Molecular & Structural Biology

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Study provides new understanding of the earliest molecular events in Type 1 Diabetes pathogenesis

For the first time, researchers have revealed that during the development of Type 1 Diabetes (T1D), when insulin-producing cells in the pancreas are under attack from T lymphocytes, the cells lining the pancreatic duct reprogram themselves in an attempt to suppress autoimmune T cell responses.

28 Feb 2022

Novel mechanism that connects circadian rhythm and muscle repair discovered

Northwestern Medicine investigators have discovered a novel mechanism that connects circadian rhythm-controlled cellular metabolism and regeneration with muscle repair after injury, according to recent findings published in the journal Genes and Development.

28 Feb 2022

Spectacular structure of C.difficile's protective armor revealed

The spectacular structure of the protective armor of superbug C.difficile has been revealed for the first time showing the close-knit yet flexible outer layer – like chain mail.

25 Feb 2022

Researchers untangle the mysteries around type-2 diabetes

For more than 30 years, scientists have been trying to unravel the mystery of how a key biological molecule self assembles into a rogue protein-like substance known as amyloid, which is thought to play a role in the development of type-2 diabetes - a disease that affects 300 million people worldwide.

25 Feb 2022

Study shows how certain RNA molecules control the repair of damaged DNA in cancer cells

A new study from Karolinska Institutet in Sweden shows how certain RNA molecules control the repair of damaged DNA in cancer cells, a discovery that could eventually give rise to better cancer treatments. The study is published today in the journal Nature Communications.

23 Feb 2022

Subset of human auditory neurons responds to song

A new study indicates that not only does the human auditory cortex respond selectively to music compared to speech, but it is mediated by neuronal subpopulations that respond specifically to different types of music, including a subset for song.

23 Feb 2022

Accelerating genomics research with the firefly

In this interview, we speak to Paul Lomax from SPT Labtech about their new firefly platform and how it will help to accelerate genomics research.

From SPT Labtech 23 Feb 2022

CD91 receptor promotes SARS-CoV-2 infection

researchers find that LRP1/CD91 is a leading molecule in virus-host cell interactions that causes infection by many RNA viruses.

22 Feb 2022

New radio-labeled molecule may allow a non-invasive approach to monitor inflammation in real time

Researchers at The University of Texas MD Anderson Cancer Center have developed a new radio-labeled molecule capable of selectively reacting with certain high-energy radicals that are characteristic of innate immune activity, which may allow a non-invasive approach to monitor inflammation in real time by positron emission tomography (PET) imaging.

21 Feb 2022

Scientists use entire human GI tracts to shed light on cellular functions

If you get nervous, you might feel it in your gut. If you eat chili, your gut might revolt, but your friend can eat anything and feel great. You can pop ibuprofen like candy with no ill effects, but your friend's belly might bleed and she might get no pain relief.

21 Feb 2022

Researchers unravel essential final steps in the production of mRNA

Proteins need to interact in a complex manner for a so-called "messenger RNA" (mRNA) to be created in human cells from a precursor molecule. mRNA provides a blueprint for proteins; the first vaccines against the coronavirus are also based on mRNAs.

21 Feb 2022

Gradual decline in pathogenicity and enhanced cytokine induction in SARS-CoV-2 variants

A new study focuses on understanding the factors associated with the ability of the Omicron variant to infect a wide range of age groups.

20 Feb 2022

Inhalable antibody fragments offer broad protection from SARS-CoV-2 variants

A new study describes a potential new approach to treating COVID-19 in the form of single-chain fragment variable (scFv) antibodies.

20 Feb 2022

Mechanism of fatty-acid coupled adaptive immunity in SARS-CoV-2 revealed

A new study explains how SARS-CoV-2 adapts its immunogenicity to the immune response of the host.

20 Feb 2022

The impact of SARS-CoV-2 on lipids

SARS-CoV-2 appears to alter host lipid biosynthesis by relying on certain human metabolic pathways to survive and multiply effectively.

20 Feb 2022

Structure of protein that can pump toxic molecules out of bacterial cells revealed

MIT chemists have discovered the structure of a protein that can pump toxic molecules out of bacterial cells. Proteins similar to this one, which is found in E. coli, are believed to help bacteria become resistant to multiple antibiotics.

18 Feb 2022

Study reveals the structural, functional landscape of neutralizing antibodies against SARS-CoV-2 spike protein

The SARS-CoV-2 virus is continuously evolving and structural changes to the virus may impact the efficacy of antibody therapies and vaccines.

18 Feb 2022

Study hints a potential difference in molecular clockworks between the master and slave clock neurons

From tiny fruit flies to human beings, all animals on Earth maintain their daily rhythms based on their internal circadian clock.

17 Feb 2022

Certain flavonoids inhibit an enzyme involved in the formation of key hormone in yellow fever mosquito

When most people think of flavonoids, natural compounds found in plants and other organisms, their nutritional benefits probably come to mind first.

17 Feb 2022

Research shows alterations in transfer RNAs at the epigenetic level in cancer

A recently published paper in the journal Molecular Cancer by the group of Dr. Manel Esteller, Director of the Josep Carreras Leukaemia Research Institute, ICREA Research Professor and Genetics Chairman at the University of Barcelona, shows that transfer RNAs for certain amino acids are altered at the epigenetic level in some types of cancer, expressing it in an exaggerated manner in some cases and being deficient in others.

17 Feb 2022

Molecular & Structural Biology

Study provides new understanding of the earliest molecular events in Type 1 Diabetes pathogenesis

Novel mechanism that connects circadian rhythm and muscle repair discovered

Spectacular structure of C.difficile's protective armor revealed

Researchers untangle the mysteries around type-2 diabetes

Study shows how certain RNA molecules control the repair of damaged DNA in cancer cells

Subset of human auditory neurons responds to song

Accelerating genomics research with the firefly

CD91 receptor promotes SARS-CoV-2 infection

New radio-labeled molecule may allow a non-invasive approach to monitor inflammation in real time

Scientists use entire human GI tracts to shed light on cellular functions

Researchers unravel essential final steps in the production of mRNA

Gradual decline in pathogenicity and enhanced cytokine induction in SARS-CoV-2 variants

Inhalable antibody fragments offer broad protection from SARS-CoV-2 variants

Mechanism of fatty-acid coupled adaptive immunity in SARS-CoV-2 revealed

The impact of SARS-CoV-2 on lipids

Structure of protein that can pump toxic molecules out of bacterial cells revealed

Study reveals the structural, functional landscape of neutralizing antibodies against SARS-CoV-2 spike protein

Study hints a potential difference in molecular clockworks between the master and slave clock neurons

Certain flavonoids inhibit an enzyme involved in the formation of key hormone in yellow fever mosquito

Research shows alterations in transfer RNAs at the epigenetic level in cancer

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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