Molecular & Structural Biology

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Electrochemical method helps to continuously witness and analyze details of protein folding

Scientists are not yet clear on how the tau protein changes from a benign protein essential for normal function in our brains into the toxic neurofibrillary tangles that are a signature of Alzheimer's and other neurodegenerative diseases.

15 Feb 2023

Scientists reach a substantial consensus on the four principles that will enable the future development and expansion of virus taxonomy

A team of 45 virologists, evolutionary biologists, bioinformaticians, and structural biologists from around the world arrived at a consensus on virus classification methodologies and presented an integrated taxonomical framework for the systematics and taxonomy of viruses.

15 Feb 2023

New insights into the role of T-cells during long COVID

Researchers characterize the trajectory of long COVID in patients eight months after recovering from infection.

14 Feb 2023

Drug treatment in adulthood can counteract the behavioral abnormalities typical of autism

The behavioral disorders observed in autism are associated with a multitude of genetic alterations. Scientists from the Hector Institute for Translational Brain Research (HITBR) have now found another molecular cause for this condition.

14 Feb 2023

UT Southwestern researchers map gene control elements responsible for coordinating heartbeats

UT Southwestern Medical Center researchers have mapped gene control elements in specialized cardiac cells responsible for coordinating heartbeats.

13 Feb 2023

β-damascone can function as an efficient modulator of dendritic cell-mediated functions

Dendritic cells (DCs) are important players of the immune system with important functions such as the identification of infectious pathogens, production of cytokines (chemical signalers of the immune system), presentation of antigens to activate T-cells, and more.

10 Feb 2023

Molecular switch regulates autophagy in plants

Autophagy, or "self-eating", is an essential cellular quality control mechanism that clears the cell of protein aggregates and damaged organelles. This mechanism is inactive under normal conditions and only triggered upon persistent cellular stress.

10 Feb 2023

New method for capturing moments during protein translation

Nascent polypeptide chains or polypeptidyl-tRNAs (pep-tRNAs) occur transiently during protein synthesis. The potential to study these intermediates and better understand their role in processes like gene regulation has been greatly enhanced by the development of a process termed PETEOS—short for peptidyl-tRNA enrichment using organic extraction and silica adsorption.

10 Feb 2023

3D architecture ofAedes aegypti’s chromosomes may offer clues on gene expression, regulation

When it comes to DNA, one pesky mosquito turns out to be a rebel among species.

9 Feb 2023

Researchers discover small molecules that can lock SARS-CoV-2 spike proteins

The infamous spike proteins on the surface of SARS-CoV-2 help it bind to and enter human cells. Because of their important role in spreading infection, these spike proteins are one of the main targets for COVID-19 vaccines and treatments.

9 Feb 2023

Macrophages suppress Escherichia coli LF82 Gally prophage lytic cycle

Researchers analyze prophages of the LF82 strain of adherent-invasive Escherichia coli to better understand their behavior in vitro and within macrophages.

8 Feb 2023

Study reveals some of the fundamental biology of p97 protein in neurodegenerative disease

The p97 protein is one of your body's best garbage disposers. It floats around in your cells looking for signals that a protein is past its shelf life and needs to be trashed.

7 Feb 2023

Integrated NGS system can deliver accurate, genomics-based diagnoses to accelerate treatment for myeloid neoplasms

Identifying recurrent genetic alterations in myeloid neoplasms has improved diagnosis and expanded targeted treatments available to patients. However, treatment initiation can be delayed by the variable and lengthy turnaround times involved in testing for these alterations.

7 Feb 2023

High-fat diet allows the immune system to eliminate a parasitic worm from the intestine

Scientists have discovered that a high-fat diet allows the immune system to eliminate a parasitic worm which is a major cause of death and illness in the developing world.

7 Feb 2023

Cancer-causing viruses use a human protein to evade the innate immune response

The viruses Kaposi sarcoma-associated herpesvirus (KSHV) and Epstein-Barr virus (EBV) have been linked to several cancers.

6 Feb 2023

Cryo-EM provides new insights into the structure of the centromeric region

The genetic material inside cells is organized into structures called chromosomes. The centromere is essential for the correct division of the chromosomes via interaction with spindle microtubules when cells divide and grow.

6 Feb 2023

Researchers discover how a protein deficiency can prepare the brain to minimize damage after stress

Astrocytes, small star-shaped cells, play an important role in signal transmission in the brain. Since the protein Ezrin is found abundantly in astrocyte tendrils, it is presumed to play a role in brain function.

3 Feb 2023

UT Southwestern research could lead to new ways of controlling gene regulation

UT Southwestern Medical Center researchers have discovered a method cells use to turn genes on and off that involves portions of proteins whose function has long been a mystery.

3 Feb 2023

Breakthrough technology identifies rare brain tumor cell "spies" disguised as normal cells

Researchers at the Hong Kong University of Science and Technology developed a novel technology which allows genomic DNA and RNA sequencing to be carried out simultaneously in single cells of both frozen and fresh tissues, and identified rare brain tumor cell "spies" disguised as normal cells with this method.

3 Feb 2023

Deletion of a tumor suppressor gene promotes luminal breast cancer development and resistance to endocrine therapy

A research team from LKS Faculty of Medicine, the University of Hong Kong (HKUMed) discovered that somatic deletion of a tumor suppressor gene AKTIP promotes luminal breast cancer development and resistance to endocrine therapy.

3 Feb 2023

Molecular & Structural Biology

Electrochemical method helps to continuously witness and analyze details of protein folding

Scientists reach a substantial consensus on the four principles that will enable the future development and expansion of virus taxonomy

New insights into the role of T-cells during long COVID

Drug treatment in adulthood can counteract the behavioral abnormalities typical of autism

UT Southwestern researchers map gene control elements responsible for coordinating heartbeats

β-damascone can function as an efficient modulator of dendritic cell-mediated functions

Molecular switch regulates autophagy in plants

New method for capturing moments during protein translation

3D architecture ofAedes aegypti’s chromosomes may offer clues on gene expression, regulation

Researchers discover small molecules that can lock SARS-CoV-2 spike proteins

Macrophages suppress Escherichia coli LF82 Gally prophage lytic cycle

Study reveals some of the fundamental biology of p97 protein in neurodegenerative disease

Integrated NGS system can deliver accurate, genomics-based diagnoses to accelerate treatment for myeloid neoplasms

High-fat diet allows the immune system to eliminate a parasitic worm from the intestine

Cancer-causing viruses use a human protein to evade the innate immune response

Cryo-EM provides new insights into the structure of the centromeric region

Researchers discover how a protein deficiency can prepare the brain to minimize damage after stress

UT Southwestern research could lead to new ways of controlling gene regulation

Breakthrough technology identifies rare brain tumor cell "spies" disguised as normal cells

Deletion of a tumor suppressor gene promotes luminal breast cancer development and resistance to endocrine therapy

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