Molecular & Structural Biology

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Researchers develop universally accessible application that can simulate complex molecular interactions

A team led by University of Minnesota Twin Cities biomedical engineers has developed a universally accessible application that can simulate complex molecular interactions, which will allow researchers to design better treatments for diseases like cancer and COVID-19.

6 Sep 2022

Advances in modeling molecular interactions needed to better harness AlphaFold for drug discovery

Over the past few decades, very few new antibiotics have been developed, largely because current methods for screening potential drugs are prohibitively expensive and time-consuming.

6 Sep 2022

DNA levels of monkeypox correlate with virus infectivity

Scientists test clinical samples of MPXV patients to determine the relationship between the MPXV DNA copies and infectious status.

6 Sep 2022

Discovery of bacteria-killing toxin could pave the way for new generation of antibiotics

Researchers at McMaster University have discovered a previously unknown bacteria-killing toxin that could pave the way for a new generation of antibiotics.

6 Sep 2022

New method can accurately, quickly predict which antigens will lead to strong immune response

A cell's secrets can be divulged by its surface, decorated with tens to hundreds of thousands of molecules that help immune cells determine friend from foe.

5 Sep 2022

UTHSC team wins $2.13 million NINDS award to study early neuron development

The National Institute of Neurological Disorders and Stroke has awarded $2.13 million to a University of Tennessee Health Science Center (UTHSC) team studying how neural cells that build a functional brain are generated during embryonic and neonatal life.

2 Sep 2022

Research reveals a starring role for mitochondrial dynamics within adult muscle stem cells

Mitochondria are remarkable shape-shifting organelles that have long been understood as the powerhouses inside our cells.

2 Sep 2022

Transcriptomic approach reveals shared classes of neuron types in reptilian and mammalian brains

These days, dragons are keeping Game of Thrones fans on their toes. But they are also providing important insights into vertebrate brain evolution, as revealed by the work of Max Planck scientists on the brain of the Australian bearded dragon Pogona vitticeps.

2 Sep 2022

'Rippled beta sheet' protein structure created and characterized using x-ray crystallography

An unusual protein structure known as a "rippled beta sheet," first predicted in 1953, has now been created in the laboratory and characterized in detail using x-ray crystallography.

2 Sep 2022

Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

One of the main challenges in oncology is the development of drugs against KRAS oncogenes. These oncogenes -genes that cause cancer when mutated - are responsible for a quarter of all human cancers, including the three tumor types with the highest mortality rates: lung adenocarcinoma, colorectal carcinoma and pancreatic ductal adenocarcinoma.

1 Sep 2022

Rutgers scientists design a synthetic protein that quickly detects molecules of deadly nerve agent

A team that includes Rutgers scientists has designed a synthetic protein that quickly detects molecules of a deadly nerve agent that has been classified by the United Nations as a weapon of mass destruction and could be used in a chemical warfare attack.

1 Sep 2022

Researchers demonstrate improved culture of primate induced pluripotent stem cells

The following study transplanted iPSCs derived from two NHP species, chimpanzee and pigtailed macaque, into blastocysts from another NHP species – the rhesus macaque.

1 Sep 2022

Food for thought: ventral visual pathway has neural populations that respond very selectively to images of food

In this study, a complete set of human cortical specializations was required that actually reflected the functional organization of the cortex.

31 Aug 2022

Scientists uncover how a build-up of harmful protein starts to happen in Parkinson's disease

Scientists at the Francis Crick Institute, UCL and the University of Edinburgh have uncovered how a build-up of harmful protein starts to happen within neurons in Parkinson's disease, ultimately causing nerve cell death.

30 Aug 2022

Popular genetic method is deeply flawed, study reveals

The most common analytical method within population genetics is deeply flawed, according to a new study from Lund University in Sweden.

30 Aug 2022

In vivo imaging of α-synuclein aggregates in the brains of living patients with multiple system atrophy

α-synuclein is a neuronal protein involved in functions like vesicle trafficking and neurotransmitter release. It is typically found in abundance in a healthy brain.

30 Aug 2022

Vitamin D mediates crosstalk between COVID-19 and osteoporosis

Researchers identify and characterize the targets of Vit D on COVID-19 and osteoporosis.

30 Aug 2022

Researchers create first mouse model carrying a disease-associated mitochondrial mutation

Studying the role of mitochondria—the specialized structures within cells responsible for energy production—in metabolic diseases has been difficult because of a lack of animal models with the necessary mitochondrial mutations to observe these tiny organelles.

30 Aug 2022

Disrupting a virus’s genome packaging can halt replication, study finds

Like savvy international travelers, viruses know exactly how to pack. With the genetic instructions for the next generation folded just so, snuggled into a custom-made outer covering studded with cell-grabbing proteins, these tiny invaders quest for new digs on the reg.

30 Aug 2022

Study reveals a 'stealing' mechanism that contributes to antibody diversity

A few years ago, Professor Kathrin de la Rosa and her colleagues in the lab of the Swiss immunologist Antonio Lanzavecchia made an unusual discovery.

29 Aug 2022

Molecular & Structural Biology

Researchers develop universally accessible application that can simulate complex molecular interactions

Advances in modeling molecular interactions needed to better harness AlphaFold for drug discovery

DNA levels of monkeypox correlate with virus infectivity

Discovery of bacteria-killing toxin could pave the way for new generation of antibiotics

New method can accurately, quickly predict which antigens will lead to strong immune response

UTHSC team wins $2.13 million NINDS award to study early neuron development

Research reveals a starring role for mitochondrial dynamics within adult muscle stem cells

Transcriptomic approach reveals shared classes of neuron types in reptilian and mammalian brains

'Rippled beta sheet' protein structure created and characterized using x-ray crystallography

Study opens a window of opportunity to design RAF1 degraders against lung adenocarcinomas

Rutgers scientists design a synthetic protein that quickly detects molecules of deadly nerve agent

Researchers demonstrate improved culture of primate induced pluripotent stem cells

Food for thought: ventral visual pathway has neural populations that respond very selectively to images of food

Scientists uncover how a build-up of harmful protein starts to happen in Parkinson's disease

Popular genetic method is deeply flawed, study reveals

In vivo imaging of α-synuclein aggregates in the brains of living patients with multiple system atrophy

Vitamin D mediates crosstalk between COVID-19 and osteoporosis

Researchers create first mouse model carrying a disease-associated mitochondrial mutation

Disrupting a virus’s genome packaging can halt replication, study finds

Study reveals a 'stealing' mechanism that contributes to antibody diversity

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