging due to the complexity of these systems.

10 Jun 2021

DFG funds 51 new projects to carry out research into epidemics and pandemics

The Deutsche Forschungsgemeinschaft is funding more than 50 new interdisciplinary projects to carry out research into epidemics and pandemics.

10 Jun 2021

ACTG launches phase 1 HIV cure study evaluating two promising therapies

The AIDS Clinical Trials Group, the largest global HIV research network, today announced the launch of A5386, a phase 1 HIV cure study evaluating two promising therapies.

10 Jun 2021

Disease/Infection News

High single-dose efficacy of Pfizer vaccine against SARS-CoV-2 in older adults

New Astra-Zeneca B.1.351 vaccine AZD2816 strongly immunogenic against multiple SARS-CoV-2 variants of concern

Has COVID-19 vaccine confidence dropped following the pause of Johnson & Johnson/Janssen?

Scientists detect delayed and reduced antibody responses after BioNTech/Pfizer COVID-19 vaccination in older adults

SARS-CoV-2 infection detected in a poodle living with a COVID-19 positive family

NCCN experts provide new guidance on COVID-19 vaccines for cancer patients

HEPA air purifier can significantly reduce airborne COVID-19 particles

Study identifies mechanisms by which COVID-19 can lead to Alzheimer's disease-like dementia

Statins associated with reduced COVID-19 mortality and decreased need for ventilator support

Metformin prevents pulmonary or lung inflammation in animals infected with SARS-CoV-2

Nanobodies from nanomice and llamas show potent neutralizing activity against SARS-CoV-2 variants

Leaders call for renewed global solidarity to eradicate polio

Cross-sectional study explores differences in biomarkers in fulminant and non-fulminant COVID-19 myocarditis

Largest U.S. study shares first results on effects of COVID-19 on cancer patients

In vivo protection from emerging SARS-CoV-2 variants by protein nanoparticle vaccine

Shark vNAR antibodies inhibit SARS-CoV-2 variants in vitro

Compound may block COVID-19 virus from entering lung cells, study reports

Changes in community networks impact the ensuing spread of disease

DFG funds 51 new projects to carry out research into epidemics and pandemics

ACTG launches phase 1 HIV cure study evaluating two promising therapies

Decoding Cannabis: Differentiating Hemp and Marijuana

Deciphering the Microbiome with The Microsetta Initiative

Leveraging the power of automation to boost research

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