Molecular & Structural Biology

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The basal forebrain may hold clues to food avoidance behavior

After fasting for 24 hours the typical laboratory mouse spends much time eating. Surprisingly, this is not what Jay M. Patel saw when he was studying basal forebrain circuits in mice.

18 Jun 2019

Researchers discover redundancies in immune cells

Researchers at ETH Zurich have discovered redundancies in the biochemical signaling pathways of immune cells. This finding has important implications for advances in cancer immunotherapy, among other areas.

18 Jun 2019

Researchers develop technique to track proteins on the surfaces of endoplasmic reticulum in cells

Researchers from Kanazawa University on the development of a technique to closely track a specific protein on the surfaces of endoplasmic reticulum (ER) in cells. Their findings are published in Bioorganic and Medicinal Chemistry.

17 Jun 2019

Researchers examine transport mechanism of bacterial membrane protein

An international research team has investigated the transport mechanism of a bacterial membrane protein using an artificially produced antibody fragment.

17 Jun 2019

Researchers develop new 3D tissue imaging technique to study disease at cellular level

To diagnose and treat diseases like cancer, scientists and doctors must understand how cells respond to different medical conditions and treatments.

14 Jun 2019

Mutant bacterial receptor could help identify therapeutic compounds that inhibit quorum sensing

Researchers have developed a new mutant version of a receptor used by a bacterial pathogen for a chemical communication process called quorum sensing, according to a study published June 13 in the open-access journal PLOS Pathogens by Bonnie Bassler of Princeton University, and colleagues.

From PLOS ONE 14 Jun 2019

Research suggests new way to improve the efficacy of arthritis drug

Attaching a removable lock to an arthritis drug can make it safer and more effective, according to a new study publishing June 13 in the open-access journal PLOS Biology led by Wen-Wei Lin of Kaohsiung Medical University, Taiwan.

From PLOS ONE 14 Jun 2019

Researchers uncover new mechanism by which cells communicate in inflammatory processes

A research group from MedUni Vienna and CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences has discovered a new mechanism by which cells communicate in inflammatory processes.

14 Jun 2019

Ultra-Small Microelectrode Biosensors for Brain Injury Analysis

An interview with Stéphane Marinesco, discussing the development of ultra-small microelectrode biosensors for the analysis of traumatic brain injuries.

From Pittcon 14 Jun 2019

Super-Resolution Raman Imaging with Plasmonic Substrates

Renee Frontiera discusses the development of a super-resolution Raman microscope that could one day supersede fluorescence-based super-resolution microscopes.

From Pittcon 14 Jun 2019

Polycomb protein EED plays a complex role in brain development

The dentate gyrus (DG) is the input region of the hippocampus and plays an important role in learning and memory.

13 Jun 2019

Norovirus structures could help develop therapeutics to fight food-borne illness

Noroviruses are a leading cause of food-borne illness outbreaks, accounting for 58% of all outbreaks and cause 685 million cases worldwide each year. There is no effective therapeutic against them. Having knowledge of the intricate structure of the outer layer of noroviruses, the capsid, which allows the virus to attach to its human host, could help in vaccine development.

13 Jun 2019

Researchers develop first blood-brain barrier chip using stem cells

Researchers at Ben-Gurion University of the Negev and Cedars-Sinai Medical Center in Los Angeles have, for the first time, duplicated a patient's blood-brain barrier, creating a human BBB chip with stem cells, which can be used to develop personalized medicine and new techniques to research brain disorders.

13 Jun 2019