Molecular & Structural Biology

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A class of protein-cleaving enzymes suspected to play a role in hereditary brain disease

Similar to Alzheimer's disease, the hereditary disease spinocerebellar ataxia type 17 (SCA17) leads to the destruction of brain nerve cells and the premature death of patients.

21 Jun 2022

Study offers new insight into the growth of blood vessels

Blood vessels must adapt their growth to the nutrients available in their surroundings so that they can keep organs adequately supplied. A team led by Michael Potente has identified two proteins that are important for this process and published their findings in Nature Metabolism.

20 Jun 2022

Proteins in liquor could provide information about inflammatory processes in the brain

Alzheimer's, Parkinson's and other neurodegenerative diseases are associated with inflammatory processes in the brain.

20 Jun 2022

Research may open door to the design of a better structured rabies vaccine

Rabies virus kills a shocking 59,000 people each year, many of them children. Some victims, especially kids, don't realize they've been exposed until it is too late.

17 Jun 2022

Researchers uncover how dopamine in the cerebellum modulates social behaviors

The cerebellum is essential for sensorimotor control but also contributes to higher cognitive functions including social behaviors.

16 Jun 2022

Chemical synthesis, properties, and molecular modeling studies of spiro-indole compounds

In a recent study under review at the Scientific Reports journal and currently posted to the Research Square* preprint server, researchers synthesized and evaluated the antitumoral (against several cancer cell lines) and antiviral [against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)] properties of 3-spiro-indolin-2-ones.

15 Jun 2022

SARS-CoV-2 damages cilia

Researchers determine whether the interaction between ORF10 and ZYG11B promotes the dissemination of SARS-CoV-2.

15 Jun 2022

AKT inhibitor miransertib could be a promising new treatment against low-flow vascular malformations

A team of researchers led by Dr. Sandra Castillo and Dr. Mariona Graupera, from the Josep Carreras Leukaemia Research Institute and member of the CIBERONC, have found the AKT inhibitor miransertib could be a new molecular treatment effective against low-flow vascular malformations, a long-awaited milestone.

14 Jun 2022

Chromosome organization affects evolution of DNA in archaea

The structure of how DNA is stored in archaea makes a significant difference to how quickly it evolves, according to a new study by Indiana University researchers.

14 Jun 2022

Proteomic analysis of 2002 tumors reveals 11 distinct pan-cancer molecular subtypes

A new study that analyzed protein levels in 2,002 primary tumors from 14 tissue-based cancer types identified 11 distinct molecular subtypes, providing systematic knowledge that greatly expands a searchable online database that has become a go-to platform for cancer data analysis by users worldwide.

10 Jun 2022

Deciphering the structure of nuclear pore complex piece by piece

Whatever you are doing, whether it is driving a car, going for a jog, or even at your laziest, eating chips and watching TV on the couch, there is an entire suite of molecular machinery inside each of your cells hard at work.

10 Jun 2022

Cryo-EM helps scientists to decipher the structure of a key part of RNA degradation machinery

In biology, getting rid of stuff can be just as important as making it. A buildup of cells, proteins, or other molecules that are no longer needed can cause problems, so living things have evolved several ways to clean house.

9 Jun 2022

Artificial intelligence-based computational program predicts the 3D structure of rotavirus spike protein

Of the three groups of rotavirus that cause gastroenteritis in people, called groups A, B and C, groups A and C affect mostly children and are the best characterized.

9 Jun 2022

Curia and Replicate Bioscience Enter Strategic Collaboration to Create Groundbreaking Development Platform for Self-Replicating RNA (srRNA)

From Curia 9 Jun 2022

Discovery of small protein’s structure could lead to new therapies for neurological disorders

Scientists have, for the first time, revealed at the atomic level the structure of a protein that carries one of the body's most important neurotransmitters into neurons.

8 Jun 2022

Diet rich in polyphenols can prevent inflammation in the elderly

Polyphenols in the foods that we eat can prevent inflammation in older people, since they alter the intestinal microbiota and induce the production of the indole 3-propionic acid (IPA), a metabolite derived from the degradation of tryptophan due to intestinal bacteria.

8 Jun 2022

Where did Omicron's unique spike gene insertion originate?

In a recent study posted to the medRxiv* pre-print server, scientists at nference Labs investigated the origin of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) new variant of concern (VOC) Omicron's unique spike (S) gene insertion ins214EPE.

8 Jun 2022

Molecular & Structural Biology

A class of protein-cleaving enzymes suspected to play a role in hereditary brain disease

Study offers new insight into the growth of blood vessels

Proteins in liquor could provide information about inflammatory processes in the brain

Research may open door to the design of a better structured rabies vaccine

Researchers uncover how dopamine in the cerebellum modulates social behaviors

Chemical synthesis, properties, and molecular modeling studies of spiro-indole compounds

SARS-CoV-2 damages cilia

AKT inhibitor miransertib could be a promising new treatment against low-flow vascular malformations

Chromosome organization affects evolution of DNA in archaea

Proteomic analysis of 2002 tumors reveals 11 distinct pan-cancer molecular subtypes

Deciphering the structure of nuclear pore complex piece by piece

Cryo-EM helps scientists to decipher the structure of a key part of RNA degradation machinery

Artificial intelligence-based computational program predicts the 3D structure of rotavirus spike protein

Curia and Replicate Bioscience Enter Strategic Collaboration to Create Groundbreaking Development Platform for Self-Replicating RNA (srRNA)

Discovery of small protein’s structure could lead to new therapies for neurological disorders

Diet rich in polyphenols can prevent inflammation in the elderly

Where did Omicron's unique spike gene insertion originate?

Basolateral amygdala may play a larger, overarching role during naturalistic events

MIT researchers identify components of mucus that can inhibit fungal infections

Persistence of viral RNA following acute infection

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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