Molecular & Structural Biology

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Researchers conduct experiments comparing de novo proteins with computer-generated proteins

Proteins are components of every cell. How they have changed in the course of evolution for the purpose of taking on new functions in the body, has long been a subject of research.

12 Apr 2023

UC-led research team receives NIH grant to study the role of an enzyme in lysosome function

Once thought of as having one simple job within cells, researchers continue to learn more about the importance of organelles called lysosomes.

11 Apr 2023

3D structure of a probable precursor to the CRISPR-Cas12 enzyme revealed

Gene editing is one of the latest breakthroughs in biology. The widely known CRISPR-Cas gene editing system provided prokaryotes (organisms that lack cell nuclei) an immunity against foreign DNA. Since the discovery of the CRISPR gene editing technology, scientists are revealing the evolution of the CRISPR-Cas proteins from their precursors.

7 Apr 2023

Highly complementary, biologically relevant protein-protein interactions can evolve entirely by chance

Proteins are the key players for virtually all molecular processes within the cell. To fulfil their diverse functions, they have to interact with other proteins.

7 Apr 2023

Parkinson's linked to higher levels of pheomelanin in brain: Could it be a biomarker or treatment target?

Researchers discover that the substantia nigra of individuals with Parkinson’s disease had a higher concentration of pheomelanin.

6 Apr 2023

SFU researchers study pathogen genes to develop new drugs against bacterial infections

Researchers at Simon Fraser University are studying the genes of superbugs to aid the development of new and effective treatments for drug-resistant bacterial infections.

5 Apr 2023

Naturally produced molecule directly targets and keeps Fusobacteria under control

Researchers at the Forsyth Institute have discovered an important mechanism that may have profound implications for how we prevent colorectal cancer. Oddly enough, their discovery began in the mouth.

5 Apr 2023

N-abling the acceleration of the life sciences through precision dispensing

In this interview, we speak to Holger Eickhoff, CEO and Founder of Scienion, about their latest technology, The Nucleus Automation Ecosystem.

From SCIENION GmbH 4 Apr 2023

Tighter core of SARS-CoV-2 spike protein in new variants may have increased the virus's fitness

Just as a tight core is a component of good physical fitness for humans, helping to stabilize our bodies, mutations that tightened the core of the SARS-CoV-2 spike protein in new variants may have increased the virus's fitness.

31 Mar 2023

Researchers report surprising first steps that promote resistance to commonly prescribed antibiotics

Antibiotic resistance is a global health threat. In 2019 alone, an estimated 1.3 million deaths were attributed to antibiotic resistant bacterial infections worldwide.

31 Mar 2023

Developing lipid nanoparticles to carry mRNA specifically to the pancreas

Therapeutics that use mRNA - like some of the COVID-19 vaccines - have enormous potential for the prevention and treatment of many diseases.

31 Mar 2023

New model of DNA flexibility opens up the possibility of getting closer to the chromatin scale

In both physics and chemistry, the mesoscopic scale refers to the length scale on which the properties of a material or phenomenon can be studied, without entering into a discussion about the behavior of individual atoms.

31 Mar 2023

Researchers develop a biosensor for real time detection of the G-protein molecular switch

DGIST (President: Kook Yang) announced on March 16th that the research team led by Professor Byung-Chang Suh has investigated for the first time the real-time effect of the G-protein cycle, which acts as a switch in our body, on the structural changes in G protein-coupled receptors (GPCRs).

31 Mar 2023

New structural details of the COVID-19 virus revealed

A new study led by Worcester Polytechnic Institute (WPI) brings into sharper focus the structural details of the COVID-19 virus, revealing an elliptical shape that "breathes," or changes shape, as it moves in the body.

30 Mar 2023

New model captures the complex shapes and biophysical properties of neurons

The thalamus and thalamic reticular nucleus are situated at the heart of the mammalian brain and are known to play a key role in a wide range of functions, including the transmission of sensory information to the cortex and the transition between brain states such as sleep and wakefulness.

30 Mar 2023

Riboswitch may be the key to advance gene therapy, regenerative medicine

The Okinawa Institute of Science and Technology, in collaboration with Astellas Pharma Inc., has developed a new toolkit that uses small molecules to control the activity of a piece of synthetic RNA, and ultimately regulate gene expression.

30 Mar 2023

The origin of congenital coronary fistulae discovered

Scientists of the Department of Animal Biology of the University of Malaga have discovered the cellular mechanism that originates coronary arterio-ventricular fistulae, a congenital anomaly that, in severe cases, may result in death.

30 Mar 2023

Cellular senescence and extracellular vesicles partner to play a role in triggering amyloidosis

A new editorial paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, "Senescence and extracellular vesicles: novel partners in vascular amyloidosis."

29 Mar 2023

Advancements and challenges of constructing artificial mitochondria and chloroplasts

Energy production in nature is the responsibility of chloroplasts and mitochondria and is crucial for fabricating sustainable, synthetic cells in the lab.

28 Mar 2023

Newly designed molecule disrupts the infection mechanism of SARS-CoV-2

A team of scientists led by the Department of Energy's Oak Ridge National Laboratory designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.

28 Mar 2023

Molecular & Structural Biology

Researchers conduct experiments comparing de novo proteins with computer-generated proteins

UC-led research team receives NIH grant to study the role of an enzyme in lysosome function

3D structure of a probable precursor to the CRISPR-Cas12 enzyme revealed

Highly complementary, biologically relevant protein-protein interactions can evolve entirely by chance

Parkinson's linked to higher levels of pheomelanin in brain: Could it be a biomarker or treatment target?

SFU researchers study pathogen genes to develop new drugs against bacterial infections

Naturally produced molecule directly targets and keeps Fusobacteria under control

N-abling the acceleration of the life sciences through precision dispensing

Tighter core of SARS-CoV-2 spike protein in new variants may have increased the virus's fitness

Researchers report surprising first steps that promote resistance to commonly prescribed antibiotics

Developing lipid nanoparticles to carry mRNA specifically to the pancreas

New model of DNA flexibility opens up the possibility of getting closer to the chromatin scale

Researchers develop a biosensor for real time detection of the G-protein molecular switch

New structural details of the COVID-19 virus revealed

New model captures the complex shapes and biophysical properties of neurons

Riboswitch may be the key to advance gene therapy, regenerative medicine

The origin of congenital coronary fistulae discovered

Cellular senescence and extracellular vesicles partner to play a role in triggering amyloidosis

Advancements and challenges of constructing artificial mitochondria and chloroplasts

Newly designed molecule disrupts the infection mechanism of SARS-CoV-2

Redefining control and consistency in anaerobic microbiome workflows

AI in Healthcare: How generative tools are transforming clinical practice

The future of automation: Machine learning–driven hepatocyte and organoid counting

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