Molecular & Structural Biology

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Researchers report surprising first steps that promote resistance to commonly prescribed antibiotics

Antibiotic resistance is a global health threat. In 2019 alone, an estimated 1.3 million deaths were attributed to antibiotic resistant bacterial infections worldwide.

31 Mar 2023

Developing lipid nanoparticles to carry mRNA specifically to the pancreas

Therapeutics that use mRNA - like some of the COVID-19 vaccines - have enormous potential for the prevention and treatment of many diseases.

31 Mar 2023

New model of DNA flexibility opens up the possibility of getting closer to the chromatin scale

In both physics and chemistry, the mesoscopic scale refers to the length scale on which the properties of a material or phenomenon can be studied, without entering into a discussion about the behavior of individual atoms.

31 Mar 2023

Researchers develop a biosensor for real time detection of the G-protein molecular switch

DGIST (President: Kook Yang) announced on March 16th that the research team led by Professor Byung-Chang Suh has investigated for the first time the real-time effect of the G-protein cycle, which acts as a switch in our body, on the structural changes in G protein-coupled receptors (GPCRs).

31 Mar 2023

New structural details of the COVID-19 virus revealed

A new study led by Worcester Polytechnic Institute (WPI) brings into sharper focus the structural details of the COVID-19 virus, revealing an elliptical shape that "breathes," or changes shape, as it moves in the body.

30 Mar 2023

New model captures the complex shapes and biophysical properties of neurons

The thalamus and thalamic reticular nucleus are situated at the heart of the mammalian brain and are known to play a key role in a wide range of functions, including the transmission of sensory information to the cortex and the transition between brain states such as sleep and wakefulness.

30 Mar 2023

Riboswitch may be the key to advance gene therapy, regenerative medicine

The Okinawa Institute of Science and Technology, in collaboration with Astellas Pharma Inc., has developed a new toolkit that uses small molecules to control the activity of a piece of synthetic RNA, and ultimately regulate gene expression.

30 Mar 2023

The origin of congenital coronary fistulae discovered

Scientists of the Department of Animal Biology of the University of Malaga have discovered the cellular mechanism that originates coronary arterio-ventricular fistulae, a congenital anomaly that, in severe cases, may result in death.

30 Mar 2023

Cellular senescence and extracellular vesicles partner to play a role in triggering amyloidosis

A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, "Senescence and extracellular vesicles: novel partners in vascular amyloidosis."

29 Mar 2023

Advancements and challenges of constructing artificial mitochondria and chloroplasts

Energy production in nature is the responsibility of chloroplasts and mitochondria and is crucial for fabricating sustainable, synthetic cells in the lab.

28 Mar 2023

Newly designed molecule disrupts the infection mechanism of SARS-CoV-2

A team of scientists led by the Department of Energy's Oak Ridge National Laboratory designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.

28 Mar 2023

Chronological and biological age may be important determinants of vaccine-preventable outcomes

A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, "Parsing chronological and biological age effects on vaccine responses."

27 Mar 2023

Computational approach used to understand the mechanisms of protein folding in tauopathies

A team at UT Southwestern has developed a computational approach to uncover mechanisms of protein misfolding linked to neurodegenerative diseases.

27 Mar 2023

Understanding Mtb's nitrogen metabolism could pave the way for more effective TB treatments

Development of new drugs to effectively target the bacterium that causes tuberculosis (TB) could be one step closer following an important discovery from the University of Surrey.

27 Mar 2023

New technology can rapidly analyze the metabolic state of lipids in cells

Professor Itaru Hamachi, Lecturer Tomonori Tamura, and Assistant Professor Masaki Tsuchiya of Kyoto University have developed a new technology called O-ClickFC (Organelle-selective click labeling with flow cytometry), which can, at a very high speed, analyze the metabolic state of lipids in cells.

27 Mar 2023

Mea6 elimination in oligodendrocytes impairs white matter structure and lipid content

More than half amount in adult human brain is made up of white matter. Lipid-rich myelin is a special structure formed by oligodendrocytes wrapping neuronal axons to form the major components of white matter.

27 Mar 2023

Cryo-EM provides structural insights into a specific protein involved in Hailey-Hailey disease

Hailey-Hailey disease is a rare, inherited condition characterized by patches of blisters appearing mainly in the skin folds of the arm pits, groin and under the breasts.

24 Mar 2023

Antibodies produced by newly developed mRNA vaccines are transferred from pregnant rabbits to offspring

Newly developed mRNA vaccines against Zika virus and HIV-1 produced strong antibody responses that transferred from pregnant rabbits to their offspring, researchers report March 24th in the journal Molecular Therapy.

24 Mar 2023

New high resolution model of the human hippocampus CA1 area developed

A new high resolution model of the CA1 region of the human hippocampus has been developed by the Institute of Biophysics of the Italian National Research Council and University of Modena e Reggio Emilia, part of the Human Brain Project.

24 Mar 2023

Candida auris escapes innate immunity through metabolic reprogramming

A team of scientists from Australia and Israel demonstrates that Candida auris, a fungus associated with life-threatening and drug-resistant infections, escapes the host's innate immune response by destroying macrophages through metabolic reprogramming. The fungus is also capable of escaping antimicrobial inflammatory response.

23 Mar 2023

Molecular & Structural Biology

Researchers report surprising first steps that promote resistance to commonly prescribed antibiotics

Developing lipid nanoparticles to carry mRNA specifically to the pancreas

New model of DNA flexibility opens up the possibility of getting closer to the chromatin scale

Researchers develop a biosensor for real time detection of the G-protein molecular switch

New structural details of the COVID-19 virus revealed

New model captures the complex shapes and biophysical properties of neurons

Riboswitch may be the key to advance gene therapy, regenerative medicine

The origin of congenital coronary fistulae discovered

Cellular senescence and extracellular vesicles partner to play a role in triggering amyloidosis

Advancements and challenges of constructing artificial mitochondria and chloroplasts

Newly designed molecule disrupts the infection mechanism of SARS-CoV-2

Chronological and biological age may be important determinants of vaccine-preventable outcomes

Computational approach used to understand the mechanisms of protein folding in tauopathies

Understanding Mtb's nitrogen metabolism could pave the way for more effective TB treatments

New technology can rapidly analyze the metabolic state of lipids in cells

Mea6 elimination in oligodendrocytes impairs white matter structure and lipid content

Cryo-EM provides structural insights into a specific protein involved in Hailey-Hailey disease

Antibodies produced by newly developed mRNA vaccines are transferred from pregnant rabbits to offspring

New high resolution model of the human hippocampus CA1 area developed

Candida auris escapes innate immunity through metabolic reprogramming

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