Molecular & Structural Biology

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Scientists reveal how 911 DNA checkpoint clamp helps repair the damaged DNA

When something goes wrong during DNA replication, cells call their own version of 911 to pause the process and fix the problem -; a failsafe that is critical to maintaining health and staving off disease.

22 Mar 2022

Researchers offer a clear picture of how the 9-1-1 clamp is recruited to sites of DNA damage

DNA is often likened to a blueprint. The particular sequence of As, Cs, Gs, and Ts in DNA provides information for building an organism.

21 Mar 2022

A complete transcriptomic analysis of astrocytes in Alzheimer's disease

An international group of researchers led by the UAB analyzed the genes that are expressed in neurons and astrocytes based on data from 800 individuals and compared what happens in Alzheimer's patients and in people without diagnosed dementia.

18 Mar 2022

New virus-based approach for measuring variations in gene regulatory elements

Tohoku University scientists in Japan have developed a virus-based approach for measuring variations in gene regulatory elements, called transcription factors, as conditions change in live organisms.

18 Mar 2022

Why does the SARS-CoV-2 Omicron variant escape immunity?

Researchers reveal the underlying mechanism associated with the Omicron variant’s increased transmissibility and ability to evade immunity.

17 Mar 2022

Immuno-metabolomic signatures that correlate with antigen-specific-T cell response during active COVID-19

Researchers investigate innate and adaptive immune responses at both the early and late stages of SARS-CoV-2 infection.

17 Mar 2022

Researchers find turbocharger for memory in the brain cells of mice

Scientists have long known that learning requires the flow of calcium into and out of brain cells. But researchers at Columbia's Zuckerman Institute have now discovered that floods of calcium originating from within neurons can also boost learning.

17 Mar 2022

RNA-chopping enzyme Dicer stabilizes mammalian chromosomes with the help of BRD4 activator

Cells use RNA as a versatile tool to regulate the activity of their genes. Small snippets of RNA can fine-tune how much protein is produced from various genes; some small RNAs can shut genes off altogether.

17 Mar 2022

Inhalable ‘aerogel’ induces immune response against COVID-19 in the lungs of mice

An inhalable 'aerogel' loaded with DNA that encodes for the SARS-CoV-2 spike protein successfully induces an immune response against COVID-19 in the lungs of mice, according to new research conducted at Penn State.

16 Mar 2022

Yale researchers uncover how to control the blood-brain barrier with a molecule

The brain is composed of billions of neurons-; vulnerable cells that require a protective environment to function properly.

16 Mar 2022

Study reveals how to identify and avoid risks related to mitochondrial therapeutic interventions

Research carried out at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) has demonstrated that mixing mitochondrial DNAs (mtDNAs) of different origins can have damaging effects over the medium and long term.

16 Mar 2022

Detailed molecular map of stratum corneum can help develop new skin treatments

Scientists have accurately analyzed the tough barrier layer of the skin giving the most detailed molecular map of its structure that will help in the development of new skin products and treatments.

14 Mar 2022

Using mRNA to introduce gene editor into human muscle stem cells

Mutations that lead to muscle atrophy can be repaired with the gene editor CRISPR-Cas9. A team led by ECRC researcher Helena Escobar has now introduced the tool into human muscle stem cells for the first time using mRNA, thus discovering a method suitable for therapeutic applications.

14 Mar 2022

Researchers find unusual way of stabilizing cancer-suppressing protein

The p53 protein protects our cells from cancer and is an interesting target for cancer treatments. The problem is, however, that it breaks down rapidly in the cell. Researchers at Karolinska Institutet in Sweden have now found an unusual way of stabilizing the protein and making it more potent.

14 Mar 2022

Scientists map key molecular changes during mouse embryogenesis

Scientists have mapped out the key molecular changes that orchestrate how embryonic mouse cells differentiate into the diverse cell types that will ultimately form all the different tissues and organs of the adult animal.

14 Mar 2022

Conformational variation of the SARS-CoV-2 energy landscape

Researchers demonstrate that the energy landscape of SARS-CoV-2 exhibits significant conformational variation.

14 Mar 2022

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Researchers demonstrate enhanced loss-of-function editing of CRISPR/Cas9 in human cells.

14 Mar 2022

Role of carboxypeptidase U in severe COVID-19

A new study measured both proCPU and CPU+CPUi over time to determine the impact of SARS-CoV-2 infection on the CPU system.

14 Mar 2022

Study may provide insight into the evolution of D-amino acid function in marine invertebrates

Amino acids are the basic building blocks of living organisms and typically occur in a configuration known as the L-form. However, there are a few exceptional examples of the structural mirror image of the L-form (known as the D-form) being present in animals.

11 Mar 2022

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Researchers led by Christopher Garcia of the Ludwig Center at Stanford University have solved the long-sought structure of a large signaling protein involved in responses to infection, inflammation, the generation of immune cells and when dysregulated by mutation-; the emergence of blood cancers known as myeloproliferative neoplasms.

11 Mar 2022

Molecular & Structural Biology

Scientists reveal how 911 DNA checkpoint clamp helps repair the damaged DNA

Researchers offer a clear picture of how the 9-1-1 clamp is recruited to sites of DNA damage

A complete transcriptomic analysis of astrocytes in Alzheimer's disease

New virus-based approach for measuring variations in gene regulatory elements

Why does the SARS-CoV-2 Omicron variant escape immunity?

Immuno-metabolomic signatures that correlate with antigen-specific-T cell response during active COVID-19

Researchers find turbocharger for memory in the brain cells of mice

RNA-chopping enzyme Dicer stabilizes mammalian chromosomes with the help of BRD4 activator

Inhalable ‘aerogel’ induces immune response against COVID-19 in the lungs of mice

Yale researchers uncover how to control the blood-brain barrier with a molecule

Study reveals how to identify and avoid risks related to mitochondrial therapeutic interventions

Detailed molecular map of stratum corneum can help develop new skin treatments

Using mRNA to introduce gene editor into human muscle stem cells

Researchers find unusual way of stabilizing cancer-suppressing protein

Scientists map key molecular changes during mouse embryogenesis

Conformational variation of the SARS-CoV-2 energy landscape

Bioactive small molecules enhance CRISPR/Cas9 loss-of-function editing in human cells

Role of carboxypeptidase U in severe COVID-19

Study may provide insight into the evolution of D-amino acid function in marine invertebrates

Researchers solve the structure of large signaling protein involved in emergence of blood cancers

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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