Molecular & Structural Biology

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Genes known to control eye color are essential for retinal health

Metabolic pathways consist of a series of biochemical reactions in cells that convert a starting component into other products.

23 Mar 2023

New way to safely, sustainably synthesize a molecule with remarkable anticancer properties

Plants produce all types of curious chemicals. Some deter predators. Some smell wonderful. Some even have medicinal value.

23 Mar 2023

Modulating the function of immune cells to recover aging muscle's regenerative capacity

Muscle is able to regenerate through a process that involves multiple steps and players, including the immune system.

23 Mar 2023

Study outlines a meta-scale approach to quantifying the human proteome

A major puzzle of biology is that while the human genome contains roughly 20,000 genes, many comparatively primitive organisms - including the universally-studied worm C. elegans - have almost the same number of genes.

23 Mar 2023

Understanding the structure of CFTR could help design more effective therapies for cystic fibrosis

Scientists at St. Jude Children's Research Hospital and Rockefeller University have combined their expertise to gain a better understanding of the cystic fibrosis transmembrane conductance regulator (CFTR).

23 Mar 2023

Study discovers a protein controlling resistance to chemotherapy

Despite the recent development of new targeted therapies, chemotherapies remain the most frequently used treatment to treat patients suffering from advanced cancers.

22 Mar 2023

Researchers discover how a single mechanosensitive protein induces fibrosis

Researchers from Kyushu University have found how a single mechanosensitive protein induces the process that thickens and scars tissue, known as fibrosis. The protein, called VGLL3, was shown to contribute to fibrosis in multiple organs.

22 Mar 2023

New insights into how the brain's 'internal compass' works

Scientists have gained new insights into the part of the brain that gives us a sense of direction, by tracking neural activity with the latest advances in brain imaging techniques.

22 Mar 2023

Age-induced methylation changes in the sperm epigenome contribute to offspring's medical problems

A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, "Age-related methylation changes in the human sperm epigenome."

21 Mar 2023

AI-based design method synthesizes polymers that mimic blood plasma

Most life on Earth is based on polymers of 20 amino acids that have evolved into hundreds of thousands of different, highly specialized proteins. They catalyze reactions, form backbone and muscle and even generate movement.

20 Mar 2023

Using unsupervised machine learning algorithms to classify osteosarcoma

A new editorial paper was published in Oncotarget's Volume 14 on February 11, 2023, entitled, "Unlocking the potential of molecular-driven stratification for osteosarcoma treatment and prognosis."

20 Mar 2023

Novel RNA sense-and-respond circuit harnesses the force of enzymes to develop better drugs

More than twelve billion doses of mRNA vaccines have been administered globally since the start of the COVID pandemic, saving millions of lives. But RNA-based therapies for other diseases have so far proven more challenging to develop.

20 Mar 2023

Decreased viral infection severity in females may be due to extra copy of X chromosome-linked gene

It has long been known that viral infections can be more severe in males than females, but the question as to why has remained a mystery – until possibly now.

17 Mar 2023

Study reveals the underlying mechanism by which TKI cancer drugs cause inflammation

Tyrosine kinase inhibitors are a type of targeted cancer medicine that can attack specific types of cancer cells and prevent them from multiplying.

17 Mar 2023

How the structural and functional effects of mutations on androgen receptor lead to prostate cancer

The androgen receptor is a key transcriptional factor for the proper sex development —specially in males— and the physiological balance of all the tissues that express this receptor.

17 Mar 2023

Structure of cellular shredders varies according to cell type, study shows

"Miniature shredders" are at work in each cell, disassembling and recycling cell components that are defective or no longer required.

16 Mar 2023

Chemists reveal a whole new role for molecular mirroring

With the aid of some sea slugs, University of Nebraska–Lincoln chemists have discovered that one of the smallest conceivable tweaks to a biomolecule can elicit one of the grandest conceivable consequences: directing the activation of neurons.

15 Mar 2023

Research reveals the modulatory effect of anti-inflammatory metabolite on immune cells

Researchers have revealed the modulatory effect of the anti-inflammatory metabolite itaconate on T helper and T regulatory cells, which may lead to new therapeutic approaches to treating some autoimmune diseases.

15 Mar 2023

Reversing infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein

Houston Methodist scientists reversed infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein, showing further evidence that links high cholesterol to female infertility.

15 Mar 2023

Study paves way for developing effective ASO therapies for brain diseases with fewer side effects

A promising therapy for a range of brain diseases involves antisense oligonucleotides (ASOs) - specialized molecules that can modulate RNA and alter protein production - directly injected into the cerebrospinal fluid, in the space around the brain and spinal cord.

14 Mar 2023

Molecular & Structural Biology

Genes known to control eye color are essential for retinal health

New way to safely, sustainably synthesize a molecule with remarkable anticancer properties

Modulating the function of immune cells to recover aging muscle's regenerative capacity

Study outlines a meta-scale approach to quantifying the human proteome

Understanding the structure of CFTR could help design more effective therapies for cystic fibrosis

Study discovers a protein controlling resistance to chemotherapy

Researchers discover how a single mechanosensitive protein induces fibrosis

New insights into how the brain's 'internal compass' works

Age-induced methylation changes in the sperm epigenome contribute to offspring's medical problems

AI-based design method synthesizes polymers that mimic blood plasma

Using unsupervised machine learning algorithms to classify osteosarcoma

Novel RNA sense-and-respond circuit harnesses the force of enzymes to develop better drugs

Decreased viral infection severity in females may be due to extra copy of X chromosome-linked gene

Study reveals the underlying mechanism by which TKI cancer drugs cause inflammation

How the structural and functional effects of mutations on androgen receptor lead to prostate cancer

Structure of cellular shredders varies according to cell type, study shows

Chemists reveal a whole new role for molecular mirroring

Research reveals the modulatory effect of anti-inflammatory metabolite on immune cells

Reversing infertility in sterile mice by reducing high-circulating cholesterol with a bacterial protein

Study paves way for developing effective ASO therapies for brain diseases with fewer side effects

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