Genomics

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Study uncovers a gene that plays key role in the evolution of limb development

University of Kentucky College of Medicine researchers were part of a new study that gives insight into how limb development evolved in vertebrates.

5 Oct 2021

Advanced technique offers new insights about the dynamics of gliomas

A team led by researchers at Weill Cornell Medicine, the New York Genome Center, Harvard Medical School, Massachusetts General Hospital and the Broad Institute of MIT and Harvard has profiled in unprecedented detail thousands of individual cells sampled from patients' brain tumors.

2 Oct 2021

UVA researchers identify 14 genes that cause obesity

Promising news in the effort to develop drugs to treat obesity: University of Virginia scientists have identified 14 genes that can cause and three that can prevent weight gain. The findings pave the way for treatments to combat a health problem that affects more than 40% of American adults.

1 Oct 2021

Researchers discover how a genetic mutation in mice and monkeys interferes with viruses

A nationwide team of researchers, led by scientists at University of Utah Health and The Rockefeller University, has determined how a genetic mutation found in mice and monkeys interferes with viruses such as HIV and Ebola.

30 Sep 2021

Researchers supplement synthetic biology toolkit to streamline investigations into genetic code expansion

One of modern biologists' most ambitious goals is to learn how to expand or otherwise modify the genetic code of life on Earth, in order to make new, artificial life forms.

30 Sep 2021

Machine learning may predict zoonotic potential of viral genomes

Most emerging infectious diseases of humans (like COVID-19) are zoonotic – caused by viruses originating from other animal species. Identifying high-risk viruses earlier can improve research and surveillance priorities.

28 Sep 2021

Supercoiling and looping can transmit mechanical stress along the DNA backbone, research shows

When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are known to influence every aspect of DNA activity, but how this happens has not been clear.

28 Sep 2021

Researchers create an integrated pipeline for performing genetic screening studies

Today's genetic engineers have a plethora of resources at their disposal: an ever-increasing number of massive datasets available online, highly precise gene editing tools like CRISPR, and cheap gene sequencing methods. But the proliferation of new technologies has not come with a clear roadmap to help researchers figure out which genes to target, which tools to use, and how to interpret their results. So, a team of scientists and engineers at Harvard's Wyss Institute for Biologically Inspired Engineering, Harvard Medical School (HMS), and the MIT Media Lab decided to make one.

28 Sep 2021

Research reveals nucleolar RNA interference based on C. elegans as a model organism

A research group led by Prof. GUANG Shouhong from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences, collaborating with Prof. FENG Xuezhu from the First Affiliated Hospital of USTC, revealed the nucleolar RNA interference based on Caenorhabditis elegans (C. elegans) as a model organism. The study was published in Nuclear Acids Research.

28 Sep 2021

Machine learning pinpoints genes that enable plants to grow more with less fertilizer

Machine learning can pinpoint "genes of importance" that help crops to grow with less fertilizer, according to a new study published in Nature Communications. It can also predict additional traits in plants and disease outcomes in animals, illustrating its applications beyond agriculture.

25 Sep 2021

Novel antibody candidate shows potent binding to diverse SARS-CoV-2 variant mutations

Twist Bioscience Corporation (Nasdaq: TWST) today reported that its internally-discovered antibody candidate TB202-3 (CoVIC-094), demonstrated potent binding to diverse SARS-CoV-2 variant mutations, including strains with the E484K, N501Y, D614G, Y453F and K417N mutations in pseudovirus assays, indicating this therapeutic antibody may be effective in treating many strains of COVID-19.

25 Sep 2021

Research explores the evolution and function of human growth hormone receptor gene

A new study delves into the evolution and function of the human growth hormone receptor gene and asks what forces in humanity's past may have driven changes to this vital piece of DNA.

25 Sep 2021

Scientists characterize new genetic variants that cause nonsyndromic neurodevelopmental disorder

Northwestern Medicine scientists have characterized several variants of the gene GRIK2 that cause nonsyndromic neurodevelopmental disorder (NDD), according to a study published in the American Journal of Human Genetics.

23 Sep 2021

Study provides novel insights into how KLF4 influences gene expression

A team led by researchers at Baylor College of Medicine has discovered a mechanism by which transcription factor KLF4 can help to organize chromatin, thus influencing gene expression.

23 Sep 2021

Discovery of genes opens the door to new treatments for obesity

Promising news in the effort to develop drugs to treat obesity: University of Virginia scientists have identified 14 genes that can cause and three that can prevent weight gain.

22 Sep 2021

Scientists use statistical mechanics to make sense of DNA folding

At more than 2 meters long, the human DNA molecule uses intricate folding patterns to fit into cells while locally unfolding to express genes. Such phenomena, however, are difficult to measure in experiments, and theoretical frameworks explaining them continue to be at odds with one another.

22 Sep 2021

Study paves the way for development of novel delivery systems to suppress HIV

In a new study supported by the National Institutes of Health, researchers used exosomes, tiny nanoparticles capable of being taken up by cells, to deliver novel protein into the cells of mice infected with HIV. The protein attached to HIVs' genetic material and prevented it from replicating, resulting in reduced levels of HIV in the bone marrow, spleen, and brain.

21 Sep 2021

Genomics

Study uncovers a gene that plays key role in the evolution of limb development

Advanced technique offers new insights about the dynamics of gliomas

UVA researchers identify 14 genes that cause obesity

Researchers discover how a genetic mutation in mice and monkeys interferes with viruses

Researchers supplement synthetic biology toolkit to streamline investigations into genetic code expansion

Machine learning may predict zoonotic potential of viral genomes

Supercoiling and looping can transmit mechanical stress along the DNA backbone, research shows

Researchers create an integrated pipeline for performing genetic screening studies

Research reveals nucleolar RNA interference based on C. elegans as a model organism

Machine learning pinpoints genes that enable plants to grow more with less fertilizer

Novel antibody candidate shows potent binding to diverse SARS-CoV-2 variant mutations

Research explores the evolution and function of human growth hormone receptor gene

Scientists characterize new genetic variants that cause nonsyndromic neurodevelopmental disorder

Study provides novel insights into how KLF4 influences gene expression

Discovery of genes opens the door to new treatments for obesity

Scientists use statistical mechanics to make sense of DNA folding

Study paves the way for development of novel delivery systems to suppress HIV

Differences in DNA methylation could accurately predict progression of liver disease

Study highlights the usefulness of organoids for basic research into coronaviruses

Study uncovers five new genetic loci predisposing to atopic dermatitis

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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