Molecular & Structural Biology

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Powerhouse-pruning protein may also help make energy rapidly available for growing new blood vessels

A protein that helps keep our cell powerhouses working at a premium appears to also help make energy rapidly available when it's time to make new blood vessels.

4 Apr 2022

Proteins in saliva strongly associated with the diagnosis of severe COVID-19

Researchers have identified a family of proteins that is significantly elevated in the saliva of patients hospitalized with COVID-19.

4 Apr 2022

Key protein could be a novel target for treatment of patients with B cell signaling deficiencies

The rules to the kids' game "red light, green light" are easy to follow: red always means stop, and green always means go. But now, researchers from Japan have found that a key protein involved in B cell signaling acts as both a red light to signaling in healthy cells and a green light to signaling in immune-deficient cells.

4 Apr 2022

Researchers use breast milk to identify new set of protein biomarkers for cancer

A simple blood test for women of all ages and risk levels could one day be possible thanks to a new set of protein biomarkers that researchers identified using breast milk.

4 Apr 2022

The mucosal antibody response to SARS-CoV-2

Researchers determine mucosal SARS-CoV-2-specific antibody levels and their neutralizing effect in pediatric and adult patients.

31 Mar 2022

The evolution of the SARS-CoV-2 spike protein

Researchers discuss the evolution and mechanisms of mutations that have occurred in the spike protein of SARS-CoV-2.

31 Mar 2022

Virginia Tech researcher awarded $1.9 million grant to study about mitophagy

Most of us remember enough biology to recall that mitochondria are known as "the powerhouse of the cell." Even that audacious term may downplay the importance of mitochondria and what happens when mitochondria go bad.

31 Mar 2022

Study sheds light on the conformational dynamics of SARS-CoV-1 and SARS-CoV-2 spike proteins

New computational simulations of the behavior of SARS-CoV-1 and SARS-CoV-2 spike proteins prior to fusion with human cell receptors show that SARS-CoV-2, the virus that causes COVID-19, is more stable and slower changing than the earlier version that caused the SARS epidemic in 2003.

31 Mar 2022

Role of SARS-CoV-2 S1 subunit in severe COVID-19

A new study aimed to determine whether portions of the SARS-CoV-2 spike protein are capable of activating innate immune cells like Gal-3.

30 Mar 2022

Researchers discover a four-protein complex that may play key role in generating ribosomes

UT Southwestern researchers have identified a four-protein complex that appears to play a key role in generating ribosomes – organelles that serve as protein factories for cells – as well as a surprising part in neurodevelopmental disorders.

29 Mar 2022

Strand displacement mechanism in RNA appears to switch genetic expression from “on” to “off”

Similar to a light switch, RNA switches (called riboswitches) determine which genes turn "on" and "off." Although this may seem like a simple process, the inner workings of these switches have confounded biologists for decades.

29 Mar 2022

New method for generating binding proteins solves a long-standing challenge in drug development

A team of scientists has created a powerful new method for generating protein drugs. Using computers, they designed molecules that can target important proteins in the body, such as the insulin receptor, as well as vulnerable proteins on the surface of viruses.

25 Mar 2022

Rutgers researchers use roundworms to unravel how cells communicate with one another

Scientists have long puzzled about a critical way that cells communicate with one another, but Rutgers researchers have used a simple roundworm to solve the mystery.

25 Mar 2022

New model reveals how antibodies navigate pathogen surfaces like a child at play

A new study shows how antibodies select the antigens that they bind to, as they navigate the surface of pathogens like coronaviruses.

24 Mar 2022

Study confirms no preexisting B-cell immunity against SARS-CoV-2 in pre-pandemic samples

A recent study finds that there is no considerable B-cell immunity against SARS-CoV-2 in unexposed healthy individuals.

23 Mar 2022

UI neuroscientists identify fundamental biochemical mechanism underlying memory storage

A University of Iowa neuroscience research team has identified a fundamental biochemical mechanism underlying memory storage and has linked this mechanism to cognitive deficits in mouse models of Alzheimer's Disease and Related Dementias.

23 Mar 2022

Investigators create specialized, tissue-like structures to model barrier tissues

Investigators at the Brigham and the Broad Institute have created specialized, tissue-like structures in the laboratory to model barrier tissues, such as the intestines, to identify new targets for treatment. Barrier tissues are exposed to substances from the outside world but serve as a layer of protection.

23 Mar 2022

Molecular & Structural Biology

Powerhouse-pruning protein may also help make energy rapidly available for growing new blood vessels

Proteins in saliva strongly associated with the diagnosis of severe COVID-19

Key protein could be a novel target for treatment of patients with B cell signaling deficiencies

Researchers use breast milk to identify new set of protein biomarkers for cancer

The mucosal antibody response to SARS-CoV-2

The evolution of the SARS-CoV-2 spike protein

Virginia Tech researcher awarded $1.9 million grant to study about mitophagy

Study sheds light on the conformational dynamics of SARS-CoV-1 and SARS-CoV-2 spike proteins

Role of SARS-CoV-2 S1 subunit in severe COVID-19

Researchers discover a four-protein complex that may play key role in generating ribosomes

Strand displacement mechanism in RNA appears to switch genetic expression from “on” to “off”

New method for generating binding proteins solves a long-standing challenge in drug development

Rutgers researchers use roundworms to unravel how cells communicate with one another

New model reveals how antibodies navigate pathogen surfaces like a child at play

Study confirms no preexisting B-cell immunity against SARS-CoV-2 in pre-pandemic samples

UI neuroscientists identify fundamental biochemical mechanism underlying memory storage

Investigators create specialized, tissue-like structures to model barrier tissues

Study reveals differences in SARS-CoV-2 and SARS-CoV-1 spike protein conformational changes

Accumulation of damaged mitochondria triggers inflammatory processes that cause muscle atrophy

Function of glycolytic enzyme depends on its cellular localization

Small solutions for big problems in drug discovery and delivery

Professor Nancy Ip: Pioneering New Paths in Neurodegenerative Therapy

Utilizing process Raman in optimizing cultivated meat production

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