Molecular & Structural Biology

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Lab experiments add further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19's viral pathogenesis - a theory that was posited two years ago by a team of researchers at the Department of Energy's Oak Ridge National Laboratory.

16 Sep 2022

Machine learning can help create proteins much more accurately, quickly than previously possible

Over the past two years, machine learning has revolutionized protein structure prediction. Now, three papers in Science describe a similar revolution in protein design.

15 Sep 2022

Study investigates link between plasma miRNAs and cognitive function among cognitively normal men

A new research paper was published on the cover of Aging (listed as "Aging (Albany NY)" by Medline/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 17, entitled, "Extracellular microRNA and cognitive function in a prospective cohort of older men: The Veterans Affairs Normative Aging Study."

15 Sep 2022

Scientists unravel the molecular origin of rare genetic disease cystinosis

The rare genetic disease cystinosis is caused by mutations in the gene for a protein called cystinosin. A team of scientists has now solved the structure of cystinosin and determined how mutations interfere with its normal function, providing insights into the underlying mechanisms and suggesting a way to develop new treatments for the disease.

15 Sep 2022

Understanding what happens when two gut microbiomes clash together

Fecal microbiota transplantation (FMT) – the transfer of lower intestinal fluids and microbes from one individual to another – is sometimes used to treat inflammatory gut diseases, including ulcerative colitis and bacterial infections.

15 Sep 2022

Defensosomes versus COVID-19

In a recent study published in the journal PLoS Biology, researchers investigated the role of angiotensin-converting enzyme 2 (ACE2)-containing defensive exosomes, or 'defensosomes' against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections.

14 Sep 2022

Large molecules glom together into dense droplets to create squishy circuits in cells

An emerging field explores how groups of molecules condense together inside cells, the way oil droplets assemble and separate from water in a vinaigrette.

14 Sep 2022

MIT researchers use new technique to gather insight into repetitive protein sequences

About 70 percent of all human proteins include at least one sequence consisting of a single amino acid repeated many times, with a few other amino acids sprinkled in. These "low-complexity regions" are also found in most other organisms.

13 Sep 2022

Researchers uncover the structure of protein fibrils linked to hereditary form of human prion disease

In a new study, researchers from the Case Western Reserve University School of Medicine have identified the structure of protein fibrils linked to a hereditary form of human prion disease.

12 Sep 2022

Neuroscientists reveal precise connections between retinal nerve cells and the midbrain structure

For the first time, neuroscientists from Charité – Universitätsmedizin Berlin and the Max Planck Institute for Biological Intelligence (currently in the process of being established) have revealed the precise connections between sensory neurons inside the retina and the superior colliculus, a structure in the midbrain.

12 Sep 2022

Jumping gene plays an important role in reducing depression, fear, and anxiety

First characterized in Prof. Tadashi Yamamoto's former lab in Japan in 1996, the gene Tob is well known for the role it plays in cancer. Previous research has also indicated that it has a hand in regulating the cell cycle and the body's immune response.

9 Sep 2022

Label-free trace detection of bio-molecules by LI-SERS method

A new publication from Opto-Electronic Advances; DOI 10.29026/oea.2022.210121 discusses label-free trace detection of bio-molecules by liquid-interface assisted surface-enhanced Raman scattering using a microfluidic chip.

9 Sep 2022

Molecular probes can track the progress of protein that misbehaves in neurodegenerative diseases

A team of researchers from the IIT-Istituto Italiano di Tecnologia (Italian Institute of Technology) has designed in silico "molecular probes" able to track the progress of a protein that misbehaves in different neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS) and Fronto-Temporal Dementia (FTD).

9 Sep 2022

Understanding the molecular pathways that underly nutrient switch in starving cancer cells

Cancer cells often grow in environments that are low in nutrients, and they cope with this challenge by switching their metabolism to using proteins as alternative "food".

9 Sep 2022

Researchers produce high-resolution crystal structure of enzyme critical to SARS-CoV-2 survival

A team of Mount Sinai researchers has produced a high-resolution crystal structure of an enzyme essential to the survival of SARS-CoV-2, the virus that causes COVID-19.

9 Sep 2022

Scientists observe how SARS-CoV-2 protein dismantles critical immunity pathway

Over the past two years, scientists have studied the SARS-CoV-2 virus in great detail, laying the foundation for developing COVID-19 vaccines and antiviral treatments.

9 Sep 2022

Promising anti-cancer agent may also prevent SARS-CoV-2 from replication

Based on findings from a new study by a Johns Hopkins Medicine-led research team, an effective means of fighting SARS-CoV-2, the virus that causes COVID-19, may be possible that circumvents the problem of waning immunity often observed when current vaccines deal with emerging COVID variants.

8 Sep 2022

Insights into molecular structure of protein assembly that plays key role in controlling cristae architecture

Energy supply is a vital component of economic life. And the complex interplay between society and economy is jeopardized whenever core services or key industrial sectors are at risk of failing because of energy supply problems.

7 Sep 2022

Study helps reveal the molecular secrets of macular degeneration

Research led by Sanford Burnham Prebys professor Francesca Marassi, Ph.D., is helping to reveal the molecular secrets of macular degeneration, which causes almost 90% of all age-related vision loss.

7 Sep 2022

Clock gene-dependent glutamate signaling responsible for seasonal regulation of reproduction in bean bugs

Did you know that not only does organism's body have a biological clock that can tell the time of the day, it can also tell the time of the year? Now, researchers from Japan have found that one capable little molecule may be behind the mechanism by which the biological clock keeps track of the seasons.

6 Sep 2022

Molecular & Structural Biology

Lab experiments add further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis

Machine learning can help create proteins much more accurately, quickly than previously possible

Study investigates link between plasma miRNAs and cognitive function among cognitively normal men

Scientists unravel the molecular origin of rare genetic disease cystinosis

Understanding what happens when two gut microbiomes clash together

Defensosomes versus COVID-19

Large molecules glom together into dense droplets to create squishy circuits in cells

MIT researchers use new technique to gather insight into repetitive protein sequences

Researchers uncover the structure of protein fibrils linked to hereditary form of human prion disease

Neuroscientists reveal precise connections between retinal nerve cells and the midbrain structure

Jumping gene plays an important role in reducing depression, fear, and anxiety

Label-free trace detection of bio-molecules by LI-SERS method

Molecular probes can track the progress of protein that misbehaves in neurodegenerative diseases

Understanding the molecular pathways that underly nutrient switch in starving cancer cells

Researchers produce high-resolution crystal structure of enzyme critical to SARS-CoV-2 survival

Scientists observe how SARS-CoV-2 protein dismantles critical immunity pathway

Promising anti-cancer agent may also prevent SARS-CoV-2 from replication

Insights into molecular structure of protein assembly that plays key role in controlling cristae architecture

Study helps reveal the molecular secrets of macular degeneration

Clock gene-dependent glutamate signaling responsible for seasonal regulation of reproduction in bean bugs

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