Molecular & Structural Biology

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Salk scientists identify a protein that is critical for preventing pancreatic auto-digestion in mice

Every day, your pancreas produces about one cup of digestive juices, a mixture of molecules that can break down the food you eat.

21 Apr 2022

Antibodies that neutralize most sarbecoviruses, including SARS-CoV-2 variants

Researchers isolate three mAbs that broadly neutralized sarbecoviruses and carried out virological and structural studies of these mAbs.

21 Apr 2022

New research takes a close look at the most prevalent neurotransmitter in the brain

One of the most important molecules in the brain doesn't work quite the way scientists thought it did, according to new work by researchers at Columbia University Vagelos College of Physicians and Surgeons and Carnegie Mellon University.

21 Apr 2022

CryoEM reveals never-before-seen details of the human androgen receptor

Scientists at Memorial Sloan Kettering Cancer Center (MSK) have glimpsed never-before-seen details of the human androgen receptor - the protein inside of cells that responds to male-typical hormones like testosterone.

20 Apr 2022

Scientists demonstrate a new mechanism by which amino acids curb appetite

Proteins can suppress appetite, so a protein-rich diet can help people lose weight. That's just one of the reasons why this kind of diet has become increasingly popular in recent years.

20 Apr 2022

New deep learning neural network model predicts physical interactions of protein complexes

From the muscle fibers that move us to the enzymes that replicate our DNA, proteins are the molecular machinery that makes life possible.

20 Apr 2022

Using customized 'mini-antibodies' to mitigate chronic inflammation

Researchers at the Universities of Bonn and Sao Paulo have succeeded in mitigating chronic inflammation in mice using customized "mini-antibodies."

19 Apr 2022

Scientists unravel the complex workings of the circadian rhythm in cyanobacteria

Scientists want to increase their understanding of circadian rhythms, those internal 24-hour biological clock cycles of sleeping and waking that occur in organisms, ranging from humans to plants to fungi to bacteria.

18 Apr 2022

Monoclonal antibodies from COVID-19 convalescent donors target conserved site

Researchers found six monoclonal antibodies binding to the spike proteins of all human coronaviruses.

18 Apr 2022

SARS-CoV-2 infection patterns in olfactory epithelium

Researchers assess changes in the respiratory and olfactory epithelium of the nasal mucosa in SARS-CoV-2 infections by the WA1, Delta, and Omicron strains.

18 Apr 2022

SARS-CoV-2 RBD is a selective integrin agonist

Researchers assess the Arg-Gly-Asp (RGD) motif-mediated binding of the SARS-CoV-2 RBD and integrin receptors.

18 Apr 2022

Role of cGAS-STING in SARS-CoV-2 infection

A new study analyzes the activation of cGAS and STING can induce a type I IFN response due to SARS-CoV-2 infection.

15 Apr 2022

Recent advances in non-viral nano-vector delivery of CRISPR/Cas9 genome editing payloads

Researchers reviewed non-viral nano-vectors used for delivering the clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9-mediated genome editing system.

14 Apr 2022

Structural differences between SARS-CoV-1 and SARS-CoV-2 RBDs

A new study compares the SARS-CoV-2 RBD to the SARS-CoV RBD using computational methods to understand their binding affinities to ACE2.

13 Apr 2022

Social connections predict the brain structure of primates

What's the link between social life and brain structure? Researchers from the University of Pennsylvania, the Stem Cell and Brain Research Institute at Inserm, and elsewhere are now one step closer to understanding this connection for rhesus macaques.

13 Apr 2022

The molecular context and substrate profiles of human cell surface receptor tyrosine kinases

researchers discussed and identified the systemic functions and interactions of 52 active cell surface receptor tyrosine kinases, providing insights on RTK-RTK interactions and substrates, RTK-protein complexes, and signaling pathways.

13 Apr 2022

Treg cell Notch receptors drive SARS-CoV-2-induced MIS-C

In a recent study under consideration at Nature Portfolio Journal and posted to the Research Square* preprint server, researchers demonstrated the evolution of multi-system inflammatory syndrome in children (MIS-C) following acute severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

12 Apr 2022