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New fund could incentivize development of high-priced drugs with weak clinical evidence

A new fund to fast-track patient access to potentially valuable new medicines may incentivize the pharmaceutical industry to develop high-priced drugs for rare diseases with weak evidence on clinical benefits.

7 Sep 2023

Study uncovers thousands of medication pairings linked to frequent dosage adjustments

Researchers investigated the complexity of polypharmacy and whether frequent dose adjustments were required for co-medications and drug pairs in hospital settings.

7 Sep 2023

Antipsychotics are likely overprescribed among homebound patients with dementia, study shows

New research published in the Journal of the American Geriatrics Society indicates that antipsychotics are likely overprescribed and used inappropriately among patients with Alzheimer's disease and related dementias (ADRD) receiving home health care, and such use is linked to worse patient outcomes.

7 Sep 2023

Broad-spectrum antibiotics linked to higher sepsis risk in neonates

A preprint presents evidence for the hypothesis that neonatal sepsis is linked to prenatal antibiotics.

7 Sep 2023

Experimental insomnia treatment may help prevent opioid relapse

A good night's sleep has many proven health benefits, and a new Scripps Research study suggests one more: preventing opioid relapse.

6 Sep 2023

Researchers characterize new SARS-CoV-2 BA.2.86 variant neutralization by monoclonal antibodies

Researchers used a SARS-CoV-2 spike protein-pseudotyped viral model to characterize BA.2.86 variant neutralization by monoclonal antibodies.

6 Sep 2023

Clovibactin - a game-changing novel antibiotic with no resistance

Researchers reported the discovery of a new antibiotic, clovibactin.

6 Sep 2023

Monovalent vaccine outperforms bivalent in fighting new Omicron variants

New U.S. study finds mRNA-1273.815, a monovalent vaccine targeting the Omicron XBB.1.5 variant, generates higher neutralizing antibody titers compared to its bivalent counterpart. The study supports updating to an XBB.1.5-based monovalent vaccine for the 2023-24 campaign to combat emerging variants.

5 Sep 2023

Novavax's updated XBB.1.5 vaccine shows promising cross-neutralizing antibodies against new COVID-19 variants

The study reveals that Novavax's updated XBB.1.5 vaccine effectively induces cross-neutralizing antibodies against multiple Omicron XBB sub-variants in both mice and non-human primates.

5 Sep 2023

DOAC use associated with reduction in dementia risk compared to traditional blood thinners

The use of direct oral anticoagulants (DOACs) was associated with a reduction in dementia risk compared to traditional blood thinners - like warfarin - in atrial fibrillation patients, particularly in Asian patients.

5 Sep 2023

Experts call for changes to how drugs are tested and labeled for people with obesity

A new opinion piece published in Health Affairs Forefront raises questions around current approaches to assess drug safety and effectiveness in people with obesity.

5 Sep 2023

UK government invests £5.5 million in Medicines Manufacturing Skills Centre of Excellence

The government is helping to sustain and grow the 280,000-strong UK life sciences workforce by today (Tuesday 5 September) announcing £5.5 million to establish a Medicines Manufacturing Skills Centre of Excellence.

5 Sep 2023

What are the efficacy and safety of psilocybin in patients with major depressive disorder?

The safety, timing, magnitude, and durability of the antidepressant psilocybin on patients with major depressive disorders.

4 Sep 2023

Study highlights risks of high-dose naloxone in opioid overdose response

Whether regular distribution of two intranasal or intramuscular administrations of low-dose naloxone was effective and adequate in reversing opioid overdoses.

4 Sep 2023

ChatGPT can debunk vaccine myths and increase vaccine uptake, study finds

ChatGPT could help to increase vaccine uptake by debunking myths around jab safety, say the authors of a study published in the peer-reviewed journal Human Vaccines and Immunotherapeutics.

4 Sep 2023

Oral diabetes drug semaglutide fights obesity in mice: A game-changer for human treatment?

The study reveals that oral semaglutide, a medication primarily used for type 2 diabetes, effectively reduces body weight and blood glucose levels in diet-induced obese mice. The findings suggest that this drug could be a promising treatment for obesity and offer a suitable animal model for future research.

3 Sep 2023

Explosive Hazard Identification in Pharmaceutical Process Development

Scitegrity, a leading company in chemical regulatory compliance, is excited to announce the expanded release of its Dangerous Goods Assessor for Pharmaceutical Process Development and safety teams.

From Scitegrity 1 Sep 2023

Amgen to discuss application for LUMAKRAS® (sotorasib) for the treatment of KRAS G12C-positive NSCLC at FDA advisory committee meeting

Amgen today announced the U.S. Food and Drug Administration (FDA) Oncologic Drugs Advisory Committee (ODAC) will review data supporting the supplemental New Drug Application (sNDA) for the full approval of LUMAKRAS® (sotorasib) for adults with previously treated locally advanced or metastatic KRAS G12C-mutated non-small cell lung cancer (NSCLC) at a meeting on Oct. 5, 2023.

From AMGEN 1 Sep 2023

Low-dose aspirin linked to 15% lower risk of type 2 diabetes in older adults

New research to be presented at this year's Annual Meeting of the European Association for the Study of Diabetes (EASD) in Hamburg, Germany (2-6 October) shows that use of low dose (100mg daily) aspirin among older adults aged 65 years and older is associated with a 15% lower risk of developing type 2 diabetes.

31 Aug 2023

Boosters slow antibody waning but hit a ceiling: Long-term COVID study reveals limits of immunity

The study tracks the long-term kinetics of antibody responses to SARS-CoV-2 after vaccination and infections in New York healthcare workers from 2020 to 2023. It reveals that antibody waning is slower after booster shots, but there's an upper limit to antibody levels, which gradually lowers with repeated SARS-CoV-2 exposures and vaccinations.

31 Aug 2023

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Pharmaceutical News

New fund could incentivize development of high-priced drugs with weak clinical evidence

Study uncovers thousands of medication pairings linked to frequent dosage adjustments

Antipsychotics are likely overprescribed among homebound patients with dementia, study shows

Broad-spectrum antibiotics linked to higher sepsis risk in neonates

Experimental insomnia treatment may help prevent opioid relapse

Researchers characterize new SARS-CoV-2 BA.2.86 variant neutralization by monoclonal antibodies

Clovibactin - a game-changing novel antibiotic with no resistance

Monovalent vaccine outperforms bivalent in fighting new Omicron variants

Novavax's updated XBB.1.5 vaccine shows promising cross-neutralizing antibodies against new COVID-19 variants

DOAC use associated with reduction in dementia risk compared to traditional blood thinners

Experts call for changes to how drugs are tested and labeled for people with obesity

UK government invests £5.5 million in Medicines Manufacturing Skills Centre of Excellence

What are the efficacy and safety of psilocybin in patients with major depressive disorder?

Study highlights risks of high-dose naloxone in opioid overdose response

ChatGPT can debunk vaccine myths and increase vaccine uptake, study finds

Oral diabetes drug semaglutide fights obesity in mice: A game-changer for human treatment?

Explosive Hazard Identification in Pharmaceutical Process Development

Amgen to discuss application for LUMAKRAS® (sotorasib) for the treatment of KRAS G12C-positive NSCLC at FDA advisory committee meeting

Low-dose aspirin linked to 15% lower risk of type 2 diabetes in older adults

Boosters slow antibody waning but hit a ceiling: Long-term COVID study reveals limits of immunity

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