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Effect of mutations in the South African SARS-CoV-2 variant on transmission and neutralization

One such strain is the South African 501.V2 and UK B1.1.7 strains, which have been isolated from many countries and seem to spread faster than the ancestral strain. A preprint that recently appeared on the bioRxiv server reports the computational structure of this strain and the possible effect of the mutations on infectivity and neutralization.

12 Jan 2021

Bleeding disorder linked to poor clinical outcomes in COVID-19 patients

The novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the pathogen responsible for the ongoing coronavirus disease 2019 (COVID-19) pandemic. Approximately 20-55% of hospitalized COVID-19 patients are reported to have deranged hemostatic laboratory parameters, which suggests coagulopathy.

12 Jan 2021

Antigenic "supersite" could improve design of COVID-19 vaccines

Researchers in the United States have defined an antigenic “supersite” within the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that could have important implications for the design of vaccines to protect against coronavirus disease 2019 (COVID-19).

12 Jan 2021

Study reveals rising risk of mental health problems among COVID-19 health care professionals

The daily toll of COVID-19, as measured by new cases and the growing number of deaths, overlooks a shadowy set of casualties: the rising risk of mental health problems among health care professionals working on the frontlines of the pandemic.

12 Jan 2021

Hypoxia signaling pathway could lead to COVID-19 treatments

Researchers in Spain have demonstrated that studying the hypoxia signaling pathway could provide opportunities for treating coronavirus disease 2019 (COVID-19).

12 Jan 2021

K-State medical director contributes to research on SARS-CoV-2 transmission and quarantine periods

Kyle Goerl, the medical director of Kansas State University's Lafene Health Center, is part of a collaborative team that is providing research-based guidance during the COVID-19 pandemic.

12 Jan 2021

Leading pediatric hospital reveals top AI models in COVID-19 Grand Challenge

The top 10 results have been unveiled in the first-of-its-kind COVID-19 Lung CT Lesion Segmentation Grand Challenge, a groundbreaking research competition focused on developing artificial intelligence (AI) models to help in the visualization and measurement of COVID specific lesions in the lungs of infected patients, potentially facilitating to more timely and patient-specific medical interventions.

12 Jan 2021

Poor gut health may adversely affect COVID-19 prognosis

People infected with COVID-19 experience a wide range of symptoms and severities, the most commonly reported including high fevers and respiratory problems.

12 Jan 2021

Atmospheric particulate matter may influence the transmission and evolution of SARS-CoV-2

A recent study conducted at the University of Malta Medical School, Malta, has revealed that a drop in the level of particulate matter 2.5 (PM2.5), which are airborne pollutant particles with a diameter of 2.5 micrometer, in the atmosphere due to lockdown is associated with the arrival of a newer variant of SARS-CoV-2, which has eventually displaced the original virus after lockdown.

12 Jan 2021

Endothelial tissue injury significantly contributes to ARDS in COVID-19 patients, finds study

A recent study conducted by scientists from the Yokohama City University, Japan, has revealed that elevated alveolar endothelial injury markers in coronavirus disease 2019 (COVID-19) patients with acute respiratory distress syndrome (ARDS) are the main causative factors for alveolar barrier disruption. In COVID-19 patients with ARDS, endothelial injury persists for a longer time than epithelial injury.

12 Jan 2021

Will the Pfizer–BioNTech vaccine be effective against the new N501Y SARS-CoV-2 variant?

Researchers from Pfizer and the University of Texas, USA, have presented evidence showing that people in a previously reported trial of the mRNA-based COVID-19 vaccine, BNT162b2 – commonly known as the Pfizer-BioNTech COVID-19 vaccine – had equivalent neutralizing titers to the N501 and Y501 viruses.

12 Jan 2021

Researchers develop saliva testing method for SARS-CoV-2 using robotic RNA extraction

Researchers have developed an automated method of RNA extraction from saliva samples to allow faster processing times and high test sensitivity. Saliva testing could be used as an alternative to swab testing for coronavirus disease 2019 (COVID-19) surveillance.

12 Jan 2021

Could Vitamin D be an effective adjuvant to help mitigate the COVID-19 pandemic?

As the coronavirus pandemic continues to wreak havoc across the globe, there is a dire need for effective and safe therapeutics and vaccines. Overall, the pandemic has infected more than 90.87 million people and taken more 1.94 million lives.

12 Jan 2021

Headache as COVID-19 symptom could indicate milder disease, study finds

Researchers at the Hospital Universitario de La Princes in Madrid, Spain, found that patients with COVID-19 who developed headaches as an early symptom of infection had a milder illness and less risk of death.

12 Jan 2021

Study shows a 25% increase in food insufficiency during COVID-19 pandemic

A new study published in the American Journal of Preventive Medicine found a 25% increase in food insufficiency during the COVID-19 pandemic. Food insufficiency, the most extreme form of food insecurity, occurs when families do not have enough food to eat.

12 Jan 2021

ADC histogram analysis can predict tumor proliferation, survival in immunocompetent patients with PCNSL

The cover for issue 45 of Oncotarget features Figure 3, "Representative images of whole tumor volume segmentation of the co-registered T1 post-contrast sequence and apparent diffusion coefficient (ADC) map, yielding the corresponding ADC histogram distribution utilized for data analysis," recently published in "Diffusion-weighted MR imaging histogram analysis in HIV positive and negative patients with primary central nervous system lymphoma as a predictor of outcome and tumor proliferation" by Khan, et al.

12 Jan 2021

Wearable heart monitors and deep learning can provide early warning of SARS-CoV-2 infection

A recent study, appearing as a preprint on the medRxiv* server, reveals the possibility of early prediction of SARS-CoV-2 infection using data on the resting heart rate in the presymptomatic period.

12 Jan 2021

Researchers identify shorter form of ACE2 that lacks SARS-CoV-2 binding site

A shadow over the promising inhaled interferon beta COVID-19 therapy has been cleared with the discovery that although it appears to increase levels of ACE2 protein - coronavirus' key entry point into nose and lung cells - it predominantly increases levels of a short version of that protein, which the virus cannot bind to.

12 Jan 2021

Study shows COVID-19 pneumonia is different from typical pneumonia

Bacteria or viruses like influenza that cause pneumonia can spread across large regions of the lung over the course of hours. In the modern intensive care unit, these bacteria or viruses are usually controlled either by antibiotics or by the body's immune system within the first few days of the illness.

12 Jan 2021

Researchers study the behavior of regulatory T cells to understand periodontal disease

In diseases characterized by bone loss -such as periodontitis, rheumatoid arthritis, and osteoporosis- there is a lot that scientists still don't understand. What is the role of the immune response in the process? What happens to the regulatory mechanisms that protect bone?

12 Jan 2021

Disease/Infection News

Effect of mutations in the South African SARS-CoV-2 variant on transmission and neutralization

Bleeding disorder linked to poor clinical outcomes in COVID-19 patients

Antigenic "supersite" could improve design of COVID-19 vaccines

Study reveals rising risk of mental health problems among COVID-19 health care professionals

Hypoxia signaling pathway could lead to COVID-19 treatments

K-State medical director contributes to research on SARS-CoV-2 transmission and quarantine periods

Leading pediatric hospital reveals top AI models in COVID-19 Grand Challenge

Poor gut health may adversely affect COVID-19 prognosis

Atmospheric particulate matter may influence the transmission and evolution of SARS-CoV-2

Endothelial tissue injury significantly contributes to ARDS in COVID-19 patients, finds study

Will the Pfizer–BioNTech vaccine be effective against the new N501Y SARS-CoV-2 variant?

Researchers develop saliva testing method for SARS-CoV-2 using robotic RNA extraction

Could Vitamin D be an effective adjuvant to help mitigate the COVID-19 pandemic?

Headache as COVID-19 symptom could indicate milder disease, study finds

Study shows a 25% increase in food insufficiency during COVID-19 pandemic

ADC histogram analysis can predict tumor proliferation, survival in immunocompetent patients with PCNSL

Wearable heart monitors and deep learning can provide early warning of SARS-CoV-2 infection

Researchers identify shorter form of ACE2 that lacks SARS-CoV-2 binding site

Study shows COVID-19 pneumonia is different from typical pneumonia

Researchers study the behavior of regulatory T cells to understand periodontal disease

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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