Molecular & Structural Biology

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Researchers discover new transporter used by some bacteria to recycle cell wall fragments

A transporter which some bacteria use to recycle fragments of their cell wall has been discovered by researchers at Umeå university, Sweden.

26 Jan 2023

Scientists use next-generation protein degradation technology to study CTCF's role in transcription

CTCF is a critical protein known to play various roles in key biological processes such as transcription. Scientists at St. Jude Children's Research Hospital used a next-generation protein degradation technology to study CTCF.

26 Jan 2023

Researchers gain systematic insight into the organization of proteins in mitochondria

Mitochondria, the so-called powerhouse of the cells, are responsible for the energy supply of the organism and fulfill functions in metabolic and signaling processes.

25 Jan 2023

Altered amino acid metabolism could contribute to diabetes-associated peripheral neuropathy

Approximately half of people with type 1 or type 2 diabetes experience peripheral neuropathy - weakness, numbness, and pain, primarily in the hands and feet.

25 Jan 2023

New method analyzes long-range interactions in the interactome

Researchers at the Josep Carreras Leukaemia Research Institute have developed a method to analyze long-range interactions in the DNA -the interactome- from a very low amount of starting material.

25 Jan 2023

Breathing and tilting motions of influenza glycoproteins could be exploited to better defend against flu

The potential "tripledemic" of influenza, SARS-CoV-2 and RSV (respiratory syncytial virus) infection continues to be a concern.

25 Jan 2023

Cryo-electron microscopy reveals detailed blueprint of viral genome replication machinery

RNA viruses, such as the coronavirus that causes COVID-19, are in a life-and-death race the moment they infect a cell.

25 Jan 2023

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Cells zealously protect the integrity of their genomes, because damage can lead to cancer or cell death. The genome - a cell's complete set of DNA - is most vulnerable while it is being duplicated before a cell divides. Cancer cells constantly are dividing, so their genomes are constantly in jeopardy.

24 Jan 2023

Neurons in a bow-shaped brain region become hyperactive after chronic stress exposure

It's clear that chronic stress can impact our behavior, leading to problems like depression, reduced interest in things that previously brought us pleasure, even PTSD.

24 Jan 2023

Study: 12-hour gene expression rhythms are missing or altered in schizophrenic brains

Researchers at the University of Pittsburgh School of Medicine, U.S. present the first evidence of 12-hour cycles of gene activity in the human brain. Publishing in the open access journal PLOS Biology on January 24th, the study led by Madeline R. Scott also reveals that some of those 12-hour rhythms are missing or altered in the postmortem brains of patients with schizophrenia.

24 Jan 2023

Study uncovers protein that acts as a brake for DNA replication

A protein that prepares DNA for replication also prevents the replication process from running out of control, according to a new study by Weill Cornell Medicine researchers.

24 Jan 2023

Novel amyloid protein discovered from canine mammary tumors

A collaboration led by scientists at Tokyo University of Agriculture and Technology (TUAT), Japan, has discovered a novel amyloid protein from canine mammary tumors.

24 Jan 2023

Cryo-electron microscopy captures the first 3D structure of SPOP protein that drives cancer

SPOP is the most mutated protein in prostate cancer and plays a role in endometrial, uterine and other cancers. Despite this importance, how SPOP mutations drive cancer has been incompletely understood.

23 Jan 2023

New tool can accurately discover, quantify RNA molecules from error-prone long-read RNA sequencing data

On the journey from gene to protein, a nascent RNA molecule can be cut and joined, or spliced, in different ways before being translated into a protein.

20 Jan 2023

Study reveals the mechanism through which Sirtuin 7 protein suppresses thermogenesis in mice

Mammals convert the energy stored in adipose (fat) tissue into heat via a process known as thermogenesis.

20 Jan 2023

First-ever computer reconstruction replicates the exact chemical and 3D structure of a 'live' virus

An Aston University researcher has created the first ever computer reconstruction of a virus, including its complete native genome.

20 Jan 2023

New drug target for Ewing sarcoma discovered

Scientists at Cold Spring Harbor Laboratory (CSHL) have discovered a new drug target for Ewing sarcoma, a rare kind of cancer usually diagnosed in children and young adults.

20 Jan 2023

HKUST researchers map out the fundamental mechanisms of C.elegans Microprocessor

The study of microRNAs (miRNAs), small RNAs that play important roles in gene regulation in animals and humans alike, have long been a topic of interest to many.

19 Jan 2023

Research provides a comprehensive structural framework to design safer pain-relieving drugs

In the continuing effort to improve upon opioid pain relievers, American and Chinese scientists used cryoEM technology to solve the detailed structures of the entire family of opioid receptors bound to their naturally occurring peptides.

18 Jan 2023

Study explores the role of endocannabinoids in hazardous drinking among young adults

Although heavy drinking in young adulthood increases the risk for alcohol use disorder (AUD), not all young heavy drinkers go on to develop AUD, globally the most common substance use disorder.

18 Jan 2023

Molecular & Structural Biology

Researchers discover new transporter used by some bacteria to recycle cell wall fragments

Scientists use next-generation protein degradation technology to study CTCF's role in transcription

Researchers gain systematic insight into the organization of proteins in mitochondria

Altered amino acid metabolism could contribute to diabetes-associated peripheral neuropathy

New method analyzes long-range interactions in the interactome

Breathing and tilting motions of influenza glycoproteins could be exploited to better defend against flu

Cryo-electron microscopy reveals detailed blueprint of viral genome replication machinery

Targeting newly discovered signaling pathway could boost the potency of cancer therapeutics

Neurons in a bow-shaped brain region become hyperactive after chronic stress exposure

Study: 12-hour gene expression rhythms are missing or altered in schizophrenic brains

Study uncovers protein that acts as a brake for DNA replication

Novel amyloid protein discovered from canine mammary tumors

Cryo-electron microscopy captures the first 3D structure of SPOP protein that drives cancer

New tool can accurately discover, quantify RNA molecules from error-prone long-read RNA sequencing data

Study reveals the mechanism through which Sirtuin 7 protein suppresses thermogenesis in mice

First-ever computer reconstruction replicates the exact chemical and 3D structure of a 'live' virus

New drug target for Ewing sarcoma discovered

HKUST researchers map out the fundamental mechanisms of C.elegans Microprocessor

Research provides a comprehensive structural framework to design safer pain-relieving drugs

Study explores the role of endocannabinoids in hazardous drinking among young adults

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