Molecular & Structural Biology

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CRISPR uncovers which gene fusions are critical for growth of cancer cells

In the first large-scale analysis of cancer gene fusions, which result from the merging of two previously separate genes, researchers at the Wellcome Sanger Institute, EMBL-EBI, Open Targets, GSK and their collaborators have used CRISPR to uncover which gene fusions are critical for the growth of cancer cells.

16 May 2019

Over-fed bacteria in the gut promote disease development

Since the end of the Second World War, along with the growing prosperity and the associated changes in lifestyle, numerous new and civilisation-related disease patterns have developed in today's industrialised nations.

16 May 2019

Scientists unravel how intelligent neural network predicts the functions of proteins

Intelligent virtual companions like Alexa, Siri, and Google Assistant have long become integrated into our everyday lives. And intelligent computational programs, so-called algorithms, have also evolved as an integral tool in scientific research.

16 May 2019

Researchers use cutting-edge technology to read the dark heart of chromosomes

Although the genomes of thousands of plant and animal species have been sequenced, for most of these genomes a significant portion is missing — the highly repetitive DNA.

15 May 2019

Physician training makes doctors' DNA to age six times faster than normal

In just a few short weeks, tens of thousands of newly minted doctors will start the most intense year of their training: the first year of residency, also called the intern year.

15 May 2019

Fruit fly study shows role of unexplored neural circuit in modulating memory strength

Learning to avoid negative experiences requires an interplay of two distinct brain circuits, one to interpret "Yikes!" and drive learning, and the other, unexpectedly, to dial in the strength of that memory, a new fruit fly study shows.

15 May 2019

Oxidative stress acts directly on telomeres to hasten cellular aging, study reveals

The same sources thought to inflict oxidative stress on cells- pollution, diesel exhaust, smoking and obesity- also are associated with shorter telomeres, the protective tips on the ends of the chromosomal shoelace.

14 May 2019

Researchers elucidate the mechanism underlying dead-zone generation in circadian clocks

Most organisms on Earth have circadian clocks. In mammals, the circadian pacemaker is located in the suprachiasmatic nucleus of the brain.

14 May 2019

Probiotic-derived molecule optimizes the immune system to combat viral inflammatory diseases

The existence of certain microorganisms in your gut may bolster the immune system's ability to fend off a herpes viral attack that can cause fatal brain inflammation, reports a new City of Hope-led study.

14 May 2019

Different levels of two molecules from same family can influence prognosis of liposarcoma

Researchers at Hiroshima University have found that different levels of two molecules of the same family--TIMP-1 and TIMP-4--can influence prognosis of liposarcoma.

14 May 2019

Brazilian researchers develop new strategy to starve triple negative breast cancer cells

A team of Brazilian researchers has developed a strategy that slows the growth of triple negative breast cancer cells by cutting them off from two major food sources.

13 May 2019

Research on repetitive worm behavior may shed light on repetition in humans

Repetition can be useful if you're trying to memorize a poem, master a guitar riff, or just cultivate good habits.

13 May 2019

Nanotubes enable movement of toxic protein linked to Huntington's disease

A toxic protein linked to Huntington's disease can move from neuron to neuron through a nanotube tunnel whose construction is initiated by a protein called Rhes, say scientists at Scripps Research.

11 May 2019

Study reveals how dengue virus replicates in infected cells

The nonstructural protein 1 of the dengue virus interacts with another viral protein called NS4A-2K-4B to enable viral replication, according to a study published May 9 in the open-access journal PLOS Pathogens by Ralf Bartenschlager of the University of Heidelberg, and colleagues.

10 May 2019

Egg yolk precursor protein plays key role in regulating mosquitos’ attraction to humans

Feeding mosquitoes sugar makes them less attracted to humans, a response that is regulated by the protein vitellogenin, according to a study publishing May 9 in the open-access journal PLOS Biology by Jessica Dittmer, Paolo Gabrieli and colleagues at the Università degli Studi di Pavia in Italy.

10 May 2019

New computational framework reveals impact of arthritis drugs on gene expression

A new computational framework has revealed key differences between four rheumatoid arthritis medications and their impact on biological pathways in mice.

10 May 2019

AMP offers recommendations to aid in design and validation of clinical CYP2C9 assays

The Association for Molecular Pathology, the premier global, molecular diagnostic professional society, today published consensus, evidence-based recommendations to aid in the design and validation of clinical CYP2C9 assays, promote standardization of testing across different laboratories and improve patient care.

10 May 2019

Molecular & Structural Biology

CRISPR uncovers which gene fusions are critical for growth of cancer cells

Over-fed bacteria in the gut promote disease development

Scientists unravel how intelligent neural network predicts the functions of proteins

Researchers use cutting-edge technology to read the dark heart of chromosomes

Physician training makes doctors' DNA to age six times faster than normal

Fruit fly study shows role of unexplored neural circuit in modulating memory strength

Oxidative stress acts directly on telomeres to hasten cellular aging, study reveals

Researchers elucidate the mechanism underlying dead-zone generation in circadian clocks

Probiotic-derived molecule optimizes the immune system to combat viral inflammatory diseases

Different levels of two molecules from same family can influence prognosis of liposarcoma

Brazilian researchers develop new strategy to starve triple negative breast cancer cells

Research on repetitive worm behavior may shed light on repetition in humans

Nanotubes enable movement of toxic protein linked to Huntington's disease

Study reveals how dengue virus replicates in infected cells

Egg yolk precursor protein plays key role in regulating mosquitos’ attraction to humans

New computational framework reveals impact of arthritis drugs on gene expression

AMP offers recommendations to aid in design and validation of clinical CYP2C9 assays

New machine-learning approach discovers mechanism that helps antibiotics kill bacteria

Scientists successfully create melanocyte precursor cells using stem cell technology

Purdue researchers develop new way to view and classify protein 3D shapes

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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