Molecular & Structural Biology

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New guidelines for designing synthetic molecules that block interaction between two proteins

Inside cells, proteins constantly interact with each other to carry out different functions. For some diseases in which these functions are altered, blocking the binding between two or more proteins emerges as a possible therapeutic approach.

30 Nov 2022

CSU engineers introduce a better way to perform mosquito-tracking for disease applications

West Nile, Zika, dengue and malaria are all diseases spread by bites from infected mosquitoes. To track the threat of such diseases over large populations, scientists need to know where the mosquitoes are, where they've been, and where they might go.

30 Nov 2022

Powerful imaging tool creates 3D atlas of the spectrum of tuberculous and COVID-19 lung lesions

Gross anatomy reveals three-dimensional shapes of pathology at a large scale. Histology, in contrast, reveals the microscopic anatomy of biological structures. But that magnification comes at a cost -; histology shows only two-dimensional shapes because it studies small, flat slices of stained tissue.

29 Nov 2022

MicroRNAs play a key role in the development of complex brains

Cephalopods like octopuses, squids and cuttlefish are highly intelligent animals with complex nervous systems.

25 Nov 2022

Pocket feature in SARS-CoV-2 spike protein is present in all deadly coronaviruses, study reveals

Scientists have discovered why some coronaviruses are more likely to cause severe disease, which has remained a mystery, until now.

24 Nov 2022

Research reveals existence of a hidden ''pocket’ on the surface of key SARS-CoV-2 protein

With the continuous emergence of new variants and the risk of new strains of the virus, the development of innovative therapies against SARS-CoV-2 remains a major public health challenge.

23 Nov 2022

MYC proteins form hollow spheres that shield the genome of cancer cells

MYC genes and their proteins play a central role in the emergence and development of almost all cancers. They drive the uncontrolled growth and altered metabolism of tumour cells. And they help tumours hide from the immune system.

23 Nov 2022

Study reveals structural insights into the elusive tankyrase protein that fuels bowel cancer

Scientists have revealed the inner workings of a key protein involved in a wide range of cellular processes – potentially paving the way for better and less toxic cancer drugs.

23 Nov 2022

Researchers make an incredible discovery about mammalian brains

In a new breakthrough to understand more about the mammalian brain, University of Copenhagen researchers have made an incredible discovery.

23 Nov 2022

A simple method to prepare carbon isotope-labeled versions of drugs and diagnostics

Dr. Benjamin Rotstein and collaborators unveil an operationally simple method to prepare carbon isotope-labeled versions of drugs and diagnostics.

22 Nov 2022

New family of adeno-associated viral vectors found to be better at delivering genetic cargo

Gene therapies can treat, even potentially cure, certain genetic diseases, but it is challenging to deliver the treatments to the parts of the body where they are needed.

22 Nov 2022

Unique resource for identifying new biomarkers of environmental exposures in early life

Researchers now have a unique resource for identifying new biomarkers of environmental exposures in early life and understanding their health effects.

22 Nov 2022

Scientists develop RNA-targeting strategy to repair genetic cause of ALS and dementia

Scientists at UF Scripps Biomedical Research have developed a potential medicine for a leading cause of ALS and dementia that works by eliminating disease-causing segments of RNA. The

22 Nov 2022

Gene mutation associated with autism causes an overstimulation of brain cells

Scientists looking to understand the fundamental brain mechanisms of autism spectrum disorder have found that a gene mutation known to be associated with the disorder causes an overstimulation of brain cells far greater than that seen in neuronal cells without the mutation.

21 Nov 2022

Molecular motion of many 'undruggable' proteins reveals previously unseen binding sites

Studying the molecular motion of proteins reveals previously unseen binding sites that could be targeted by new drug candidate molecules.

21 Nov 2022

Genetic background plays a role in regulating the metabolism of essential polyunsaturated fatty acids

Genetic background has an effect on the metabolism of the essential polyunsaturated fatty acids alpha-linolenic acid and linoleic acid, a recent study from the University of Eastern Finland shows.

21 Nov 2022

Brain organoids reveal how alcohol exposure impairs the development and functioning of new brain cells

Alcohol consumption during pregnancy poses significant peril to the healthy development of the unborn child. There is no known safe amount of alcohol during pregnancy.

20 Nov 2022

Experts investigate the role of IL-26 in COVID-19

Researchers at Karolinska Institutet in Sweden have shown that patients with acute COVID-19 infection have increased levels of the cytokine IL-26 in their blood. Moreover, high IL-26 levels correlate with an exaggerated inflammatory response that signifies severe cases of the disease. The findings, which are presented in Frontiers in Immunology, indicate that IL-26 is a potential biomarker for severe COVID-19.

17 Nov 2022

SARS-CoV-2 ‘Deltacron’ variant exhibits immune-escape properties similar to Omicron BA.1

The SARS-CoV-2 Deltacron does not exhibit higher transmissibility or immune evasion than the Omicron BA.1 variant.

16 Nov 2022

NIH researchers identify differences in gene activity in the brains of individuals with ADHD

Researchers at the National Institutes of Health have successfully identified differences in gene activity in the brains of people with attention deficit hyperactivity disorder (ADHD).

16 Nov 2022

Molecular & Structural Biology

New guidelines for designing synthetic molecules that block interaction between two proteins

CSU engineers introduce a better way to perform mosquito-tracking for disease applications

Powerful imaging tool creates 3D atlas of the spectrum of tuberculous and COVID-19 lung lesions

MicroRNAs play a key role in the development of complex brains

Pocket feature in SARS-CoV-2 spike protein is present in all deadly coronaviruses, study reveals

Research reveals existence of a hidden ''pocket’ on the surface of key SARS-CoV-2 protein

MYC proteins form hollow spheres that shield the genome of cancer cells

Study reveals structural insights into the elusive tankyrase protein that fuels bowel cancer

Researchers make an incredible discovery about mammalian brains

A simple method to prepare carbon isotope-labeled versions of drugs and diagnostics

New family of adeno-associated viral vectors found to be better at delivering genetic cargo

Unique resource for identifying new biomarkers of environmental exposures in early life

Scientists develop RNA-targeting strategy to repair genetic cause of ALS and dementia

Gene mutation associated with autism causes an overstimulation of brain cells

Molecular motion of many 'undruggable' proteins reveals previously unseen binding sites

Genetic background plays a role in regulating the metabolism of essential polyunsaturated fatty acids

Brain organoids reveal how alcohol exposure impairs the development and functioning of new brain cells

Experts investigate the role of IL-26 in COVID-19

SARS-CoV-2 ‘Deltacron’ variant exhibits immune-escape properties similar to Omicron BA.1

NIH researchers identify differences in gene activity in the brains of individuals with ADHD

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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