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Study suggests concomitant antidepressant and statin use could prevent treatment discontinuation

A recent study in the journal BMC Medicine evaluates the real-world impact of combining antidepressants with statins in UK adults, revealing lower discontinuation rates but similar efficacy compared to antidepressant-only treatment.

12 Nov 2023

Developing a synthetic pathology framework: A step towards replacing animal testing

Researchers establish AnimalGAN as a reliable alternative for generating synthetic pathology data.

10 Nov 2023

Mucosal vaccine shows lasting defense against SARS-CoV-2 Omicron in primate study

In this groundbreaking study, researchers developed a mucosal adenoviral-vector vaccine, ChAd-SARS-CoV-2-S, which demonstrated sustained and robust immunity against a challenging Omicron variant in nonhuman primates, indicating a promising direction for durable COVID-19 protection strategies. Unlike traditional intramuscular vaccines, this mucosal vaccine elicited a comprehensive immune response, potentially paving the way for more effective and long-lasting COVID-19 vaccines.

9 Nov 2023

Bio Farma's Bio-TCV typhoid conjugate vaccine licensed in Indonesia following marketing approval

The International Vaccine Institute (IVI), an international organization with a mission to discover, develop, and deliver safe, effective, and affordable vaccines for global health, and Bio Farma, a biotechnology company based in West Java, Indonesia, announced today that Bio Farma's Bio-TCV typhoid conjugate vaccine (TCV) was licensed in Indonesia following marketing approval from Badan Pengawas Obat dan Makanan (BPOM), the national regulatory authority.

9 Nov 2023

How do sex hormones and birth control affect brain fear circuits?

Researchers explores how oral contraceptive pill use interacts with the current hormonal status to affect the fear circuit structure within the brain.

9 Nov 2023

New prodrug approach enhances drug delivery to brain cells

A new study from the University of Eastern Finland shows that the delivery of drugs into the brain, and especially into glial cells, can be enhanced with prodrugs that temporarily incorporate thyroxine or a thyroxine-like molecule.

8 Nov 2023

US to cover HIV prevention drugs for older Americans to stem spread of the virus

A proposed federal policy aims to protect older Americans from contracting HIV by offering free preventive medication, the latest effort to catch up to much of Europe and Africa in stemming the spread of the virus.

8 Nov 2023

Pharmacogenomics holds promise for personalized dementia therapies

Pharmacogenomics-based studies in the research for personalized therapeutics for dementia

8 Nov 2023

Immune imprinting: The crux of waning COVID-19 booster effectiveness against new variants

The study in Nature Microbiology reviews the concept of immune imprinting and its influence on antibody responses to SARS-CoV-2, highlighting challenges for COVID-19 booster vaccination efficacy against emerging variants. Researchers suggest that understanding immune imprinting is crucial for developing vaccines that elicit broad and lasting immune protection.

7 Nov 2023

Using TNF inhibitors during pregnancy not associated with worse fetal or obstetric outcomes

According to new research at ACR Convergence 2023, the American College of Rheumatology's (ACR) annual meeting, continuing tumor necrosis factor inhibitors during pregnancy is not associated with worse fetal or obstetric outcomes and may reduce the risk of severe maternal infections during pregnancy (Abstract #0477).

7 Nov 2023

MD Anderson and Jazz Pharmaceuticals collaborate to investigate the potential of zanidatamab in HER2-expressing cancers

The University of Texas MD Anderson Cancer Center and Jazz Pharmaceuticals plc today announced a five-year strategic research collaboration agreement to evaluate zanidatamab, Jazz's investigational HER2-targeted bispecific antibody, in multiple HER2-expressing cancers.

7 Nov 2023

Omicron variant BA.2.86 spreads faster, but current antivirals hold the line

Researchers discover the BA.2.86 Omicron lineage with higher transmission potential than current dominant strains, yet show that existing antivirals remain effective. Despite its higher infectivity, BA.2.86 exhibits lower pathogenicity in hamsters, indicating decreased replication capacity may lead to less severe infections.

7 Nov 2023

Study sheds light on seasonal trends in adolescent depression and antidepressant prescribing

Researchers determined seasonal patterns in primary care antidepressant prescribing and consultations for mental health issues in adolescents and young adults living in England, United Kingdom (UK).

6 Nov 2023

SSRIs show promise in easing post-COVID struggles, Dutch study reveals

Dutch study finds SSRIs significantly alleviate post-COVID syndrome symptoms, offering promising treatment avenues and shedding light on neurobiological mechanisms at play.

5 Nov 2023

Synthetic melanin nanoparticles boost wound healing and tissue repair in skin

In a recent study published in npj Regenerative Medicine, researchers discuss the ability of melanin nanoparticles to support wound recovery in mice. The effects at histological and gene levels were explored and confirmed on biomimetic models and human skin explants.

5 Nov 2023

Dental opioid prescribing declines in the U.S., but pandemic slows progressNovember 3, 2023

Americans who have a tooth pulled or another painful dental procedure in the United States today are far less likely to get opioid painkillers than they were just a few years ago, a University of Michigan study shows.

3 Nov 2023

Study highlights safety concerns of SGLT2i in patients with diabetes and cancer

Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have heart- and kidney-related benefits for patients with and without diabetes that go beyond their initial indication for lowering blood sugar levels.

2 Nov 2023

New mechanism discovered for aspirin's cancer-fighting properties

LMU researchers have identified a signaling pathway by which aspirin can inhibit colorectal cancer.

2 Nov 2023

New treatment breakthrough: Pyrotinib combo demonstrates remarkable efficacy for HER2 positive metastatic breast cancer

The safety and efficacy of treating human epidermal growth factor receptor 2 (HER2)-positive metastatic breast cancer with pyrotinib.

2 Nov 2023

Seaweed symbionts reveal treasure trove of potential drug compounds

Marine macroalgae-associated Bacillota reveal a trove of bioactive compounds with potential pharmacological benefits, from antibacterial to anticancer properties. This comprehensive review illuminates the promising yet underexplored therapeutic applications of these marine microorganisms.

1 Nov 2023

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Pharmaceutical News

Study suggests concomitant antidepressant and statin use could prevent treatment discontinuation

Developing a synthetic pathology framework: A step towards replacing animal testing

Mucosal vaccine shows lasting defense against SARS-CoV-2 Omicron in primate study

Bio Farma's Bio-TCV typhoid conjugate vaccine licensed in Indonesia following marketing approval

How do sex hormones and birth control affect brain fear circuits?

New prodrug approach enhances drug delivery to brain cells

US to cover HIV prevention drugs for older Americans to stem spread of the virus

Pharmacogenomics holds promise for personalized dementia therapies

Immune imprinting: The crux of waning COVID-19 booster effectiveness against new variants

Using TNF inhibitors during pregnancy not associated with worse fetal or obstetric outcomes

MD Anderson and Jazz Pharmaceuticals collaborate to investigate the potential of zanidatamab in HER2-expressing cancers

Omicron variant BA.2.86 spreads faster, but current antivirals hold the line

Study sheds light on seasonal trends in adolescent depression and antidepressant prescribing

SSRIs show promise in easing post-COVID struggles, Dutch study reveals

Synthetic melanin nanoparticles boost wound healing and tissue repair in skin

Dental opioid prescribing declines in the U.S., but pandemic slows progressNovember 3, 2023

Study highlights safety concerns of SGLT2i in patients with diabetes and cancer

New mechanism discovered for aspirin's cancer-fighting properties

New treatment breakthrough: Pyrotinib combo demonstrates remarkable efficacy for HER2 positive metastatic breast cancer

Seaweed symbionts reveal treasure trove of potential drug compounds

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