Genomics

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Research reveals a previously unknown role for a key transcription regulator linked to cancer

CTCF is a transcription factor that has been a research target due to its role in regulating a critical oncogene called MYC.

7 Sep 2021

Increased infectivity and immune evasion drive the spread of Delta SARS-CoV-2 variant

Findings suggest infection control measures against variants will need to continue in the post-vaccination era.

6 Sep 2021

New insights could help unlock the mystery of how lung cancer arises in never smokers

A genomic analysis of lung cancer in people with no history of smoking has found that a majority of these tumors arise from the accumulation of mutations caused by natural processes in the body.

6 Sep 2021

Researchers develop the smallest CRISPR to date for genome editing

A compact and efficient CRISPR-Cas system, named CasMINI, could be broadly useful for cell-engineering and gene-therapy applications because it is easier to deliver into cells. The findings appear in a study publishing September 3 in the journal Molecular Cell.

4 Sep 2021

Stanford researchers engineer an efficient, multi-purpose, mini CRISPR system

The common analogy for CRISPR gene editing is that it works like molecular scissors, cutting out select sections of DNA. Stanley Qi, assistant professor of bioengineering at Stanford University, likes that analogy, but he thinks it's time to reimagine CRISPR as a Swiss Army knife.

4 Sep 2021

Growing wheat varieties with biological nitrification inhibition trait could increase yields

An international collaboration has discovered and transferred to elite wheat varieties a wild-grass chromosome segment that causes roots to secrete natural inhibitors of nitrification, offering a way to dial back on heavy fertilizer use for wheat and to reduce the crop's nitrogen leakage into waterways and air, while maintaining or raising its productivity and grain quality, says a new report in the Proceedings of the National Academy of Sciences of the United States of America.

2 Sep 2021

Study suggests a biological basis behind instantaneous compatibility reaction

Have you ever met someone you instantly liked, or at other times, someone who you knew immediately that you did not want to be friends with, although you did not know why?

2 Sep 2021

Genomic autopsy reveals many genetic variants associated with cardiomyopathy

Postmortem genetic testing, or genomic autopsy, of young individuals who experienced sudden death revealed many had known genetic variants that are associated with cardiomyopathy, according to a Northwestern Medicine study published in JAMA Cardiology.

31 Aug 2021

Study uses novel technology to map the brain circuitry of spirituality

Scientists have long suspected that religiosity and spirituality could be mapped to specific brain circuits, but the location of those circuits remains unknown. Now, a new study using novel technology and the human connectome, a map of neural connections, has identified a brain circuit that seems to mediate that aspect of our personality. The work appears in Biological Psychiatry, published by Elsevier.

31 Aug 2021

New, one-stop method developed to avoid de novo genetic disease in embryos

De novo variants (DNVs), genetic mutations that were not previously identifiable in the family history of one of two prospective parents, may cause disease in any children they have.

31 Aug 2021

Finding the genetic cause of childhood epilepsy helps improve treatment and care

Epilepsy is one of the most common chronic neurological diseases, affecting more than 50 million people worldwide. Although it is believed that a large proportion of childhood-onset epilepsies are caused by genetic changes, it remains unknown precisely how many of these patients suffer from a genetic disorder and how often the treatment can be targeted to their specific genetic alteration.

31 Aug 2021

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Oncotarget published "Actionability evaluation of biliary tract cancer by genome transcriptome analysis and Asian cancer knowledgebase" which reported that it is necessary to investigate actionable genes and candidate drugs using a sophisticated knowledgebase and characterize BTCs immunologically for evaluating the actionability of molecular and immune therapies.

31 Aug 2021

Research sheds light on potential biological mechanisms that impact adherence to medications

How strictly patients follow a prescribed drug treatment (drug adherence) is clearly important if the therapy is to have maximum effect. A number of things can affect adherence, including behavioral and socioeconomic factors, but to date there have been few investigations into the role played by genetics. Now, research to be presented at the annual conference of the European Society of Human Genetics today has thrown new light on the potential biological mechanisms that can affect adherence to treatment.

31 Aug 2021

Polygenic risk scores could be used as a tool to help diagnose epilepsy

Although epilepsy is a relatively common condition, affecting approximately 1% of individuals worldwide, it is often difficult to diagnose in clinical practice, and it is estimated that up to a quarter of all cases may be misdiagnosed initially.

30 Aug 2021

Molecular autopsy of dried blood spots can identify underlying cause of sudden cardiac death in a young person

The underlying cause of sudden cardiac death (SCD) in a young person is often difficult to identify. A genetic analysis could provide more information in many cases, but blood samples are not collected routinely at the time of death, and DNA extracted from the tissues collected at autopsy is damaged because of the way they are fixed in formalin and paraffin-embedded.

30 Aug 2021

Oral bacteria of wild Swedish brown bears reveal history of human antibiotic use

An international team of researchers used historical museum collections to study the effects of human-made antibiotics over the entire history of their application.

27 Aug 2021

Large analysis identifies 579 genetic locations linked to anti-social behavior and addiction

An analysis of data from 1.5 million people has identified 579 locations in the genome associated with a predisposition to different behaviors and disorders related to self-regulation, including addiction and child behavioral problems.

27 Aug 2021

New MOGONET outperforms existing supervised multi-omics integrative analysis approaches

Genomics, proteomics, metabolomics, transcriptomics -- rapid advances in high-throughput biomedical technologies has enabled the collection of data with unprecedented detail from the growing number of omics.

27 Aug 2021

Study identifies 579 genomic regions associated with predisposition to self-regulating behaviors

Researchers have identified 579 locations in the human genome associated with a predisposition to self-regulation-related behaviors, including addiction and child behavioral problems. With data from 1.5 million people of European descent, the effort is considered to be one of the largest genome-wide association studies to date.

26 Aug 2021

Genetic background linked to elevated risk of omega-3 deficiency in Hispanic Americans

Hispanic people with a high percentage of American Indigenous ancestry are at increased risk of a nutritional deficiency that could affect their heart health and contribute to harmful inflammation, new research suggests.

26 Aug 2021

Genomics

Research reveals a previously unknown role for a key transcription regulator linked to cancer

Increased infectivity and immune evasion drive the spread of Delta SARS-CoV-2 variant

New insights could help unlock the mystery of how lung cancer arises in never smokers

Researchers develop the smallest CRISPR to date for genome editing

Stanford researchers engineer an efficient, multi-purpose, mini CRISPR system

Growing wheat varieties with biological nitrification inhibition trait could increase yields

Study suggests a biological basis behind instantaneous compatibility reaction

Genomic autopsy reveals many genetic variants associated with cardiomyopathy

Study uses novel technology to map the brain circuitry of spirituality

New, one-stop method developed to avoid de novo genetic disease in embryos

Finding the genetic cause of childhood epilepsy helps improve treatment and care

Study identifies actionable genes and candidate drugs in biliary tract cancer using a knowledgebase

Research sheds light on potential biological mechanisms that impact adherence to medications

Polygenic risk scores could be used as a tool to help diagnose epilepsy

Molecular autopsy of dried blood spots can identify underlying cause of sudden cardiac death in a young person

Oral bacteria of wild Swedish brown bears reveal history of human antibiotic use

Large analysis identifies 579 genetic locations linked to anti-social behavior and addiction

New MOGONET outperforms existing supervised multi-omics integrative analysis approaches

Study identifies 579 genomic regions associated with predisposition to self-regulating behaviors

Genetic background linked to elevated risk of omega-3 deficiency in Hispanic Americans

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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