Genomics

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Spatial transcriptomics-driven gene mapping offers new insights into inflammatory bowel disease

Using a technique called spatial transcriptomics, researchers at Karolinska Institutet in Sweden have analyzed the gene expression in the mouse colon and created a map showing where in the tissue individual genes are expressed.

12 Feb 2022

Circadian cycle controls the brain's ability to clear a protein linked to Alzheimer's disease

The brain's ability to clear a protein closely linked to Alzheimer's disease is tied to our circadian cycle, according to research published today in PLOS Genetics.

11 Feb 2022

Scientists introduce a genetic mutation to provide protection against Alzheimer's disease

Researchers from the Université Laval Faculty of Medicine and CHU de Québec–Université Laval Research Centre have successfully edited the genome of human cells grown in vitro to introduce a mutation providing protection against Alzheimer's disease.

10 Feb 2022

Epigenetic effects of pollutants may persist long enough to influence the evolutionary process

A new study led by University of Liverpool researchers has shown that the effects of pollutants can be transmitted over many generations in water fleas and may persist long enough to influence the evolutionary process.

10 Feb 2022

Super-resolution imaging of the human coronavirus genome during infection

Using high-throughput confocal super-resolution microscopy, scientists visualize the genomic material of the human coronavirus HCoV-229E.

9 Feb 2022

Defective mitochondrial DNA could be modified using gene-editing techniques

Defective mitochondria – the 'batteries' that power the cells of our bodies – could in future be repaired using gene-editing techniques.

8 Feb 2022

Compounds used to fight fungal diseases in plants may be driving antimicrobial resistance

New research from the University of Georgia has shown, for the first time, that compounds used to fight fungal diseases in plants are causing resistance to antifungal medications used to treat people.

8 Feb 2022

Regulatory sequences in the genomes of mammals help explain how cancer invades normal tissues

Researchers from UConn Heath and Yale University have made new advances connecting the evolution of pregnancy and cancer metastasis.

8 Feb 2022

New method decodes the role of DDX41 protein in preventing double-strand breaks in DNA

There are many different ways in which the genetic material DNA can be damaged, resulting in the development of diseases such as cancer. Certain forms of DNA damage are associated with so-called R-loops.

8 Feb 2022

Genetically informed brain atlases help identify hundreds of genomic loci

An international team of scientists has used atlases of the human brain informed by genetics to identify hundreds of genomic loci. Loci is plural for locus, and in genetics indicates the physical location of a gene or variant on a chromosome.

7 Feb 2022

Study identifies 29 new genetic variants linked to acne

A study of the genetics of acne has identified 29 regions of the genome that influence the condition. These genetic insights offer potential new targets for treatment. They may also help clinicians identify individuals at high risk of severe disease.

7 Feb 2022

Scientists reveal how droplets of transcription factors collectively read DNA regions to switch on genes

Life starts with one cell. When an organism develops, dividing cells specialize to form the variety of tissues and organs that build up the adult body, while keeping the same genetic material – contained in our DNA.

6 Feb 2022

Genomes of marine invertebrates found to be surprisingly stable across deep time

Scientists have discovered that the genomes of marine invertebrates have been surprisingly stable across deep time.

6 Feb 2022

Gene therapy helps heart muscle cells electrically activate in live mice

Biomedical engineers at Duke University have demonstrated a gene therapy that helps heart muscle cells electrically activate in live mice.

4 Feb 2022

Evaluating effects of D614G and P681R/H mutations on SARS-CoV-2 VOCs

Researchers evaluate how the D614G and P681H mutations alter the attributes of SARS-CoV-2 VOCs.

3 Feb 2022

Scientists identify genome regions linked to migraine risk

An international consortium of leading migraine scientists identified more than 120 regions of the genome that are connected to risk of migraine.

3 Feb 2022

Study identifies a genetic mutation linked to high risk of lethal childhood leukemia

A genetic variant changing just one base pair of nucleotides greatly increases risk of a high-risk subtype of childhood acute lymphoblastic leukemia (ALL), according to a Northwestern Medicine study published in Nature Genetics.

3 Feb 2022

CRISPRa method helps discover genes that play a role in immune cell biology

CRISPR genome editing has served as a powerful tool for deleting or altering DNA sequences and studying the resulting effect.

3 Feb 2022

Genome study reveals unexpected heterogeneity of human ribosomal RNA genes

A genome study undertaken by Johns Hopkins Kimmel Cancer Center researchers to look for variants in a gene considered a fundamental building block for microscopic structures that synthesize proteins took a surprising twist.

2 Feb 2022

Three different autism risk genes found to have similar effects on brain development

Autism spectrum disorder has been associated with hundreds of different genes, but how these distinct genetic mutations converge on a similar pathology in patients has remained a mystery.

2 Feb 2022

Genomics

Spatial transcriptomics-driven gene mapping offers new insights into inflammatory bowel disease

Circadian cycle controls the brain's ability to clear a protein linked to Alzheimer's disease

Scientists introduce a genetic mutation to provide protection against Alzheimer's disease

Epigenetic effects of pollutants may persist long enough to influence the evolutionary process

Super-resolution imaging of the human coronavirus genome during infection

Defective mitochondrial DNA could be modified using gene-editing techniques

Compounds used to fight fungal diseases in plants may be driving antimicrobial resistance

Regulatory sequences in the genomes of mammals help explain how cancer invades normal tissues

New method decodes the role of DDX41 protein in preventing double-strand breaks in DNA

Genetically informed brain atlases help identify hundreds of genomic loci

Study identifies 29 new genetic variants linked to acne

Scientists reveal how droplets of transcription factors collectively read DNA regions to switch on genes

Genomes of marine invertebrates found to be surprisingly stable across deep time

Gene therapy helps heart muscle cells electrically activate in live mice

Evaluating effects of D614G and P681R/H mutations on SARS-CoV-2 VOCs

Scientists identify genome regions linked to migraine risk

Study identifies a genetic mutation linked to high risk of lethal childhood leukemia

CRISPRa method helps discover genes that play a role in immune cell biology

Genome study reveals unexpected heterogeneity of human ribosomal RNA genes

Three different autism risk genes found to have similar effects on brain development

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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