Molecular & Structural Biology

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Scientists develop antibody test to keep track of immunity to SARS-CoV-2 variants

The experts agree -; the pandemic is not over. Infections are ticking up again, fueled by the new variants our immune systems are ill prepared for.

1 Jul 2022

Mosaic-8 RBD-nanoparticles show promise against current and future SARS-CoV-2 variants

A recent study posted to the bioRxiv* preprint server supports using mosaic sarbecovirus receptor-binding domain (RBD)-nanoparticles to discover therapeutic pan-variant and pan-sarbecovirus monoclonal antibodies (mAbs) and to induce mAbs by vaccination.

30 Jun 2022

New study investigates the epigenetic drift of time passing

A new research paper was published in Aging (Aging-US) on the cover of Volume 14, Issue 12, entitled, "Time makes histone H3 modifications drift in mouse liver."

30 Jun 2022

Crystal structure of a human endogenous reverse transcriptase revealed

The crystal structure of a human endogenous reverse transcriptase has similarities to HIV reverse transcriptase, a well-known tractable drug target, which will help design drugs to treat cancer and other diseases, according to a study co-authored by a Rutgers researcher.

30 Jun 2022

Rice lab’s microbial community profiling software effectively identifies bacterial species

Part of a gene is better than none when identifying a species of microbe. But for Rice University computer scientists, part was not nearly enough in their pursuit of a program to identify all the species in a microbiome.

30 Jun 2022

Researchers discover new family of sensing genes in enteric bacteria using AI

Using artificial intelligence, UT Southwestern researchers have discovered a new family of sensing genes in enteric bacteria that are linked by structure and probably function, but not genetic sequence.

30 Jun 2022

Study of condensates offers new hope for the treatment of neurodegenerative diseases

The Körber European Science Prize 2022, endowed with one million euros, is to be awarded to the British cell biologist Anthony Hyman.

30 Jun 2022

Identification of potent SARS-CoV-2 macrodomain inhibitors

A recent study posted to the bioRxiv* preprint server illustrated the optimization of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nonstructural protein 3 (NSP3) macrodomain (Mac) inhibitor based on structure.

30 Jun 2022

SARS-CoV-2 3CLpro also susceptible to mutations

Researchers assess the activity of all potential mutations in the SARS-CoV-2 3CLpro.

29 Jun 2022

Study provides a framework for understanding how tissue-resident memory T cells adapt to distinct environments

Scientists exploring how our immune system responds to pathogens and cancers have ramped up their attention to CD8+ T cells, which are deployed in response to infections and malignancies and equipped to remember the identities of malicious invaders.

29 Jun 2022

Online version of algorithm shows how biases in RNA sequences affect gene expression

A recent publication from researchers at the University of Kentucky explains the importance of identifying and understanding how differences between tissues and cells alter gene expression without changing the underlying genetic code.

29 Jun 2022

Complex molecular dance could inform the development of future treatments for fragile X syndrome

Like many neurological diseases, there's a lot we don't understand about fragile X syndrome. But, after studying the disorder for several years, Lynne Maquat's lab knew two important things: the enzyme AKT, which plays a key role in cell growth and survival, and the quality control pathway known as NMD (nonsense-mediated mRNA decay), are both in overdrive in fragile X.

29 Jun 2022

New machine learning method may improve the identification of genes that cause diseases

A new machine learning method to model gene expression levels might improve the identification of genes that cause human diseases, according to a new study by Penn State College of Medicine researchers.

28 Jun 2022

Study elucidates the molecular mechanisms of acetylcholine for learning and memory

Acetylcholine (ACh) is a neuromodulator with a central role in aversive learning-;rapid conditioning to unpleasant smell, taste, or touch.

28 Jun 2022

Researchers discover a molecular switch that promotes pancreatic cancer metastasis

More than 62,000 people in the United States will be diagnosed with pancreatic cancer by the end of this year, with the vast majority having a deadly and aggressive subtype known as pancreatic ductal adenocarcinoma (PDA).

27 Jun 2022

Chemically modified rocaglates have a stronger effect against viral replication

Hepatitis E virus (HEV) is widespread, and so far there is no effective drug. In the search for one, the so-called rocaglates have come into focus: plant compounds that can inhibit the replication of viruses.

27 Jun 2022

Researchers improve the ability of a protein to repair oxidative DNA damage

Researchers at Karolinska Institutet and SciLifeLab in Sweden describe in a study published in Science how they have improved the ability of a protein to repair oxidative DNA damage and created a new protein function.

23 Jun 2022

Researchers measure temperature-dependent photovoltaic external quantum efficiency to transform the future of solar cells

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From Linkam Scientific Instruments 23 Jun 2022

Gene expression regulation by N6-methyladenosine

A recent study published in Molecular Cell reviewed the control of gene expression by N6-methyladenosine (m6A), a modified nucleotide in the messenger ribonucleic acid (mRNA).

22 Jun 2022

Study shows molecular details of HIV-1 assembly and viral envelope protein incorporation

Assembly of HIV-1, which causes AIDS, takes place on the inner plasma membrane leaflet of infected cells, a geometric building process that creates hexamers out of trimers of the viral Gag protein, as guided by Gag's N-terminal matrix domain.

21 Jun 2022

Molecular & Structural Biology

Scientists develop antibody test to keep track of immunity to SARS-CoV-2 variants

Mosaic-8 RBD-nanoparticles show promise against current and future SARS-CoV-2 variants

New study investigates the epigenetic drift of time passing

Crystal structure of a human endogenous reverse transcriptase revealed

Rice lab’s microbial community profiling software effectively identifies bacterial species

Researchers discover new family of sensing genes in enteric bacteria using AI

Study of condensates offers new hope for the treatment of neurodegenerative diseases

Identification of potent SARS-CoV-2 macrodomain inhibitors

SARS-CoV-2 3CLpro also susceptible to mutations

Study provides a framework for understanding how tissue-resident memory T cells adapt to distinct environments

Online version of algorithm shows how biases in RNA sequences affect gene expression

Complex molecular dance could inform the development of future treatments for fragile X syndrome

New machine learning method may improve the identification of genes that cause diseases

Study elucidates the molecular mechanisms of acetylcholine for learning and memory

Researchers discover a molecular switch that promotes pancreatic cancer metastasis

Chemically modified rocaglates have a stronger effect against viral replication

Researchers improve the ability of a protein to repair oxidative DNA damage

Researchers measure temperature-dependent photovoltaic external quantum efficiency to transform the future of solar cells

Gene expression regulation by N6-methyladenosine

Study shows molecular details of HIV-1 assembly and viral envelope protein incorporation

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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