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Viral rebound common in lung transplant recipients treated with nirmatrelvir/ritonavir for COVID-19

Data on the viral rebound and safety of nirmatrelvir/ritonavir in lung transplant (LTx) recipients are limited.

24 Oct 2023

Study identifies predictors of opioid overdose after prescription for chronic pain

A large study published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.230459 identified 10 predictors of opioid overdose after prescription for chronic pain, which can help clinicians engage in shared decision-making with patients around opioid prescribing.

24 Oct 2023

University of Montana awarded $12.3 million contract to develop novel vaccine adjuvant for TB vaccine

The National Institutes of Health recently awarded a $12.3 million contract to the University of Montana to develop a novel vaccine adjuvant for use in a tuberculosis vaccine. Adjuvants are substances that boost the effectiveness of vaccines.

24 Oct 2023

Groundbreaking study reveals most effective adjunctive drug for Parkinson's disease

The efficacy, tolerability, and safety of various anti-Parkinson's drugs.

23 Oct 2023

Ketamine's long-lasting antidepressant effects unveiled in new study

Persistent blocking of NMDAR and burst-type firing by lateral habenula (LHb) neurons may offer a basis for the long-lasting antidepressant effects of ketamine.

22 Oct 2023

Novel GLP-1 receptor agonists offer hope for long-lasting diabetes treatment

In a study published in Scientific Reports, researchers engineer long-lasting GLP-1 receptor agonists by fusing GLP-1 with an HSA-binding protein. These chimeric molecules show promise for the treatment of type 2 diabetes due to their stability, functionality, and high affinity for the GLP-1 receptor and human serum albumin.

22 Oct 2023

How ketamine treatment elicits long-lasting anti-depressive effects

Researchers discuss the mechanisms responsible for the sustained antidepressant effects of ketamine by examining ketamine-NMDAR interactions.

20 Oct 2023

Steroid use linked to increased concussion risk in high school athletes

Higher body mass index and increased aggression caused by steroid use could increase the potential for sustaining a concussion, researchers say.

19 Oct 2023

Biden pick to lead NIH finally has her day, but still gets caught up in drug price debate

A Senate committee finally held a hearing Wednesday on President Joe Biden's pick to lead the National Institutes of Health. But the panel's chair, Sen. Bernie Sanders (I-Vt.), was focused on drug prices — an issue over which the NIH has very little control.

19 Oct 2023

Study finds strong link between genetic predisposition for blood clots and contraceptive pill use

Women with a high genetic predisposition for blood clots are six times more likely to develop a blood clot during the first two years of using contraceptive pills according to a new study from Uppsala University.

19 Oct 2023

Assessing COVID-19 vaccine effectiveness against long COVID

Researchers discuss SARS-CoV-2 vaccine effectiveness in preventing long COVID in fully vaccinated individuals.

19 Oct 2023

Study compares two widely used statins for treating patients with coronary artery disease

Two widely used statins, rosuvastatin and atorvastatin, are equally effective at preventing heart attacks, strokes and death in people with coronary artery disease.

18 Oct 2023

Deep learning algorithm identifies antimalarial drug as promising treatment for osteoporosis

Artificial intelligence has exploded in popularity and is being harnessed by some scientists to predict which molecules could treat illnesses, or to quickly screen existing medicines for new applications.

18 Oct 2023

Precision oncology therapies account for nearly half of new cancer drug approvals since 1998

Of the 198 new oncology drugs approved by the U.S. Food and Drug Administration (FDA) between 1998 and 2022, approximately 43% were precision oncology therapies, the use of which is guided by biomarker testing.

18 Oct 2023

More antibiotics not better for preventing infection after joint replacement surgery, study finds

Knee and hip replacements are increasing globally due to an aging population. In the United States, the number of patients needing a joint replacement will exceed 2.7 million in the next 7 years.

18 Oct 2023

Oral diabetes and obesity meds danuglipron and orforglipron show promise but have gastrointestinal drawbacks

New orally-administered GLP-1 receptor agonists danuglipron and orforglipron show promise in treating type 2 diabetes and obesity, according to a systematic review. While effective in glycemic control and weight reduction, these drugs come with gastrointestinal side effects that may lead to treatment discontinuation.

17 Oct 2023

Skyrocketing demand for weight-loss drugs prompts calls for informed prescribing

The study reveals a significant increase in the usage of GLP-1 receptor agonists, particularly Ozempic and Trulicity, for weight management and Type 2 diabetes in the U.S. from 2014 to 2022. Amidst rapid growth and shortages, the paper calls for evidence-based decision-making to ensure stable medication supply and effective treatment.

17 Oct 2023

Tirzepatide boosts weight loss in lifestyle intervention patients, but comes with a catch

In a groundbreaking 84-week-long study, researchers found that tirzepatide, a medication initially designed for treating type 2 diabetes, significantly bolstered weight loss in overweight and obese patients already on intensive lifestyle programs. While the drug showed promise in further reducing body weight and improving cardiometabolic factors, mild to moderate gastrointestinal side effects were the most common drawback.

16 Oct 2023

Save the environment and protect your skin while doing it – the 'cherry on top'

Researchers discover a sustainable way to repurpose tart cherry waste, harnessing its bioactive compounds for skin care applications. The study reveals that these extracts significantly protect human skin cells from oxidative stress, offering an eco-friendly solution to both food waste and skin health.

16 Oct 2023

Moffitt Cancer Center researchers identify hidden target of ROS1 inhibitor lorlatinib

Targeted cancer drugs are widely used because of their ability to inhibit specific proteins involved in cancer development with fewer side effects compared to chemotherapy drugs.

16 Oct 2023

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Pharmaceutical News

Viral rebound common in lung transplant recipients treated with nirmatrelvir/ritonavir for COVID-19

Study identifies predictors of opioid overdose after prescription for chronic pain

University of Montana awarded $12.3 million contract to develop novel vaccine adjuvant for TB vaccine

Groundbreaking study reveals most effective adjunctive drug for Parkinson's disease

Ketamine's long-lasting antidepressant effects unveiled in new study

Novel GLP-1 receptor agonists offer hope for long-lasting diabetes treatment

How ketamine treatment elicits long-lasting anti-depressive effects

Steroid use linked to increased concussion risk in high school athletes

Biden pick to lead NIH finally has her day, but still gets caught up in drug price debate

Study finds strong link between genetic predisposition for blood clots and contraceptive pill use

Assessing COVID-19 vaccine effectiveness against long COVID

Study compares two widely used statins for treating patients with coronary artery disease

Deep learning algorithm identifies antimalarial drug as promising treatment for osteoporosis

Precision oncology therapies account for nearly half of new cancer drug approvals since 1998

More antibiotics not better for preventing infection after joint replacement surgery, study finds

Oral diabetes and obesity meds danuglipron and orforglipron show promise but have gastrointestinal drawbacks

Skyrocketing demand for weight-loss drugs prompts calls for informed prescribing

Tirzepatide boosts weight loss in lifestyle intervention patients, but comes with a catch

Save the environment and protect your skin while doing it – the 'cherry on top'

Moffitt Cancer Center researchers identify hidden target of ROS1 inhibitor lorlatinib

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