Molecular & Structural Biology

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Researchers map bone-marrow microenvironment to shed new light on leukemia

Stem cells are surrounded and protected by the stem-cell niche - the microenvironment - of the tissue in which they are found.

24 May 2019

Spatial configuration of the genome is not inherited, but set up during embryogenesis

The architecture of the DNA-protein complexes that make up the genome in each cell nucleus regulates the course of early embryonic development.

23 May 2019

Newly discovered molecules safely halt the gene editing process

Scientists have discovered two non-toxic molecules that safely halt the CRISPR-Cas9 gene editing process.

22 May 2019

Scientists unravel how DNA organizes and preserves genetic information

Two scientists at the Johns Hopkins University School of Medicine have unraveled aspects of how DNA organizes and preserves genetic information.

From Johns Hopkins Medicine 22 May 2019

Researchers decode how molecular escorts help prevent cancer

The anti-tumor protein p53 can decide on the life or death of a cell: If it detects damage in the cell's genome, the protein pushes the cell to suicide.

22 May 2019

Study provides new insights into key beneficial function of small ancient protein

Cell boundaries are made of lipids. When cells are severely damaged, these lipids need to be rapidly removed to avoid toxicity and facilitate tissue healing. Researchers have discovered that a small ancient protein, Serum Amyloid A (SAA), plays a previously unknown key role in this vital process.

21 May 2019

Cutting the test time for disease biomarkers using extracellular vesicles

When an individual has cancer, or any number of other diseases, early detection can make a huge difference in the outcome. A research team led by the University of Notre Dame is working to cut the test time for disease biomarkers.

21 May 2019

Scientists create bacteria with man-made DNA

In a landmark research study, a living organism (E. coli) has been made using entirely human-made DNA.

21 May 2019

Researchers map molecular structure and dynamics of one of Alzheimer's stickier culprits

In a new study published in Proceedings of the National Academy of Sciences, researchers from the University of Colorado Denver and Binghamton University are the first to map the molecular structure and dynamics of an aggressive protein modification that spurs on Alzheimer's disease.

18 May 2019

Researchers unravel mechanistic origin of cell-size control

Working with bacteria, a multidisciplinary team at the University of California San Diego has provided new insight into a longstanding question in science: What are the underlying mechanisms that control the size of cells?

17 May 2019

Insulin-producing beta cells can change their function in diabetes, reveals study

A revolutionary new study using only materials derived from humans has revealed that insulin-producing beta cells can change their function in diabetes - and that this change may be reversible.

17 May 2019

CRISPR uncovers which gene fusions are critical for growth of cancer cells

In the first large-scale analysis of cancer gene fusions, which result from the merging of two previously separate genes, researchers at the Wellcome Sanger Institute, EMBL-EBI, Open Targets, GSK and their collaborators have used CRISPR to uncover which gene fusions are critical for the growth of cancer cells.

16 May 2019

Molecular & Structural Biology

Researchers map bone-marrow microenvironment to shed new light on leukemia

Spatial configuration of the genome is not inherited, but set up during embryogenesis

Newly discovered molecules safely halt the gene editing process

Scientists unravel how DNA organizes and preserves genetic information

Researchers decode how molecular escorts help prevent cancer

Study provides new insights into key beneficial function of small ancient protein

Cutting the test time for disease biomarkers using extracellular vesicles

Scientists create bacteria with man-made DNA

Researchers map molecular structure and dynamics of one of Alzheimer's stickier culprits

Researchers unravel mechanistic origin of cell-size control

Insulin-producing beta cells can change their function in diabetes, reveals study

CRISPR uncovers which gene fusions are critical for growth of cancer cells

Over-fed bacteria in the gut promote disease development

Scientists unravel how intelligent neural network predicts the functions of proteins

Researchers use cutting-edge technology to read the dark heart of chromosomes

Physician training makes doctors' DNA to age six times faster than normal

Fruit fly study shows role of unexplored neural circuit in modulating memory strength

Oxidative stress acts directly on telomeres to hasten cellular aging, study reveals

Researchers elucidate the mechanism underlying dead-zone generation in circadian clocks

Probiotic-derived molecule optimizes the immune system to combat viral inflammatory diseases

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