Molecular & Structural Biology

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Cryo-EM reveals the structure of hnRNPDL-2 protein fibrils associated with limb-girdle muscular dystrophy

Limb-girdle muscular dystrophy type 3 (LGMD D3) is a rare disease causing progressive muscle weakness, caused by point mutations in the hnRNPDL-2 protein.

3 Feb 2023

Researchers discover a new hexameric structure of the RepB protein and how it binds to DNA

In all living organisms, DNA replication is essential to ensure the genetic fidelity of the next generation. However, bacteria can also transfer genetic information horizontally to other bacteria.

3 Feb 2023

Pulmonary surfactant-mediated inflammatory response against SARS-CoV-2

Researchers discuss the role of a surfactant-mediated inflammatory response employed by human lungs against SARS-CoV-2.

3 Feb 2023

Molnupiravir-related mutational signatures among COVID-19 patients

Researchers explore a mutational signature related to molnupiravir in SARS-CoV-2 sequencing datasets.

3 Feb 2023

Partially quasi-programmed diseases can be delayed by slowing aging

A new research perspective was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 15, Issue 2, entitled, "Are menopause, aging and prostate cancer diseases?"

3 Feb 2023

Improving CAR-based-immunotherapies using a molecular anchor

Adding a molecular anchor to the key protein used to recognize cancer in cellular immunotherapies can make the treatments significantly more effective.

3 Feb 2023

Research project aims to shed new light on how proteins in viruses bind to molecules

The way in which molecules interact forms the basis of life and treating illness. But what does it look like when a viral protein meets and binds to molecules like those found in medications? A new research project has been awarded DKK 65 million by the European Research Council and will now aim to shed light on this hitherto invisible process.

2 Feb 2023

Novel tool uses AI to predict the efficacy of genome-editing repair options

Researchers at the University of Zurich have developed a new tool that uses artificial intelligence to predict the efficacy of various genome-editing repair options.

2 Feb 2023

Microscopic technique enables real-time study of RNA G-quadruplexes in living cells

A new microscopic technique allows for the real-time study of RNA G-quadruplexes in living cells, with implications for the fight against amyotrophic lateral sclerosis.

2 Feb 2023

U of A researcher one step closer to demonstrating the potential of brain molecule to halt MS

A University of Alberta researcher is one step closer to demonstrating the potential of a brain molecule called fractalkine to halt and even reverse the effects of multiple sclerosis and other neurodegenerative diseases.

1 Feb 2023

Light-activated nanoscale drills can combat infectious fungi

That stubborn athlete's foot infection an estimated 70% of people get at some point in their life could become much easier to get rid of thanks to nanoscale drills activated by visible light.

1 Feb 2023

Voice-activated device could make DNA handling at the laboratory safer for scientists

Smart voice assistants are a popular way for people to get quick answers or play their favorite music. That same technology could make the laboratory safer for scientists and technicians who handle potentially infectious samples.

1 Feb 2023

Highly effective detection of cancer biomarkers using CRISPR

Most cancer diagnostic techniques rely on uncomfortable and invasive procedures, such as biopsies, endoscopies or mammograms.

1 Feb 2023

Study solves a 50-year mystery about messenger RNAs

Messenger RNAs (mRNAs) contain chemical marks that are critical for antiviral defense in cells, according to a new study from researchers at Weill Cornell Medicine.

1 Feb 2023

Transcriptomics analysis identifies thousands of viroid-like circular RNA molecules

Metatranscriptomics analysis reveals the existence of over ten thousand viroids and viroid-like RNAs.

1 Feb 2023

A machine-learning approach to identify asthma subtypes based on molecular signatures

Researchers determine whether protein expression in nasal fluid samples could assist in the diagnosis of severe asthma subtypes.

31 Jan 2023

Study opens new therapeutic avenues for treatment of rheumatoid arthritis

A research team, led by Professor Sung Ho Park in the Department of Biological Sciences at UNIST announced the results of a study on osteoblasts that damage joint bones in patients with rheumatoid arthritis.

31 Jan 2023

Cornell research provides new insight into chemotherapy agent's effect on DNA

New Cornell research is providing a fresh view into the ways a common chemotherapy agent, etoposide, stalls and poisons the essential enzymes that allow cancer cells to flourish.

30 Jan 2023

Structure and function of the first FDA-approved treatment for Ebola virus discovered

Scientists at La Jolla Institute for Immunology (LJI) have uncovered the structure and function of the first FDA-approved treatment for Zaire ebolavirus (Ebola virus).

30 Jan 2023

Study focuses on plasticity of the synapses between the hypothalamus and hippocampus

The complexity of the human brain is unparalleled. Fortunately, thanks to constant progress in neuroscience over the past decades, we have started to make some sense of the human brain.

30 Jan 2023

Molecular & Structural Biology

Cryo-EM reveals the structure of hnRNPDL-2 protein fibrils associated with limb-girdle muscular dystrophy

Researchers discover a new hexameric structure of the RepB protein and how it binds to DNA

Pulmonary surfactant-mediated inflammatory response against SARS-CoV-2

Molnupiravir-related mutational signatures among COVID-19 patients

Partially quasi-programmed diseases can be delayed by slowing aging

Improving CAR-based-immunotherapies using a molecular anchor

Research project aims to shed new light on how proteins in viruses bind to molecules

Novel tool uses AI to predict the efficacy of genome-editing repair options

Microscopic technique enables real-time study of RNA G-quadruplexes in living cells

U of A researcher one step closer to demonstrating the potential of brain molecule to halt MS

Light-activated nanoscale drills can combat infectious fungi

Voice-activated device could make DNA handling at the laboratory safer for scientists

Highly effective detection of cancer biomarkers using CRISPR

Study solves a 50-year mystery about messenger RNAs

Transcriptomics analysis identifies thousands of viroid-like circular RNA molecules

A machine-learning approach to identify asthma subtypes based on molecular signatures

Study opens new therapeutic avenues for treatment of rheumatoid arthritis

Cornell research provides new insight into chemotherapy agent's effect on DNA

Structure and function of the first FDA-approved treatment for Ebola virus discovered

Study focuses on plasticity of the synapses between the hypothalamus and hippocampus

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