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Study rethinks the role of ACE2 in SARS-CoV-2 viral entry

Researchers in the US recently infected a series of human lung and head/neck cancer cell lines with SARS-CoV-2 that expressed varying levels of ACE2 and the TMPRSS2 protease to reassess their role in viral entrance.

8 Mar 2021

Researchers present fragment-based computational design of antibodies that target structured epitopes

A new study describes a novel fragment-based method to design antibody complementarity determining region (CDR) loops.

8 Mar 2021

Impairments in immune response contribute to severe COVID-19

New research by a team of scientists at University Hospital RWTH Aachen in Germany and Erasmus Medical Centre in The Netherlands characterized changes in CD8+ T cells in response to SARS-CoV-2.

8 Mar 2021

Apoptosis is an important mediator of pathogenesis in animal coronavirus infection

A new paper in the journal Life presents an early review of the viral factors involved in initiating and effecting apoptosis within infected cells.

8 Mar 2021

Small negative lifestyle changes during COVID-19 lockdown could accumulate, say researchers

An interesting new study by researchers in Australia, which has been published in the journal PLOS ONE, suggests that lifestyle changes due to pandemic restrictions on outdoor mobility have been small. But they warn that these may accumulate over time.

8 Mar 2021

Novel bioinformatics tool could help improve COVID-19 diagnosis

An interesting new study by researchers at the University of Liverpool, University of Bristol and Public Health England in the UK describes a novel bioinformatics tool used to detect subgenomic messenger ribonucleic acid (mRNA) sequences from the virus. This may help develop new diagnostic tools and model the transmission of the virus.

8 Mar 2021

How can physicians distinguish between COVID-19 persistence and SARS-CoV-2 reinfection?

One of the most challenging tasks of physicians has been differentiating between persistent COVID-19 and SARS-CoV-2 reinfection. Recently, a team of researchers analyzed SARS-CoV-2 sequences from the publicly available reports on reinfection and persistence. They further characterized the markers of reinfecting sequences and studied the mutation rate in newly evolved persistent variants.

8 Mar 2021

New method provides more control over gene drive releases

Powerful new genetic engineering methods have given scientists the potential to revolutionize several sectors of global urgency.

8 Mar 2021

Study shows why three-layered masks are safer than single or double-layered alternatives

If you are going to buy a face mask to protect yourself and others from COVID-19, make sure it's a three-layered mask. You might have already heard this recommendation, but researchers have now found an additional reason why three-layered masks are safer than single or double-layered alternatives.

8 Mar 2021

Monoclonal antibodies can be an effective tool in the global fight against malaria

Scientists at Walter Reed Army Institute of Research, in collaboration the Duke University, have confirmed that monoclonal antibodies can be an effective tool in the global fight against malaria.

8 Mar 2021

Study analyzes COVID fatality rate using age and GDP as proxies for the quality and abundance of healthcare

The COVID-19 pandemic has claimed over 2.5 million lives globally as of today. The case fatality rate (CFR) is an important parameter in COVID-19 mortality research and is defined as the ratio of the number of infected cases to the death toll number.

7 Mar 2021

Study confirms B.1.1.7 variant of SARS-CoV-2 is more transmissible

A new modeling study published in the journal Science estimates the B.1.1.7 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant is 43% to 90% more transmissible than previous coronavirus variants. The variant was initially found in Southeast England last fall.

7 Mar 2021

Saliva testing has high accuracy in detecting early cases of SARS-CoV-2

New research finds saliva testing has a high sensitivity for detecting severe acute respiratory syndrome 2 (SARS-CoV-2) in both symptomatic and asymptomatic patients.

7 Mar 2021

FDA authorizes first molecular non-prescription, at-home COVID-19 test

Today, the U.S. Food and Drug Administration issued an emergency use authorization (EUA) for the Cue COVID-19 Test for Home and Over The Counter (OTC) Use.

5 Mar 2021

FDA issues emergency use authorization for T-Detect COVID Test

Today, the U.S. Food and Drug Administration issued an emergency use authorization for the T-Detect COVID Test developed by Adaptive Biotechnologies.

5 Mar 2021

Study: Monoclonal antibody 'cocktail' effective against all known COVID-19 variants

A monoclonal antibody "cocktail" developed at Vanderbilt University Medical Center (VUMC) to neutralize the COVID-19 virus is effective against all known strains, or variants, of the virus, according to a report published in the journal Nature Medicine.

5 Mar 2021

People with intellectual disability more likely to die from COVID-19 than general population

Intellectual disability puts individuals at higher risk of dying earlier in life than the general population, for a variety of medical and institutional reasons.

5 Mar 2021

Multidrug-resistant S. aureus strains may be spreading between pigs, farmworkers in North Carolina

DNA sequencing of bacteria found in pigs and humans in rural eastern North Carolina, an area with concentrated industrial-scale pig-farming, suggests that multidrug-resistant Staphylococcus aureus strains are spreading between pigs, farmworkers, their families and community residents, and represents an emerging public health threat, according to a study led by researchers at the Johns Hopkins Bloomberg School of Public Health.

5 Mar 2021

ACTIV-3 clinical trial evaluating investigational COVID-19 therapies closes enrollment in two sub-studies

The ACTIV-3 clinical trial, which is evaluating the safety and efficacy of investigational therapeutics for COVID-19 in hospitalized patients, has closed enrollment in two sub-studies: one examining the investigational monoclonal antibody therapy VIR-7831, and another evaluating the investigational combination monoclonal antibody therapy containing BRII-196 and BRII-198.

5 Mar 2021

Children may transmit SARS-CoV-2 at same level as adults, suggests study

Researchers studied SARS-CoV-2 viral loads in over a thousand individuals, including both adults and children. They found the loads to be comparable, suggesting they may play an equal role in COVID-19 transmission.

5 Mar 2021

Disease/Infection News

Study rethinks the role of ACE2 in SARS-CoV-2 viral entry

Researchers present fragment-based computational design of antibodies that target structured epitopes

Impairments in immune response contribute to severe COVID-19

Apoptosis is an important mediator of pathogenesis in animal coronavirus infection

Small negative lifestyle changes during COVID-19 lockdown could accumulate, say researchers

Novel bioinformatics tool could help improve COVID-19 diagnosis

How can physicians distinguish between COVID-19 persistence and SARS-CoV-2 reinfection?

New method provides more control over gene drive releases

Study shows why three-layered masks are safer than single or double-layered alternatives

Monoclonal antibodies can be an effective tool in the global fight against malaria

Study analyzes COVID fatality rate using age and GDP as proxies for the quality and abundance of healthcare

Study confirms B.1.1.7 variant of SARS-CoV-2 is more transmissible

Saliva testing has high accuracy in detecting early cases of SARS-CoV-2

FDA authorizes first molecular non-prescription, at-home COVID-19 test

FDA issues emergency use authorization for T-Detect COVID Test

Study: Monoclonal antibody 'cocktail' effective against all known COVID-19 variants

People with intellectual disability more likely to die from COVID-19 than general population

Multidrug-resistant S. aureus strains may be spreading between pigs, farmworkers in North Carolina

ACTIV-3 clinical trial evaluating investigational COVID-19 therapies closes enrollment in two sub-studies

Children may transmit SARS-CoV-2 at same level as adults, suggests study

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