Histology & Microscopy

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Study reveals key details of how DREADD technology highjacks neuronal activity

Understanding of how neuronal activity modulates brain function is a key first step towards creating more effective drugs to treat a variety of neuropsychiatric illnesses, including depression, anxiety, schizophrenia, substance abuse, epilepsy, and others.

30 Nov 2022

Powerful imaging tool creates 3D atlas of the spectrum of tuberculous and COVID-19 lung lesions

Gross anatomy reveals three-dimensional shapes of pathology at a large scale. Histology, in contrast, reveals the microscopic anatomy of biological structures. But that magnification comes at a cost -; histology shows only two-dimensional shapes because it studies small, flat slices of stained tissue.

29 Nov 2022

Imaging brain activity deep in the cortex of freely moving mouse

How does the brain produce behavior? Studying the brain during behavior is most informative when the animal is free to interact with its environment in any way it chooses.

28 Nov 2022

Study reveals structural insights into the elusive tankyrase protein that fuels bowel cancer

Scientists have revealed the inner workings of a key protein involved in a wide range of cellular processes – potentially paving the way for better and less toxic cancer drugs.

23 Nov 2022

Bruker announces acquisition of Inscopix for neuroscience research

Bruker Corporation today announced the acquisition of Inscopix, Inc., a neuroscience pioneer and market leader of miniaturized microscopes, known as miniscopes, for freely moving animal brain imaging.

From Bruker Nano Surfaces and Metrology 16 Nov 2022

Study illuminates how a typical gut bacterium spreads through the body

A typical gut bacterium that can spread through the body and cause a serious infection resists natural immune defenses and antibiotics by enhancing its protective outer layer, known as the cell envelope, according to a new study by Weill Cornell Medicine investigators.

10 Nov 2022

New tool maps how breast cancer grows in previously unseen detail

New technology can trace which populations of breast cancer cells are responsible for the spread of the disease, and for the first time highlights how the location of cancer cells could be as important as mutations in tumor growth.

9 Nov 2022

Researchers use deep neural networks to virtually stain microscopic images of unlabeled tissue

In the hospital, there is a group of doctors who use tissue samples as "evidence materials", analyze the evidence using knives, slicers and microscopes to extract clues from the tissue samples, and provide patients with "verdicts" -; diagnostic reports.

31 Oct 2022

Scientists map structure of the hepatitis C virus E1E2 glycoprotein complex

A team led by scientists at Scripps Research and the University of Amsterdam has achieved an important goal in virology: mapping, at high resolution, critical proteins that stud the surface of the Hepatitis C virus (HCV) and enable it to enter host cells.

20 Oct 2022

New noninvasive neuroimaging method for direct mapping of neuronal activity in a living mouse's brain

A new noninvasive neuroimaging method dubbed DIANA (direct imaging of neuronal activity) allows direct mapping of neuronal activity in a living mouse's brain at high resolution, researchers report.

14 Oct 2022

Advanced cryo-electron microscope reveals how poliovirus takes over human cells

For the first time, researchers at Umeå University, Sweden, can now show how the dreaded poliovirus behaves when it takes over an infected cell and tricks the cell into producing new virus particles.

12 Oct 2022

Protoporphyrin IX delayed fluorescence imaging as a modality for hypoxia-based oncologic surgical guidance

In the surgical treatment of cancer, distinguishing between tumors and healthy tissues is critical. Fluorescent markers can help to do this, by enhancing the contrast of tumors during surgery.

11 Oct 2022

Light-Seq technology for barcoding and deep-sequencing selected cell populations in tissues

Under the microscope, researchers often observe different cell types organizing themselves in peculiar patterns within tissues, or sometimes a rare cell type that stands out by occupying a unique position, exhibiting an unusual shape, or expressing a specific biomarker molecule.

10 Oct 2022

Self-teaching deep learning algorithm can find similar cases in large pathology image repositories

Rare diseases are often difficult to diagnose and predicting the best course of treatment can be challenging for clinicians.

10 Oct 2022

Scientists visualize antibiotics in action inside a pathogenic bacterium

Every living cell relies on proteins in order to function and the process of protein synthesis – translation – is critical for survival.

28 Sep 2022

Researchers reveal native 3D structure of the ciliary base for the first time

Cilia are small hair-like organelles that extend from cells and perform many functions, including motility and signaling.

19 Sep 2022

Researchers use sea anemone to understand how behavior impacts body shape during early development

As humans, we know that an active lifestyle gives us some control over our form. When we hit the pavement, track our steps, and head to the gym, we can maintain muscle development and reduce body fat.

16 Sep 2022

Study reveals cellular underpinnings of motor memory acquisition and consolidation

When you are first learning how to ride a bicycle or play a musical instrument, your physical movements are uncoordinated at best.

14 Sep 2022

New technology reveals cellular changes across neural-epithelial-vascular complex in choroideremia

By combining traditional eye imaging techniques with adaptive optics - a technology that enhances imaging resolution - researchers at the National Eye Institute have shown for the first time how cells across different tissue layers in the eye are affected in people with choroideremia, a rare genetic disorder that leads to blindness.

13 Sep 2022

LJI scientists uncover major clue toward developing new antiviral therapies against flaviviruses

Zika virus has a trick up its sleeve. Once inside the body, the virus likes to make a bee line for dendritic cells, the cells we rely on to launch an effective immune response.

12 Sep 2022