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How have non-pharmaceutical interventions helped in COVID-19?

The COVID-19 pandemic shows no signs of abating, with outbreaks in many spots still occurring across the world. From the start, health organizations and governments were focused on implementing non-pharmaceutical interventions (NPIs) in the absence of any effective antivirals or vaccines.

9 Aug 2020

Speed of Novavax vaccine development does not compromise quality of the SARS-CoV-2 immunogen

A new study by researchers from the Scripps Research Institute and Novavax Inc. in the US affirms the structural integrity of the full-length SARS-CoV-2 spike glycoprotein immunogen. It enables the interpretation of immune responses to this multivalent nanoparticle immunogen. Their results are currently available on bioRxiv preprint server.

9 Aug 2020

Encouraging results from Phase I NovaVax SARS-CoV-2 nanoparticle vaccine trial

NVX-CoV2373, a recombinant nanoparticle vaccine developed by Novavax and manufactured at Emergent Biosolutions, was found to be well tolerated and immunogenic – inducing T-cell response and neutralization antibodies four-fold higher than the mean observed in hospitalized coronavirus disease (COVID-19) patients, shows a recent study available on the medRxiv* preprint server.

9 Aug 2020

Cutting edge synthetic peptides block SARS-CoV-2 (COVID-19)

Researchers at Ligandal Inc., the University of California San Francisco and Toyota Technological Institute at Chicago, have designed novel synthetic peptides that potently inhibit the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to infect host cells.

9 Aug 2020

Community-based sampling needed for COVID-19 control, say researchers

Researchers in the UK have warned that it will be essential to carry out community-based sampling in addition to symptomatic testing if the ongoing transmission of severe acute respiratory syndrome coronavirus 2 (SARs-CoV-2) is going to be properly understood and controlled.

9 Aug 2020

Probability analysis of Wuhan cases suggests COVID-19 may have a longer incubation period

By applying the renewal theory in probability to reduce recall bias in initial case reports, scientists have come up with a new estimate for the incubation period of COVID-19.

7 Aug 2020

Abnormal liver tests associated with poorer COVID-19 outcomes

Researchers at the Yale Liver Center found that patients with COVID-19 presented with abnormal liver tests at much higher rates than suggested by earlier studies.

7 Aug 2020

Study identifies five immune response markers that may predict COVID-19 patient outcomes

Galit Alter, PhD, Group Leader at the Ragon Institute of MGH, MIT and Harvard and Professor of Medicine at Harvard Medical School, and Helen Chu, MD, Associate Professor of Medicine, Division of Allergy and Infectious Diseases, University of Washington School of Medicine, and UW Medicine physician, have recently published a paper which identifies five immune response markers which, collectively, were able to correctly classify both convalescent COVID-19 patients and those who did not survive the disease.

7 Aug 2020

In rural Missouri, Latinos learn to contain and cope with the coronavirus

Francisco Bonilla is a pastor in Carthage, Missouri, tending to the spiritual needs of the town’s growing Latino community. He's also a media personality, broadcasting his voice far beyond the walls of Casa de Sanidad. Bonilla runs a low-power, Spanish-language radio station from the church.

7 Aug 2020

Test sites quickly attract thousands for COVID-19 vaccine study

Dr. Eric Coe jumped at the chance to help test a COVID-19 vaccine.

7 Aug 2020

Immunothrombotic dysregulation is key marker of disease severity in COVID-19

In severe cases of COVID-19, the infection can lead to obstruction of the blood vessels in the lung, heart and kidneys. Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have now shown that activated immune cells and blood platelets play a major role in these pathologies.

7 Aug 2020

Coronavirus-specific structure in cells may lead to new antiviral strategies

By visualizing coronavirus replication in an infected host cell, researchers may have answered a long-standing question about how newly synthesized coronavirus components are able to be incorporated into fully infectious viruses.

7 Aug 2020

New test can pinpoint which people with gonorrhea can be cured with ciprofloxacin

A test designed by UCLA researchers can pinpoint which people with gonorrhea will respond successfully to the inexpensive oral antibiotic ciprofloxacin, which had previously been sidelined over concerns the bacterium that causes the infection was becoming resistant to it.

7 Aug 2020

How misinformation undermines Australia's COVID-19 response

The current global climate of misinformation and myths about the origin, cure of, and measures required to deal with the COVID-19 pandemic has mired public acceptance of and compliance with governmental interventions and personal precautions.

7 Aug 2020

Providers participating in intervention resources are more likely to follow chronic opioid therapy guidelines

Results of a new study find that providers participating in an intervention with education and resources to help manage chronic opioid therapy for patients with HIV and chronic pain are more likely to adhere to national chronic opioid therapy guidelines compared to providers who do not take part.

7 Aug 2020

Study provides detailed insight into problems faced by patients recovering from COVID-19

Researchers have identified a pattern of longer-term symptoms likely to be experienced by people who were hospitalised with the COVID-19 infection.

7 Aug 2020

Oncologists interview physicians to identify specific communication related to COVID-19

When COVID-19 struck, health care pivoted hard. Any unnecessary procedures or appointments were postponed. For people with cancer, that pivot was particularly shattering.

7 Aug 2020

Study: Drinking honeysuckle decoction accelerates the negative conversion of COVID-19 patients

In a new study in Cell Discovery, Chen-Yu Zhang's group at Nanjing University and two other groups from Wuhan Institute of Virology and the Second Hospital of Nanjing present a novel finding that absorbed miRNA MIR2911 in honeysuckle decoction (HD) can directly target SARS-CoV-2 genes and inhibit viral replication. Drinking of HD accelerate the negative conversion of COVID-19 patients.

7 Aug 2020

Immune system derails during severe course of COVID-19

Contrary to what has been generally assumed so far, a severe course of COVID-19 does not solely result in a strong immune reaction - rather, the immune response is caught in a continuous loop of activation and inhibition.

6 Aug 2020

Study documents changes in hospital visitation and communication policies during COVID-19

Four months ago, Michigan glowed red on COVID-19 maps. Hundreds of patients packed hospital intensive care units in the southern part of the state, and hospitals statewide rapidly put strict new visitor policies in place to slow the spread of the new coronavirus.

6 Aug 2020

Disease/Infection News

How have non-pharmaceutical interventions helped in COVID-19?

Speed of Novavax vaccine development does not compromise quality of the SARS-CoV-2 immunogen

Encouraging results from Phase I NovaVax SARS-CoV-2 nanoparticle vaccine trial

Cutting edge synthetic peptides block SARS-CoV-2 (COVID-19)

Community-based sampling needed for COVID-19 control, say researchers

Probability analysis of Wuhan cases suggests COVID-19 may have a longer incubation period

Abnormal liver tests associated with poorer COVID-19 outcomes

Study identifies five immune response markers that may predict COVID-19 patient outcomes

In rural Missouri, Latinos learn to contain and cope with the coronavirus

Test sites quickly attract thousands for COVID-19 vaccine study

Immunothrombotic dysregulation is key marker of disease severity in COVID-19

Coronavirus-specific structure in cells may lead to new antiviral strategies

New test can pinpoint which people with gonorrhea can be cured with ciprofloxacin

How misinformation undermines Australia's COVID-19 response

Providers participating in intervention resources are more likely to follow chronic opioid therapy guidelines

Study provides detailed insight into problems faced by patients recovering from COVID-19

Oncologists interview physicians to identify specific communication related to COVID-19

Study: Drinking honeysuckle decoction accelerates the negative conversion of COVID-19 patients

Immune system derails during severe course of COVID-19

Study documents changes in hospital visitation and communication policies during COVID-19

Leveraging the power of automation to boost research

Automating research - solutions and best practices

How can microdialysis benefit drug development

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